rs690371

Homo sapiens
G>A
FDXR : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0269 (32303/119896,ExAC)
G=0259 (7739/29872,GnomAD)
G=0257 (7498/29118,TOPMED)
A==0263 (3428/13006,GO-ESP)
G=0298 (1491/5008,1000G)
G=0264 (1017/3854,ALSPAC)
G=0247 (917/3708,TWINSUK)
chr17:74862956 (GRCh38.p7) (17q25.1)
AD
GWASdb2
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.74862956G>A
GRCh37.p13 chr 17NC_000017.10:g.72859078A>G

Gene: FDXR, ferredoxin reductase(minus strand)

Molecule type Change Amino acid[Codon] SO Term
FDXR transcript variant 3NM_001258012.3:c.N/AIntron Variant
FDXR transcript variant 4NM_001258013.3:c.N/AIntron Variant
FDXR transcript variant 5NM_001258014.3:c.N/AIntron Variant
FDXR transcript variant 6NM_001258015.2:c.N/AIntron Variant
FDXR transcript variant 7NM_001258016.3:c.N/AIntron Variant
FDXR transcript variant 2NM_004110.5:c.N/AIntron Variant
FDXR transcript variant 1NM_024417.4:c.N/AIntron Variant
FDXR transcript variant 8NR_047576.2:n.N/AIntron Variant
FDXR transcript variant X4XM_006721772.1:c.N/AIntron Variant
FDXR transcript variant X1XM_011524527.1:c.N/AIntron Variant
FDXR transcript variant X2XM_011524528.1:c.N/AIntron Variant
FDXR transcript variant X3XM_011524529.1:c.N/AIntron Variant
FDXR transcript variant X5XM_011524531.2:c.N/AIntron Variant
FDXR transcript variant X6XM_011524532.2:c.N/AIntron Variant
FDXR transcript variant X7XM_011524533.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.719G==0.281
1000GenomesAmericanSub694A=0.820G==0.180
1000GenomesEast AsianSub1008A=0.527G==0.473
1000GenomesEuropeSub1006A=0.734G==0.266
1000GenomesGlobalStudy-wide5008A=0.702G==0.298
1000GenomesSouth AsianSub978A=0.750G==0.250
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.736G==0.264
The Exome Aggregation ConsortiumAmericanSub21652A=0.791G==0.208
The Exome Aggregation ConsortiumAsianSub24986A=0.652G==0.347
The Exome Aggregation ConsortiumEuropeSub72364A=0.739G==0.260
The Exome Aggregation ConsortiumGlobalStudy-wide119896A=0.730G==0.269
The Exome Aggregation ConsortiumOtherSub894A=0.700G==0.300
The Genome Aggregation DatabaseAfricanSub8700A=0.737G==0.263
The Genome Aggregation DatabaseAmericanSub838A=0.820G==0.180
The Genome Aggregation DatabaseEast AsianSub1618A=0.481G==0.519
The Genome Aggregation DatabaseEuropeSub18414A=0.763G==0.236
The Genome Aggregation DatabaseGlobalStudy-wide29872A=0.740G==0.259
The Genome Aggregation DatabaseOtherSub302A=0.620G==0.380
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.742G==0.257
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.753G==0.247
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs6903710.00056alcohol dependence20201924

eQTL of rs690371 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr17:72859078FDXRENSG00000161513.7A>G1.8977e-7-10078Cortex

meQTL of rs690371 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr177280928272809459E067-49619
chr177280946572809552E067-49526
chr177280993772810085E067-48993
chr177281152572811636E067-47442
chr177281170072811980E067-47098
chr177281201572812109E067-46969
chr177281216972812442E067-46636
chr177281693372817003E067-42075
chr177281717772817263E067-41815
chr177281738372817433E067-41645
chr177281743472817488E067-41590
chr177281750172817572E067-41506
chr177281765472817726E067-41352
chr177281782872817878E067-41200
chr177281796572818100E067-40978
chr177281828572818355E067-40723
chr177281836372818437E067-40641
chr177281851472818747E067-40331
chr177281877772818834E067-40244
chr177281973572819794E067-39284
chr177281986072819920E067-39158
chr177282005372820103E067-38975
chr177282013472820174E067-38904
chr177282022672820451E067-38627
chr177282051772820826E067-38252
chr177282085272821007E067-38071
chr177282108272821287E067-37791
chr177282136772821452E067-37626
chr177282159272821642E067-37436
chr177282166772821861E067-37217
chr177282190572821965E067-37113
chr177282214172822416E067-36662
chr177283704572837739E067-21339
chr177283774072838106E067-20972
chr177283816472839396E067-19682
chr177285208672852196E067-6882
chr177285221872852383E067-6695
chr177286789372868134E0678815
chr177280928272809459E068-49619
chr177280946572809552E068-49526
chr177280993772810085E068-48993
chr177281693372817003E068-42075
chr177281717772817263E068-41815
