rs688011

Homo sapiens
G>A
LOC105369499 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0281 (8404/29910,GnomAD)
A=0268 (7825/29118,TOPMED)
A=0252 (1261/5008,1000G)
A=0298 (1148/3854,ALSPAC)
A=0301 (1116/3708,TWINSUK)
chr11:113283448 (GRCh38.p7) (11q23.2)
ND
GWASdb2
1   publication(s)
See rs on genome
243 Enhancers around
29 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.113283448G>A
GRCh37.p13 chr 11 fix patch HG306_PATCHNW_003871078.1:g.466174G>A
GRCh37.p13 chr 11NC_000011.9:g.113154170G>A

Gene: LOC105369499, uncharacterized LOC105369499(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105369499 transcript variant X1XR_001748388.1:n.N/AIntron Variant
LOC105369499 transcript variant X2XR_001748389.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.784A=0.216
1000GenomesAmericanSub694G=0.790A=0.210
1000GenomesEast AsianSub1008G=0.915A=0.085
1000GenomesEuropeSub1006G=0.683A=0.317
1000GenomesGlobalStudy-wide5008G=0.748A=0.252
1000GenomesSouth AsianSub978G=0.570A=0.430
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.702A=0.298
The Genome Aggregation DatabaseAfricanSub8706G=0.763A=0.237
The Genome Aggregation DatabaseAmericanSub838G=0.850A=0.150
The Genome Aggregation DatabaseEast AsianSub1614G=0.908A=0.092
The Genome Aggregation DatabaseEuropeSub18450G=0.675A=0.324
The Genome Aggregation DatabaseGlobalStudy-wide29910G=0.719A=0.281
The Genome Aggregation DatabaseOtherSub302G=0.720A=0.280
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.731A=0.268
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.699A=0.301
PMID Title Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.Wang KSDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs6880111.08E-05nicotine dependence (smoking)22377092

eQTL of rs688011 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr11:113154170TTC12ENSG00000149292.12G>A3.5021e-10-31081Cerebellum
Chr11:113154170TTC12ENSG00000149292.12G>A2.0791e-13-31081Cortex

