rs7076488

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
G==0359 (10760/29912,GnomAD)
G==0351 (10222/29118,TOPMED)
G==0310 (1550/5008,1000G)
G==0388 (1497/3854,ALSPAC)
G==0390 (1446/3708,TWINSUK)
chr10:5291045 (GRCh38.p7) (10p15.1)
AD
GWASdb2
2   publication(s)
See rs on genome
95 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.5291045G>A
GRCh37.p13 chr 10 fix patch HG871_PATCHNW_003871071.1:g.320711G>A
GRCh37.p13 chr 10NC_000010.10:g.5333008G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.272A=0.728
1000GenomesAmericanSub694G=0.470A=0.530
1000GenomesEast AsianSub1008G=0.252A=0.748
1000GenomesEuropeSub1006G=0.401A=0.599
1000GenomesGlobalStudy-wide5008G=0.310A=0.690
1000GenomesSouth AsianSub978G=0.210A=0.790
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.388A=0.612
The Genome Aggregation DatabaseAfricanSub8704G=0.295A=0.705
The Genome Aggregation DatabaseAmericanSub838G=0.460A=0.540
The Genome Aggregation DatabaseEast AsianSub1616G=0.222A=0.778
The Genome Aggregation DatabaseEuropeSub18452G=0.397A=0.602
The Genome Aggregation DatabaseGlobalStudy-wide29912G=0.359A=0.640
The Genome Aggregation DatabaseOtherSub302G=0.360A=0.640
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.351A=0.648
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.390A=0.610
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
23691058Dosage transmission disequilibrium test (dTDT) for linkage and association detection.Zhang ZPLoS One

P-Value

SNP ID p-value Traits Study
rs70764880.00000213alcohol dependence23691058
rs70764880.00042alcohol dependence20201924

eQTL of rs7076488 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr10:5333008TUBAL3ENSG00000178462.7G>A1.5245e-3-113785Hippocampus

meQTL of rs7076488 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr10290440290490E067-30221
chr10290985291116E067-29595
chr10321004321089E067293
chr10338932338982E06718221
chr10339171339221E06718460
chr10339288339338E06718577
chr10339542339638E06718831
chr10340144340306E06719433
chr10343106343831E06722395
chr10343924344003E06723213
chr10344049344318E06723338
chr10338932338982E06818221
chr10339171339221E06818460
chr10339288339338E06818577
chr10339542339638E06818831
chr10340144340306E06819433
chr10343106343831E06822395
chr10343924344003E06823213
chr10344049344318E06823338
chr10344403344453E06823692
chr10344740344858E06824029
chr10287477287640E069-33071
chr10290440290490E069-30221
chr10321004321089E069293
chr10338932338982E06918221
chr10339171339221E06918460
chr10339288339338E06918577
chr10339542339638E06918831
chr10340144340306E06919433
chr10343106343831E06922395
chr10343924344003E06923213
chr10344049344318E06923338
chr10287923288291E070-32420
chr10288443288559E070-32152
chr10321004321089E070293
chr10287477287640E071-33071
chr10321004321089E071293
chr10335847336053E07115136
chr10336089336191E07115378
chr10336373336438E07115662
chr10336950336990E07116239
chr10338932338982E07118221
chr10339171339221E07118460
chr10339288339338E07118577
chr10339542339638E07118831
chr10340144340306E07119433
chr10343106343831E07122395
chr10343924344003E07123213
chr10344049344318E07123338
chr10344403344453E07123692
chr10287477287640E072-33071
chr10290440290490E072-30221
chr10321004321089E072293
chr10328668328794E0727957
chr10338932338982E07218221
chr10339171339221E07218460
chr10339288339338E07218577
chr10339542339638E07218831
chr10340144340306E07219433
chr10343106343831E07222395
chr10343924344003E07223213
chr10344049344318E07223338
chr10344403344453E07223692
chr10339542339638E07318831
chr10340144340306E07319433
chr10343106343831E07322395
chr10287477287640E074-33071
chr10287923288291E074-32420
chr10290440290490E074-30221
chr10317286317666E074-3045
chr10321004321089E074293
chr10335847336053E07415136
chr10336089336191E07415378
chr10336373336438E07415662
chr10338932338982E07418221
chr10339171339221E07418460
chr10339288339338E07418577
chr10339542339638E07418831
chr10340144340306E07419433
chr10343106343831E07422395
chr10343924344003E07423213
chr10344049344318E07423338
chr10344403344453E07423692
chr10344740344858E07424029
chr10287477287640E081-33071
chr10291259291444E081-29267
chr10291506291586E081-29125
chr10291655291723E081-28988
chr10291842292190E081-28521
chr10352079352249E08231368
chr10352252352502E08231541
chr10352608353131E08231897
chr10356266356354E08235555
chr10356392356451E08235681
chr10356518356595E08235807