rs7069964

Homo sapiens
C>T
CTNNA3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0163 (4875/29898,GnomAD)
T=0192 (5602/29118,TOPMED)
T=0270 (1351/5008,1000G)
T=0059 (228/3854,ALSPAC)
T=0059 (219/3708,TWINSUK)
chr10:67486714 (GRCh38.p7) (10q21.3)
AD
GWASdb2
1   publication(s)
See rs on genome
53 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.67486714C>T
GRCh37.p13 chr 10NC_000010.10:g.69246472C>T
CTNNA3 RefSeqGeneNG_034072.1:g.214478G>A

Gene: CTNNA3, catenin alpha 3(minus strand)

Molecule type Change Amino acid[Codon] SO Term
CTNNA3 transcript variant 2NM_001127384.2:c.N/AIntron Variant
CTNNA3 transcript variant 3NM_001291133.1:c.N/AIntron Variant
CTNNA3 transcript variant 1NM_013266.3:c.N/AIntron Variant
CTNNA3 transcript variant X1XM_017016151.1:c.N/AIntron Variant
CTNNA3 transcript variant X2XM_017016152.1:c.N/AIntron Variant
CTNNA3 transcript variant X3XM_017016153.1:c.N/AIntron Variant
CTNNA3 transcript variant X8XM_017016158.1:c.N/AIntron Variant
CTNNA3 transcript variant X4XM_017016154.1:c.N/AGenic Upstream Transcript Variant
CTNNA3 transcript variant X5XM_017016155.1:c.N/AGenic Upstream Transcript Variant
CTNNA3 transcript variant X6XM_017016156.1:c.N/AGenic Upstream Transcript Variant
CTNNA3 transcript variant X7XM_017016157.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.615T=0.385
1000GenomesAmericanSub694C=0.820T=0.180
1000GenomesEast AsianSub1008C=0.624T=0.376
1000GenomesEuropeSub1006C=0.939T=0.061
1000GenomesGlobalStudy-wide5008C=0.730T=0.270
1000GenomesSouth AsianSub978C=0.720T=0.280
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.941T=0.059
The Genome Aggregation DatabaseAfricanSub8692C=0.665T=0.335
The Genome Aggregation DatabaseAmericanSub834C=0.830T=0.170
The Genome Aggregation DatabaseEast AsianSub1610C=0.666T=0.334
The Genome Aggregation DatabaseEuropeSub18462C=0.931T=0.068
The Genome Aggregation DatabaseGlobalStudy-wide29898C=0.836T=0.163
The Genome Aggregation DatabaseOtherSub300C=0.920T=0.080
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.807T=0.192
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.941T=0.059
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs70699640.000977alcohol dependence20201924

eQTL of rs7069964 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7069964 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr106923206269232267E067-14205
chr106928063369280970E06734161
chr106928485969284956E06738387
chr106919862969198679E068-47793
chr106919872869198998E068-47474
chr106923206269232267E068-14205
chr106928532569285412E06838853
chr106928563569285697E06839163
chr106928626669286431E06839794
chr106928744769287501E06840975
chr106919803969198303E069-48169
chr106919843769198593E069-47879
chr106919862969198679E069-47793
chr106919872869198998E069-47474
chr106928626669286431E06939794
chr106928670569286755E06940233
chr106919803969198303E071-48169
chr106919843769198593E071-47879
chr106919872869198998E071-47474
chr106919907869199138E071-47334
chr106919915569199208E071-47264
chr106919953869199645E071-46827
chr106923206269232267E071-14205
chr106928063369280970E07134161
chr106928098169281142E07134509
chr106928122569281364E07134753
chr106928563569285697E07139163
chr106928626669286431E07139794
chr106919843769198593E072-47879
chr106919862969198679E072-47793
chr106919872869198998E072-47474
chr106919907869199138E072-47334
chr106919915569199208E072-47264
chr106928063369280970E07234161
chr106928532569285412E07238853
chr106928563569285697E07239163
chr106919803969198303E074-48169
chr106919843769198593E074-47879
chr106919862969198679E074-47793
chr106919872869198998E074-47474
chr106919907869199138E074-47334
chr106919915569199208E074-47264
chr106923189469231988E074-14484
chr106923206269232267E074-14205
chr106928063369280970E07434161
chr106928626669286431E07439794
chr106928670569286755E07440233
chr106921414169214258E081-32214
chr106921429769214359E081-32113
chr106921487669214984E081-31488
chr106921501369215057E081-31415
chr106921532069215370E081-31102
chr106921539869215448E081-31024