chr177281738372817433E068-41645
chr177281743472817488E068-41590
chr177281750172817572E068-41506
chr177281765472817726E068-41352
chr177281782872817878E068-41200
chr177281796572818100E068-40978
chr177281828572818355E068-40723
chr177281836372818437E068-40641
chr177281851472818747E068-40331
chr177281877772818834E068-40244
chr177281884072819046E068-40032
chr177281907472819673E068-39405
chr177281973572819794E068-39284
chr177281986072819920E068-39158
chr177282005372820103E068-38975
chr177282013472820174E068-38904
chr177282022672820451E068-38627
chr177282051772820826E068-38252
chr177282085272821007E068-38071
chr177282108272821287E068-37791
chr177282136772821452E068-37626
chr177282159272821642E068-37436
chr177282166772821861E068-37217
chr177282190572821965E068-37113
chr177282214172822416E068-36662
chr177282259172822787E068-36291
chr177282315872823224E068-35854
chr177282335672823436E068-35642
chr177282832472828404E068-30674
chr177282865472828803E068-30275
chr177282883072828914E068-30164
chr177282904072829099E068-29979
chr177282930072829350E068-29728
chr177282956972829981E068-29097
chr177283608372837037E068-22041
chr177283704572837739E068-21339
chr177283774072838106E068-20972
chr177283816472839396E068-19682
chr177280928272809459E069-49619
chr177280946572809552E069-49526
chr177280993772810085E069-48993
chr177281128972811411E069-47667
chr177281152572811636E069-47442
chr177281170072811980E069-47098
chr177281201572812109E069-46969
chr177281216972812442E069-46636
chr177281693372817003E069-42075
chr177281717772817263E069-41815
chr177281738372817433E069-41645
chr177281743472817488E069-41590
chr177281750172817572E069-41506
chr177281765472817726E069-41352
chr177281782872817878E069-41200
chr177281796572818100E069-40978
chr177281828572818355E069-40723
chr177281836372818437E069-40641
chr177281851472818747E069-40331
chr177281877772818834E069-40244
chr177281884072819046E069-40032
chr177281907472819673E069-39405
chr177281973572819794E069-39284
chr177281986072819920E069-39158
chr177282005372820103E069-38975
chr177282013472820174E069-38904
chr177282022672820451E069-38627
chr177282051772820826E069-38252
chr177282085272821007E069-38071
chr177282108272821287E069-37791
chr177282136772821452E069-37626
chr177282159272821642E069-37436
chr177282166772821861E069-37217
chr177282190572821965E069-37113
chr177282214172822416E069-36662
chr177283608372837037E069-22041
chr177283704572837739E069-21339
chr177283774072838106E069-20972
chr177283816472839396E069-19682
chr177285221872852383E069-6695
chr177285296872853008E069-6070
chr177286064272861866E0691564
chr177286724972867874E0698171
chr177286789372868134E0698815
chr177281796572818100E070-40978
chr177281828572818355E070-40723
chr177281836372818437E070-40641
chr177281851472818747E070-40331
chr177281877772818834E070-40244
chr177281884072819046E070-40032
chr177281907472819673E070-39405
chr177281973572819794E070-39284
chr177281986072819920E070-39158
chr177282005372820103E070-38975
chr177282013472820174E070-38904
chr177282022672820451E070-38627
chr177282051772820826E070-38252
chr177282085272821007E070-38071
chr177282108272821287E070-37791
chr177282136772821452E070-37626
chr177282159272821642E070-37436
chr177282166772821861E070-37217
chr177282190572821965E070-37113
chr177282214172822416E070-36662
chr177283562372835690E070-23388
chr177283608372837037E070-22041
chr177283704572837739E070-21339
chr177283774072838106E070-20972
chr177283816472839396E070-19682
chr177285208672852196E070-6882
chr177286789372868134E0708815
chr177280928272809459E071-49619
chr177280946572809552E071-49526
chr177280993772810085E071-48993
chr177281072172810828E071-48250
chr177281170072811980E071-47098
chr177281201572812109E071-46969
chr177281216972812442E071-46636
chr177281660172816701E071-42377
chr177281693372817003E071-42075
chr177281717772817263E071-41815
chr177281738372817433E071-41645
chr177281743472817488E071-41590
chr177281750172817572E071-41506
chr177281765472817726E071-41352
chr177281782872817878E071-41200
chr177281796572818100E071-40978
chr177281828572818355E071-40723
chr177281836372818437E071-40641
chr177281851472818747E071-40331
chr177281877772818834E071-40244
chr177281884072819046E071-40032
chr177281907472819673E071-39405
chr177281986072819920E071-39158
chr177282005372820103E071-38975
chr177282013472820174E071-38904
