rs7038366

Homo sapiens
C>A
KANK1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0292 (8707/29770,GnomAD)
A=0287 (1435/5008,1000G)
A=0159 (613/3854,ALSPAC)
A=0157 (581/3708,TWINSUK)
chr9:515616 (GRCh38.p7) (9p24.3)
ND
GWASdb2
1   publication(s)
See rs on genome
347 Enhancers around
19 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.515616C>A
GRCh37.p13 chr 9NC_000009.11:g.515616C>A
KANK1 RefSeqGeneNG_016331.2:g.50323C>A

Gene: KANK1, KN motif and ankyrin repeat domains 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
KANK1 transcript variant 3NM_001256876.1:c.N/AIntron Variant
KANK1 transcript variant 4NM_001256877.1:c.N/AIntron Variant
KANK1 transcript variant 1NM_015158.3:c.N/AIntron Variant
KANK1 transcript variant 2NM_153186.4:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X2XM_005251411.2:c.N/AIntron Variant
KANK1 transcript variant X5XM_011517819.1:c.N/AIntron Variant
KANK1 transcript variant X4XM_017014513.1:c.N/AIntron Variant
KANK1 transcript variant X10XM_017014515.1:c.N/AIntron Variant
KANK1 transcript variant X13XM_017014518.1:c.N/AIntron Variant
KANK1 transcript variant X15XM_017014520.1:c.N/AIntron Variant
KANK1 transcript variant X18XM_017014523.1:c.N/AIntron Variant
KANK1 transcript variant X29XM_017014528.1:c.N/AIntron Variant
KANK1 transcript variant X24XM_005251414.3:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X22XM_005251415.2:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X26XM_005251416.2:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X23XM_005251417.3:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X25XM_005251418.2:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X27XM_005251419.2:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X8XM_006716743.2:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X6XM_011517820.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X7XM_011517821.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X1XM_017014511.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X3XM_017014512.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X9XM_017014514.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X11XM_017014516.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X12XM_017014517.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X14XM_017014519.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X16XM_017014521.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X17XM_017014522.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X19XM_017014524.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X20XM_017014525.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X21XM_017014526.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X28XM_017014527.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X30XM_017014529.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X31XM_017014530.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X32XM_017014531.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X33XM_017014532.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X34XM_017014533.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X35XM_017014534.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X36XM_017014535.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X37XM_017014536.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X38XM_017014537.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X39XM_017014538.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X41XM_017014539.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X42XM_017014540.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X43XM_017014541.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X44XM_017014542.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X40XR_001746257.1:n.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X45XR_001746258.1:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.259A=0.741
1000GenomesAmericanSub694C=0.870A=0.130
1000GenomesEast AsianSub1008C=0.997A=0.003
1000GenomesEuropeSub1006C=0.858A=0.142
1000GenomesGlobalStudy-wide5008C=0.713A=0.287
1000GenomesSouth AsianSub978C=0.770A=0.230
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.841A=0.159
The Genome Aggregation DatabaseAfricanSub8562C=0.343A=0.657
The Genome Aggregation DatabaseAmericanSub828C=0.900A=0.100
The Genome Aggregation DatabaseEast AsianSub1620C=0.999A=0.001
The Genome Aggregation DatabaseEuropeSub18458C=0.838A=0.161
The Genome Aggregation DatabaseGlobalStudy-wide29770C=0.707A=0.292
The Genome Aggregation DatabaseOtherSub302C=0.920A=0.080
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.843A=0.157
PMID Title Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.Wang KSDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs70383663.37E-06nicotine dependence (smoking)22377092

