rs7018590

Homo sapiens
A>G
LOC105376108 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0219 (6564/29928,GnomAD)
A==0182 (5314/29118,TOPMED)
A==0141 (705/5008,1000G)
A==0351 (1351/3854,ALSPAC)
A==0342 (1268/3708,TWINSUK)
chr9:81905521 (GRCh38.p7) (9q21.32)
AD
GWASdb2
1   publication(s)
See rs on genome
27 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.81905521A>G
GRCh37.p13 chr 9NC_000009.11:g.84520436A>G

Gene: LOC105376108, uncharacterized LOC105376108(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105376108 transcript variant X7XR_001746773.1:n.N/AIntron Variant
LOC105376108 transcript variant X1XR_001746767.1:n.N/AGenic Downstream Transcript Variant
LOC105376108 transcript variant X2XR_001746768.1:n.N/AGenic Downstream Transcript Variant
LOC105376108 transcript variant X3XR_001746769.1:n.N/AGenic Downstream Transcript Variant
LOC105376108 transcript variant X4XR_001746770.1:n.N/AGenic Downstream Transcript Variant
LOC105376108 transcript variant X5XR_001746771.1:n.N/AGenic Downstream Transcript Variant
LOC105376108 transcript variant X6XR_001746772.1:n.N/AGenic Downstream Transcript Variant
LOC105376108 transcript variant X8XR_001746774.1:n.N/AGenic Downstream Transcript Variant
LOC105376108 transcript variant X9XR_001746775.1:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.015G=0.985
1000GenomesAmericanSub694A=0.180G=0.820
1000GenomesEast AsianSub1008A=0.001G=0.999
1000GenomesEuropeSub1006A=0.322G=0.678
1000GenomesGlobalStudy-wide5008A=0.141G=0.859
1000GenomesSouth AsianSub978A=0.240G=0.760
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.351G=0.649
The Genome Aggregation DatabaseAfricanSub8724A=0.058G=0.942
The Genome Aggregation DatabaseAmericanSub838A=0.140G=0.860
The Genome Aggregation DatabaseEast AsianSub1616A=0.001G=0.999
The Genome Aggregation DatabaseEuropeSub18450A=0.315G=0.684
The Genome Aggregation DatabaseGlobalStudy-wide29928A=0.219G=0.780
The Genome Aggregation DatabaseOtherSub300A=0.380G=0.620
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.182G=0.817
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.342G=0.658
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs70185900.000402alcohol dependence21314694

eQTL of rs7018590 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7018590 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr98450024584500362E069-20074
chr98450045684500740E069-19696
chr98450076484501012E069-19424
chr98450110884501158E069-19278
chr98450132584501568E069-18868
chr98450045684500740E070-19696
chr98450076484501012E070-19424
chr98450110884501158E070-19278
chr98450132584501568E070-18868
chr98450160284501697E070-18739
chr98450172584501818E070-18618
chr98450076484501012E072-19424
chr98450132584501568E072-18868
chr98447389184473978E081-46458
chr98447404784474275E081-46161
chr98447459084474650E081-45786
chr98450045684500740E081-19696
chr98450076484501012E081-19424
chr98450110884501158E081-19278
chr98450132584501568E081-18868
chr98450160284501697E081-18739
chr98450172584501818E081-18618
chr98450199584502063E081-18373
chr98450214484502229E081-18207
chr98450132584501568E082-18868
chr98450160284501697E082-18739
chr98450172584501818E082-18618