meQTL of rs688011 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr11449140449294E067-16880
chr11451917451975E067-14199
chr11470287470555E0674113
chr11476036476111E0679862
chr11476189476245E06710015
chr11476501476590E06710327
chr11476777476837E06710603
chr11477085477135E06710911
chr11477159477329E06710985
chr11477457477585E06711283
chr11479158479332E06712984
chr11479455479574E06713281
chr11494512494631E06728338
chr11494697495232E06728523
chr11495269495499E06729095
chr11495547495630E06729373
chr11495663496075E06729489
chr11496162496265E06729988
chr11496298496347E06730124
chr11499603499701E06733429
chr11499719499778E06733545
chr11499830499904E06733656
chr11501848501898E06735674
chr11502035502126E06735861
chr11502174502387E06736000
chr11502430502826E06736256
chr11502859503105E06736685
chr11443545443981E068-22193
chr11451917451975E068-14199
chr11468203468961E0682029
chr11468994469034E0682820
chr11494370494468E06828196
chr11494512494631E06828338
chr11494697495232E06828523
chr11495269495499E06829095
chr11495547495630E06829373
chr11501478501825E06835304
chr11501848501898E06835674
chr11502035502126E06835861
chr11502174502387E06836000
chr11502430502826E06836256
chr11502859503105E06836685
chr11451917451975E069-14199
chr11452027452531E069-13643
chr11452536452752E069-13422
chr11476036476111E0699862
chr11476189476245E06910015
chr11476501476590E06910327
chr11476777476837E06910603
chr11477085477135E06910911
chr11477159477329E06910985
chr11477457477585E06911283
chr11477755477862E06911581
chr11479158479332E06912984
chr11479455479574E06913281
chr11493906494047E06927732
chr11494058494130E06927884
chr11494241494313E06928067
chr11494370494468E06928196
chr11494512494631E06928338
chr11494697495232E06928523
chr11495269495499E06929095
chr11495547495630E06929373
chr11495663496075E06929489
chr11496162496265E06929988
chr11496298496347E06930124
chr11498278498426E06932104
chr11498451498524E06932277
chr11498529498628E06932355
chr11498693499250E06932519
chr11499324499461E06933150
chr11499488499581E06933314
chr11499603499701E06933429
chr11499719499778E06933545
chr11499830499904E06933656
chr11500379500437E06934205
chr11501848501898E06935674
chr11502174502387E06936000
chr11502859503105E06936685
chr11449140449294E070-16880
chr11452027452531E070-13643
chr11452536452752E070-13422
chr11468203468961E0702029
chr11451917451975E071-14199
chr11452027452531E071-13643
chr11468203468961E0712029
chr11476501476590E07110327
chr11476777476837E07110603
chr11477085477135E07110911
chr11477159477329E07110985
chr11477457477585E07111283
chr11478958479092E07112784
chr11479158479332E07112984
chr11479455479574E07113281
chr11493906494047E07127732
chr11494058494130E07127884
chr11494241494313E07128067
chr11494370494468E07128196
chr11494512494631E07128338
chr11494697495232E07128523
chr11495269495499E07129095
chr11495547495630E07129373
chr11495663496075E07129489
chr11496162496265E07129988
chr11496298496347E07130124
chr11500023500103E07133849
chr11500150500204E07133976
chr11500300500354E07134126
chr11500379500437E07134205
chr11500499500850E07134325
chr11501049501247E07134875
chr11501292501441E07135118
chr11501478501825E07135304
chr11501848501898E07135674
chr11502035502126E07135861
chr11502174502387E07136000
chr11502859503105E07136685
chr11449140449294E072-16880
chr11451917451975E072-14199
chr11452027452531E072-13643
chr11452536452752E072-13422
chr11468203468961E0722029
chr11468994469034E0722820
chr11469139469267E0722965
chr11472227472287E0726053
chr11472344472499E0726170
chr11476189476245E07210015
chr11476501476590E07210327
chr11476777476837E07210603
chr11477085477135E07210911
chr11477159477329E07210985
chr11477457477585E07211283
chr11477755477862E07211581
chr11478958479092E07212784
chr11479158479332E07212984
chr11479455479574E07213281
chr11483789483839E07217615
chr11488166488295E07221992
chr11488364488445E07222190
chr11488497488547E07222323
chr11488609488670E07222435
chr11489126489403E07222952
chr11489467489517E07223293
chr11489720489770E07223546
chr11490602490804E07224428
chr11490808490965E07224634
chr11491061491286E07224887
chr11493906494047E07227732
chr11494058494130E07227884
chr11494241494313E07228067
chr11494370494468E07228196
chr11494512494631E07228338
chr11494697495232E07228523
chr11495269495499E07229095
chr11495547495630E07229373
chr11495663496075E07229489
chr11496162496265E07229988
chr11496298496347E07230124
chr11496501496598E07230327
chr11496751497301E07230577
chr11497354497462E07231180
chr11497599498241E07231425
chr11498278498426E07232104
chr11498451498524E07232277
chr11498529498628E07232355
chr11498693499250E07232519
chr11499324499461E07233150
chr11499488499581E07233314
chr11501049501247E07234875
chr11501292501441E07235118
chr11501478501825E07235304
chr11501848501898E07235674
chr11502035502126E07235861
chr11502174502387E07236000
chr11502430502826E07236256
chr11502859503105E07236685
chr11476777476837E07310603
chr11477085477135E07310911
chr11477159477329E07310985
chr11477457477585E07311283
chr11479158479332E07312984
chr11479455479574E07313281
chr11494370494468E07328196
chr11494512494631E07328338
chr11494697495232E07328523
chr11495269495499E07329095
chr11495547495630E07329373
chr11495663496075E07329489
chr11496162496265E07329988
chr11496298496347E07330124
chr11501478501825E07335304
chr11501848501898E07335674
chr11502035502126E07335861
chr11502174502387E07336000
chr11502430502826E07336256
chr11502859503105E07336685
chr11449140449294E074-16880
chr11451917451975E074-14199
chr11468203468961E0742029
chr11468994469034E0742820
chr11469139469267E0742965
chr11469367469461E0743193
chr11476501476590E07410327
chr11476777476837E07410603
chr11477085477135E07410911
chr11477159477329E07410985
chr11477457477585E07411283
chr11478958479092E07412784
chr11479158479332E07412984
chr11479455479574E07413281
chr11493906494047E07427732
chr11494058494130E07427884
chr11494241494313E07428067
chr11494370494468E07428196
chr11494512494631E07428338
chr11494697495232E07428523
chr11495269495499E07429095
chr11495547495630E07429373
chr11495663496075E07429489
chr11496162496265E07429988
chr11496298496347E07430124
chr11499603499701E07433429
chr11499719499778E07433545
chr11499830499904E07433656
chr11500023500103E07433849
chr11500150500204E07433976
chr11500300500354E07434126
chr11500379500437E07434205
chr11500499500850E07434325
chr11501049501247E07434875
chr11501292501441E07435118
chr11501478501825E07435304
chr11501848501898E07435674
chr11502035502126E07435861
chr11502174502387E07436000
chr11502430502826E07436256
chr11502859503105E07436685
chr11449140449294E081-16880
chr11451917451975E081-14199
chr11452027452531E081-13643
chr11451917451975E082-14199
chr11452027452531E082-13643
chr11452536452752E082-13422










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr11447922449037E067-17137
chr11449822451623E067-14551
chr11506103508291E06739929
chr11447922449037E068-17137
chr11449822451623E068-14551
chr11506103508291E06839929
chr11447922449037E069-17137
chr11449822451623E069-14551
chr11506103508291E06939929
chr11447922449037E070-17137
chr11449822451623E070-14551
chr11506103508291E07039929
chr11447922449037E071-17137
chr11449822451623E071-14551
chr11506103508291E07139929
chr11447922449037E072-17137
chr11449822451623E072-14551
chr11506103508291E07239929
chr11447922449037E073-17137
chr11449822451623E073-14551
chr11506103508291E07339929
chr11447922449037E074-17137
chr11449822451623E074-14551
chr11506103508291E07439929
chr11449822451623E081-14551
chr11506103508291E08139929
chr11447922449037E082-17137
chr11449822451623E082-14551
chr11506103508291E08239929