eQTL of rs7038366 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7038366 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr9513289513339E067-2277
chr9531455531647E06715839
chr9531769531905E06716153
chr9531935532183E06716319
chr9532466532799E06716850
chr9532810533139E06717194
chr9533317533523E06717701
chr9533684533874E06718068
chr9533985534531E06718369
chr9534669534943E06719053
chr9534972535361E06719356
chr9535463535734E06719847
chr9535743535849E06720127
chr9537040537411E06721424
chr9537498537586E06721882
chr9537646537700E06722030
chr9537748537933E06722132
chr9538059538151E06722443
chr9538240538389E06722624
chr9544406544559E06728790
chr9544637544773E06729021
chr9544890545079E06729274
chr9545245545352E06729629
chr9545536545720E06729920
chr9545724545829E06730108
chr9546262547628E06730646
chr9547741547856E06732125
chr9547891548104E06732275
chr9548193548243E06732577
chr9549261549344E06733645
chr9558445558593E06742829
chr9560046560243E06744430
chr9560348560446E06744732
chr9560500560550E06744884
chr9560701560789E06745085
chr9560845561205E06745229
chr9561468561924E06745852
chr9562439562642E06746823
chr9562912563844E06747296
chr9563874564064E06748258
chr9468576468736E068-46880
chr9471212471329E068-44287
chr9471382471521E068-44095
chr9506162506581E068-9035
chr9512982513130E068-2486
chr9513289513339E068-2277
chr9516802516929E0681186
chr9517302517532E0681686
chr9517540517606E0681924
chr9518043518514E0682427
chr9518590518863E0682974
chr9519208519255E0683592
chr9522347522756E0686731
chr9522777522925E0687161
chr9523233523540E0687617
chr9523606523708E0687990
chr9524123524262E0688507
chr9524274524366E0688658
chr9524426524494E0688810
chr9524679524729E0689063
chr9531088531237E06815472
chr9531312531362E06815696
chr9531455531647E06815839
chr9531769531905E06816153
chr9531935532183E06816319
chr9532466532799E06816850
chr9532810533139E06817194
chr9533317533523E06817701
chr9533684533874E06818068
chr9533985534531E06818369
chr9534669534943E06819053
chr9534972535361E06819356
chr9535463535734E06819847
chr9535743535849E06820127
chr9536038536078E06820422
chr9536407536466E06820791
chr9536679536748E06821063
chr9536786536914E06821170
chr9536921537020E06821305
chr9537040537411E06821424
chr9537498537586E06821882
chr9537646537700E06822030
chr9537748537933E06822132
chr9544239544289E06828623
chr9544406544559E06828790
chr9544637544773E06829021
chr9544890545079E06829274
chr9545245545352E06829629
chr9545536545720E06829920
chr9545724545829E06830108
chr9547891548104E06832275
chr9548193548243E06832577
chr9548384548463E06832768
chr9552035552935E06836419
chr9560845561205E06845229
chr9561468561924E06845852
chr9562439562642E06846823
chr9564319564395E06848703
chr9564787564837E06849171
chr9471212471329E069-44287
chr9471382471521E069-44095
chr9512982513130E069-2486
chr9513289513339E069-2277
chr9522777522925E0697161
chr9523233523540E0697617
chr9530500530657E06914884
chr9530714530987E06915098
chr9531088531237E06915472
chr9531312531362E06915696
chr9531455531647E06915839
chr9531769531905E06916153
chr9531935532183E06916319
chr9532466532799E06916850
chr9532810533139E06917194
chr9533317533523E06917701
chr9533684533874E06918068
chr9533985534531E06918369
chr9534669534943E06919053
chr9534972535361E06919356
chr9535743535849E06920127
chr9536921537020E06921305
chr9537040537411E06921424
chr9537498537586E06921882
chr9537646537700E06922030
chr9537748537933E06922132
chr9538059538151E06922443
chr9538240538389E06922624
chr9544239544289E06928623
chr9544406544559E06928790
chr9544637544773E06929021
chr9544890545079E06929274
chr9545245545352E06929629
chr9545536545720E06929920
chr9545724545829E06930108
chr9546262547628E06930646
chr9547741547856E06932125
chr9547891548104E06932275
chr9548193548243E06932577
chr9549261549344E06933645
chr9549370550149E06933754
chr9552035552935E06936419
chr9560348560446E06944732
chr9560500560550E06944884
chr9560701560789E06945085
chr9560845561205E06945229
chr9561468561924E06945852
chr9562439562642E06946823
chr9562912563844E06947296
chr9563874564064E06948258
chr9564319564395E06948703
chr9564787564837E06949171
chr9564856564906E06949240
chr9564910564998E06949294
chr9471212471329E070-44287
chr9471382471521E070-44095
chr9471641471695E070-43921
chr9471788471868E070-43748
chr9534972535361E07019356
chr9471212471329E071-44287
chr9471382471521E071-44095
chr9506162506581E071-9035
chr9506711506889E071-8727
chr9512033512153E071-3463
chr9512320512364E071-3252
chr9512982513130E071-2486
chr9513289513339E071-2277
chr9516612516696E071996
chr9516802516929E0711186
chr9517302517532E0711686
chr9517540517606E0711924
chr9520769520824E0715153
chr9520915520965E0715299
chr9522347522756E0716731
chr9522777522925E0717161
chr9523233523540E0717617
chr9523606523708E0717990
chr9524679524729E0719063
chr9530500530657E07114884
chr9530714530987E07115098
chr9531088531237E07115472
chr9531312531362E07115696
chr9531455531647E07115839
chr9531769531905E07116153