chr177282022672820451E071-38627
chr177282051772820826E071-38252
chr177282085272821007E071-38071
chr177282108272821287E071-37791
chr177282136772821452E071-37626
chr177282159272821642E071-37436
chr177282166772821861E071-37217
chr177282190572821965E071-37113
chr177282214172822416E071-36662
chr177282259172822787E071-36291
chr177282315872823224E071-35854
chr177283008372830717E071-28361
chr177283074872830947E071-28131
chr177283336272833438E071-25640
chr177283346172833544E071-25534
chr177283363472833689E071-25389
chr177283372572833781E071-25297
chr177283388272833976E071-25102
chr177283608372837037E071-22041
chr177283704572837739E071-21339
chr177283774072838106E071-20972
chr177285208672852196E071-6882
chr177285221872852383E071-6695
chr177286724972867874E0718171
chr177286789372868134E0718815
chr177287902072879356E07119942
chr177288471472884928E07125636
chr177288497072885029E07125892
chr177280928272809459E072-49619
chr177280946572809552E072-49526
chr177280993772810085E072-48993
chr177281072172810828E072-48250
chr177281201572812109E072-46969
chr177281216972812442E072-46636
chr177281245572812546E072-46532
chr177281738372817433E072-41645
chr177281743472817488E072-41590
chr177281750172817572E072-41506
chr177281765472817726E072-41352
chr177281828572818355E072-40723
chr177281836372818437E072-40641
chr177281851472818747E072-40331
chr177281877772818834E072-40244
chr177281884072819046E072-40032
chr177281907472819673E072-39405
chr177281973572819794E072-39284
chr177281986072819920E072-39158
chr177282005372820103E072-38975
chr177282013472820174E072-38904
chr177282022672820451E072-38627
chr177282051772820826E072-38252
chr177282085272821007E072-38071
chr177282108272821287E072-37791
chr177282136772821452E072-37626
chr177282159272821642E072-37436
chr177282166772821861E072-37217
chr177282190572821965E072-37113
chr177282214172822416E072-36662
chr177282259172822787E072-36291
chr177282315872823224E072-35854
chr177282335672823436E072-35642
chr177283008372830717E072-28361
chr177283074872830947E072-28131
chr177283704572837739E072-21339
chr177283774072838106E072-20972
chr177283816472839396E072-19682
chr177285208672852196E072-6882
chr177285221872852383E072-6695
chr177286789372868134E0728815
chr177280928272809459E073-49619
chr177281201572812109E073-46969
chr177281216972812442E073-46636
chr177281717772817263E073-41815
chr177281738372817433E073-41645
chr177281743472817488E073-41590
chr177281750172817572E073-41506
chr177281765472817726E073-41352
chr177281782872817878E073-41200
chr177281796572818100E073-40978
chr177281828572818355E073-40723
chr177281836372818437E073-40641
chr177281907472819673E073-39405
chr177281973572819794E073-39284
chr177281986072819920E073-39158
chr177282005372820103E073-38975
chr177282013472820174E073-38904
chr177282022672820451E073-38627
chr177282051772820826E073-38252
chr177282085272821007E073-38071
chr177282108272821287E073-37791
chr177282136772821452E073-37626
chr177282159272821642E073-37436
chr177282166772821861E073-37217
chr177282190572821965E073-37113
chr177282214172822416E073-36662
chr177282259172822787E073-36291
chr177282315872823224E073-35854
chr177283074872830947E073-28131
chr177283103472831150E073-27928
chr177283363472833689E073-25389
chr177283372572833781E073-25297
chr177283388272833976E073-25102
chr177283418572834235E073-24843
chr177283704572837739E073-21339
chr177283774072838106E073-20972
chr177283816472839396E073-19682
chr177286724972867874E0738171
chr177280928272809459E074-49619
chr177280946572809552E074-49526
chr177280993772810085E074-48993
chr177281072172810828E074-48250
chr177281087372810977E074-48101
chr177281099372811081E074-47997
chr177281113772811213E074-47865
chr177281128972811411E074-47667
chr177281693372817003E074-42075
chr177281717772817263E074-41815
chr177281738372817433E074-41645
chr177281743472817488E074-41590
chr177281750172817572E074-41506
chr177281765472817726E074-41352
chr177281782872817878E074-41200
chr177281796572818100E074-40978
chr177281828572818355E074-40723
chr177281836372818437E074-40641
chr177281851472818747E074-40331
chr177281877772818834E074-40244
chr177281884072819046E074-40032
chr177281907472819673E074-39405
chr177281973572819794E074-39284
chr177281986072819920E074-39158
chr177282005372820103E074-38975
chr177282013472820174E074-38904
