rs7045084

Homo sapiens
C>T
OBP2A : 5 Prime UTR Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0118 (3541/29868,GnomAD)
T=0144 (4194/29118,TOPMED)
T=0145 (724/5008,1000G)
T=0044 (169/3854,ALSPAC)
T=0040 (150/3708,TWINSUK)
chr9:135545890 (GRCh38.p7) (9q34.3)
ND
GWASdb2
1   publication(s)
See rs on genome
35 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.135545890C>T
GRCh37.p13 chr 9NC_000009.11:g.138437736C>T
OBP2A RefSeqGeneNG_029693.1:g.4752C>T

Gene: OBP2A, odorant binding protein 2A(plus strand)

Molecule type Change Amino acid[Codon] SO Term
OBP2A transcript variant gammaNM_001293189.1:c.N/AGenic Upstream Transcript Variant
OBP2A transcript variant deltaNM_001293193.1:c.N/AGenic Upstream Transcript Variant
OBP2A transcript variant alphaNM_014582.2:c.N/AGenic Upstream Transcript Variant
OBP2A transcript variant betaNR_120603.1:n.N/AGenic Upstream Transcript Variant
OBP2A transcript variant X1XM_017014656.1:c.N/A5 Prime UTR Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.726T=0.274
1000GenomesAmericanSub694C=0.870T=0.130
1000GenomesEast AsianSub1008C=0.875T=0.125
1000GenomesEuropeSub1006C=0.938T=0.062
1000GenomesGlobalStudy-wide5008C=0.855T=0.145
1000GenomesSouth AsianSub978C=0.910T=0.090
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.956T=0.044
The Genome Aggregation DatabaseAfricanSub8670C=0.739T=0.261
The Genome Aggregation DatabaseAmericanSub838C=0.890T=0.110
The Genome Aggregation DatabaseEast AsianSub1616C=0.887T=0.113
The Genome Aggregation DatabaseEuropeSub18444C=0.946T=0.053
The Genome Aggregation DatabaseGlobalStudy-wide29868C=0.881T=0.118
The Genome Aggregation DatabaseOtherSub300C=0.970T=0.030
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.856T=0.144
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.960T=0.040
PMID Title Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.Wang KSDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs70450849.92E-05nicotine dependence (smoking)22377092

eQTL of rs7045084 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr9:138437736OBP2AENSG00000122136.9C>T4.9624e-13-249Cerebellum
Chr9:138437736OBP2AENSG00000122136.9C>T2.5740e-8-249Cortex
Chr9:138437736OBP2AENSG00000122136.9C>T5.0885e-6-249Anterior_cingulate_cortex

meQTL of rs7045084 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr9138394106138394367E067-43369
chr9138394399138394522E067-43214
chr9138397031138397280E067-40456
chr9138393929138394038E068-43698
chr9138394106138394367E068-43369
chr9138394399138394522E068-43214
chr9138393929138394038E069-43698
chr9138394106138394367E069-43369
chr9138394399138394522E069-43214
chr9138396279138397024E069-40712
chr9138394627138394762E070-42974
chr9138394765138394825E070-42911
chr9138393929138394038E071-43698
chr9138394106138394367E071-43369
chr9138394399138394522E071-43214
chr9138394627138394762E071-42974
chr9138394765138394825E071-42911
chr9138396279138397024E071-40712
chr9138394399138394522E072-43214
chr9138394627138394762E072-42974
chr9138396279138397024E072-40712
chr9138393929138394038E073-43698
chr9138394106138394367E073-43369
chr9138394399138394522E073-43214
chr9138396279138397024E073-40712
chr9138398094138398190E073-39546
chr9138393929138394038E074-43698
chr9138394106138394367E074-43369
chr9138394399138394522E074-43214
chr9138393929138394038E081-43698
chr9138394106138394367E081-43369
chr9138394399138394522E081-43214
chr9138409236138409286E081-28450
chr9138409521138409590E081-28146
chr9138409696138409736E081-28000









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr9138390781138393839E067-43897
chr9138390781138393839E068-43897
chr9138390781138393839E069-43897
chr9138390781138393839E070-43897
chr9138390781138393839E071-43897
chr9138390781138393839E072-43897
chr9138390781138393839E073-43897
chr9138390781138393839E074-43897
chr9138390781138393839E082-43897