chr9531935532183E07116319
chr9532466532799E07116850
chr9532810533139E07117194
chr9533317533523E07117701
chr9533684533874E07118068
chr9533985534531E07118369
chr9535463535734E07119847
chr9535743535849E07120127
chr9536038536078E07120422
chr9536679536748E07121063
chr9536786536914E07121170
chr9536921537020E07121305
chr9537040537411E07121424
chr9537498537586E07121882
chr9537646537700E07122030
chr9537748537933E07122132
chr9538059538151E07122443
chr9538240538389E07122624
chr9544239544289E07128623
chr9544406544559E07128790
chr9544637544773E07129021
chr9544890545079E07129274
chr9545245545352E07129629
chr9545536545720E07129920
chr9545724545829E07130108
chr9549261549344E07133645
chr9549370550149E07133754
chr9551166551357E07135550
chr9551636551714E07136020
chr9552035552935E07136419
chr9553489553539E07137873
chr9557794558197E07142178
chr9558445558593E07142829
chr9559734560039E07144118
chr9560046560243E07144430
chr9560348560446E07144732
chr9560500560550E07144884
chr9560701560789E07145085
chr9560845561205E07145229
chr9561468561924E07145852
chr9562439562642E07146823
chr9564787564837E07149171
chr9564856564906E07149240
chr9564910564998E07149294
chr9471212471329E072-44287
chr9471382471521E072-44095
chr9503187503271E072-12345
chr9512033512153E072-3463
chr9512320512364E072-3252
chr9512982513130E072-2486
chr9513289513339E072-2277
chr9517302517532E0721686
chr9520769520824E0725153
chr9520915520965E0725299
chr9521278521519E0725662
chr9522777522925E0727161
chr9523233523540E0727617
chr9523606523708E0727990
chr9524123524262E0728507
chr9524274524366E0728658
chr9524426524494E0728810
chr9530714530987E07215098
chr9531088531237E07215472
chr9531312531362E07215696
chr9531455531647E07215839
chr9531769531905E07216153
chr9531935532183E07216319
chr9532466532799E07216850
chr9532810533139E07217194
chr9533317533523E07217701
chr9533684533874E07218068
chr9533985534531E07218369
chr9534669534943E07219053
chr9534972535361E07219356
chr9535463535734E07219847
chr9535743535849E07220127
chr9537646537700E07222030
chr9537748537933E07222132
chr9538059538151E07222443
chr9544890545079E07229274
chr9545245545352E07229629
chr9545536545720E07229920
chr9545724545829E07230108
chr9547891548104E07232275
chr9549261549344E07233645
chr9549370550149E07233754
chr9552035552935E07236419
chr9560845561205E07245229
chr9561468561924E07245852
chr9562439562642E07246823
chr9562912563844E07247296
chr9563874564064E07248258
chr9564319564395E07248703
chr9564787564837E07249171
chr9564856564906E07249240
chr9564910564998E07249294
chr9506162506581E073-9035
chr9522347522756E0736731
chr9522777522925E0737161
chr9532810533139E07317194
chr9533317533523E07317701
chr9533684533874E07318068
chr9534669534943E07319053
chr9534972535361E07319356
chr9535463535734E07319847
chr9535743535849E07320127
chr9536921537020E07321305
chr9537040537411E07321424
chr9544890545079E07329274
chr9545245545352E07329629
chr9545536545720E07329920
chr9545724545829E07330108
chr9546262547628E07330646
chr9471212471329E074-44287
chr9471382471521E074-44095
chr9510944511049E074-4567
chr9511129511189E074-4427
chr9511249511305E074-4311
chr9512033512153E074-3463
chr9512320512364E074-3252
chr9512982513130E074-2486
chr9513289513339E074-2277
chr9521278521519E0745662
chr9522347522756E0746731
chr9522777522925E0747161
chr9531088531237E07415472
chr9531312531362E07415696
chr9531455531647E07415839
chr9531769531905E07416153
chr9531935532183E07416319
chr9532466532799E07416850
chr9532810533139E07417194
chr9533317533523E07417701
chr9533684533874E07418068
chr9533985534531E07418369
chr9534669534943E07419053
chr9534972535361E07419356
chr9535463535734E07419847
chr9535743535849E07420127
chr9536407536466E07420791
chr9536679536748E07421063
chr9536786536914E07421170
chr9536921537020E07421305
chr9537040537411E07421424
chr9537498537586E07421882
chr9538240538389E07422624
chr9544239544289E07428623
chr9544406544559E07428790
chr9544637544773E07429021
chr9544890545079E07429274
chr9545245545352E07429629
chr9545536545720E07429920
chr9545724545829E07430108
chr9546262547628E07430646
chr9547741547856E07432125
chr9547891548104E07432275
chr9548193548243E07432577
chr9552035552935E07436419
chr9562439562642E07446823
chr9529404529454E08113788
chr9529589529642E08113973
chr9546262547628E08130646
chr9547741547856E08132125
chr9552035552935E08136419









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr9469598471163E067-44453
chr9503273506125E067-9491
chr9469598471163E068-44453
chr9503273506125E068-9491
chr9469598471163E069-44453
chr9503273506125E069-9491
chr9469598471163E070-44453
chr9503273506125E070-9491
chr9469598471163E071-44453
chr9503273506125E071-9491
chr9469598471163E072-44453
chr9503273506125E072-9491
chr9469598471163E073-44453
chr9503273506125E073-9491
chr9469598471163E074-44453
chr9503273506125E074-9491
chr9469598471163E081-44453
chr9469598471163E082-44453
chr9503273506125E082-9491