rs7013543

Homo sapiens
C>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0277 (8315/29942,GnomAD)
A=0230 (6722/29118,TOPMED)
A=0189 (949/5008,1000G)
A=0306 (1180/3854,ALSPAC)
A=0319 (1182/3708,TWINSUK)
chr8:15499544 (GRCh38.p7) (8p22)
AD
GWASdb2
1   publication(s)
See rs on genome
6 Enhancers around
13 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.15499544C>A
GRCh37.p13 chr 8NC_000008.10:g.15357053C>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.871A=0.129
1000GenomesAmericanSub694C=0.760A=0.240
1000GenomesEast AsianSub1008C=0.844A=0.156
1000GenomesEuropeSub1006C=0.693A=0.307
1000GenomesGlobalStudy-wide5008C=0.811A=0.189
1000GenomesSouth AsianSub978C=0.850A=0.150
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.694A=0.306
The Genome Aggregation DatabaseAfricanSub8726C=0.831A=0.169
The Genome Aggregation DatabaseAmericanSub838C=0.780A=0.220
The Genome Aggregation DatabaseEast AsianSub1618C=0.862A=0.138
The Genome Aggregation DatabaseEuropeSub18460C=0.654A=0.345
The Genome Aggregation DatabaseGlobalStudy-wide29942C=0.722A=0.277
The Genome Aggregation DatabaseOtherSub300C=0.810A=0.190
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.769A=0.230
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.681A=0.319
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs70135430.00017Alcohol dependence (early age of onset)20201924
rs70135430.00091alcohol dependence20201924

eQTL of rs7013543 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7013543 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr81539953215399720E07042479
chr81539953215399720E08142479
chr81539974815400011E08142695
chr81540053115400665E08143478
chr81539953215399720E08242479
chr81539974815400011E08242695



Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr81539722615398673E06740173
chr81539722615398673E06840173
chr81539722615398673E06940173
chr81539722615398673E07040173
chr81539869315399060E07041640
chr81539722615398673E07140173
chr81539722615398673E07240173
chr81539869315399060E07241640
chr81539722615398673E07340173
chr81539722615398673E07440173
chr81539722615398673E08140173
chr81539722615398673E08240173
chr81539869315399060E08241640