chr177282022672820451E074-38627
chr177282051772820826E074-38252
chr177282085272821007E074-38071
chr177282108272821287E074-37791
chr177282136772821452E074-37626
chr177282159272821642E074-37436
chr177282166772821861E074-37217
chr177282190572821965E074-37113
chr177282214172822416E074-36662
chr177282956972829981E074-29097
chr177283008372830717E074-28361
chr177283608372837037E074-22041
chr177283704572837739E074-21339
chr177283774072838106E074-20972
chr177283816472839396E074-19682
chr177286789372868134E0748815
chr177280928272809459E081-49619
chr177280946572809552E081-49526
chr177280993772810085E081-48993
chr177281738372817433E081-41645
chr177281743472817488E081-41590
chr177281750172817572E081-41506
chr177281765472817726E081-41352
chr177281782872817878E081-41200
chr177281796572818100E081-40978
chr177281828572818355E081-40723
chr177281836372818437E081-40641
chr177281851472818747E081-40331
chr177281877772818834E081-40244
chr177281884072819046E081-40032
chr177281907472819673E081-39405
chr177281973572819794E081-39284
chr177281986072819920E081-39158
chr177282005372820103E081-38975
chr177282013472820174E081-38904
chr177282022672820451E081-38627
chr177282051772820826E081-38252
chr177282085272821007E081-38071
chr177282108272821287E081-37791
chr177282136772821452E081-37626
chr177282159272821642E081-37436
chr177282166772821861E081-37217
chr177282190572821965E081-37113
chr177282214172822416E081-36662
chr177282259172822787E081-36291
chr177282315872823224E081-35854
chr177283608372837037E081-22041
chr177283704572837739E081-21339
chr177283774072838106E081-20972
chr177283816472839396E081-19682
chr177285208672852196E081-6882
chr177285221872852383E081-6695
chr177285246772852588E081-6490
chr177285296872853008E081-6070
chr177285335372853519E081-5559
chr177285357072853714E081-5364
chr177285386772853935E081-5143
chr177286789372868134E0818815
chr177287153072872515E08112452
chr177287253872872645E08113460
chr177280928272809459E082-49619
chr177280946572809552E082-49526
chr177280993772810085E082-48993
chr177281782872817878E082-41200
chr177281796572818100E082-40978
chr177281828572818355E082-40723
chr177281836372818437E082-40641
chr177282005372820103E082-38975
chr177282013472820174E082-38904
chr177282022672820451E082-38627
chr177282051772820826E082-38252
chr177282085272821007E082-38071
chr177282108272821287E082-37791
chr177282136772821452E082-37626
chr177282159272821642E082-37436
chr177282166772821861E082-37217
chr177282190572821965E082-37113
chr177282214172822416E082-36662
chr177282259172822787E082-36291
chr177283704572837739E082-21339
chr177283774072838106E082-20972
chr177283816472839396E082-19682
chr177285208672852196E082-6882
chr177285221872852383E082-6695
chr177285246772852588E082-6490
chr177285296872853008E082-6070
chr177285335372853519E082-5559
chr177285357072853714E082-5364
chr177287135472871420E08212276
chr177287153072872515E08212452
chr177287253872872645E08213460










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr177286815372870509E0679075
chr177288925772889317E06730179
chr177288939272889442E06730314
chr177288948572889990E06730407
chr177285565072855757E068-3321
chr177285750372857569E068-1509
chr177286815372870509E0689075
chr177288925772889317E06830179
chr177288939272889442E06830314
chr177288948572889990E06830407
chr177285565072855757E069-3321
chr177285583772857502E069-1576
chr177286815372870509E0699075
chr177288925772889317E06930179
chr177288939272889442E06930314
chr177288948572889990E06930407
chr177284844672849301E070-9777
chr177286815372870509E0709075
chr177288948572889990E07030407
chr177285565072855757E071-3321
chr177286815372870509E0719075
chr177288925772889317E07130179
chr177285565072855757E072-3321
chr177285583772857502E072-1576
chr177286815372870509E0729075
chr177288925772889317E07230179
chr177288939272889442E07230314
chr177288948572889990E07230407
chr177285565072855757E073-3321
chr177285583772857502E073-1576
chr177285750372857569E073-1509
chr177286815372870509E0739075
chr177288925772889317E07330179
chr177288939272889442E07330314
chr177288948572889990E07330407
chr177286815372870509E0749075
chr177284844672849301E082-9777
chr177285565072855757E082-3321
chr177285583772857502E082-1576
chr177285750372857569E082-1509
chr177286815372870509E0829075
chr177288948572889990E08230407