rs7076488

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G==0359 (10760/29912,GnomAD)
G==0351 (10222/29118,TOPMED)
G==0310 (1550/5008,1000G)
G==0388 (1497/3854,ALSPAC)
G==0390 (1446/3708,TWINSUK)

Position: chr10:5291045 (GRCh38.p7) (10p15.1)

Phenotype: AD

Dataset:

GWASdb2

Publications: 2 publication(s)

Genomic View: See rs on genome

Enhancer: 95 Enhancers around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 10	NC_000010.11:g.5291045G>A
GRCh37.p13 chr 10 fix patch HG871_PATCH	NW_003871071.1:g.320711G>A
GRCh37.p13 chr 10	NC_000010.10:g.5333008G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.272	A=0.728
1000Genomes	American	Sub	694	G=0.470	A=0.530
1000Genomes	East Asian	Sub	1008	G=0.252	A=0.748
1000Genomes	Europe	Sub	1006	G=0.401	A=0.599
1000Genomes	Global	Study-wide	5008	G=0.310	A=0.690
1000Genomes	South Asian	Sub	978	G=0.210	A=0.790
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.388	A=0.612
The Genome Aggregation Database	African	Sub	8704	G=0.295	A=0.705
The Genome Aggregation Database	American	Sub	838	G=0.460	A=0.540
The Genome Aggregation Database	East Asian	Sub	1616	G=0.222	A=0.778
The Genome Aggregation Database	Europe	Sub	18452	G=0.397	A=0.602
The Genome Aggregation Database	Global	Study-wide	29912	G=0.359	A=0.640
The Genome Aggregation Database	Other	Sub	302	G=0.360	A=0.640
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.351	A=0.648
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.390	A=0.610

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res
23691058	Dosage transmission disequilibrium test (dTDT) for linkage and association detection.	Zhang Z	PLoS One

SNP ID	p-value	Traits	Study
rs7076488	0.00000213	alcohol dependence	23691058
rs7076488	0.00042	alcohol dependence	20201924

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
Chr10:5333008	TUBAL3	ENSG00000178462.7	G>A	1.5245e-3	-113785	Hippocampus

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr10	290440	290490	E067	-30221
chr10	290985	291116	E067	-29595
chr10	321004	321089	E067	293
chr10	338932	338982	E067	18221
chr10	339171	339221	E067	18460
chr10	339288	339338	E067	18577
chr10	339542	339638	E067	18831
chr10	340144	340306	E067	19433
chr10	343106	343831	E067	22395
chr10	343924	344003	E067	23213
chr10	344049	344318	E067	23338
chr10	338932	338982	E068	18221
chr10	339171	339221	E068	18460
chr10	339288	339338	E068	18577
chr10	339542	339638	E068	18831
chr10	340144	340306	E068	19433
chr10	343106	343831	E068	22395
chr10	343924	344003	E068	23213
chr10	344049	344318	E068	23338
chr10	344403	344453	E068	23692
chr10	344740	344858	E068	24029
chr10	287477	287640	E069	-33071
chr10	290440	290490	E069	-30221
chr10	321004	321089	E069	293
chr10	338932	338982	E069	18221
chr10	339171	339221	E069	18460
chr10	339288	339338	E069	18577
chr10	339542	339638	E069	18831
chr10	340144	340306	E069	19433
chr10	343106	343831	E069	22395
chr10	343924	344003	E069	23213
chr10	344049	344318	E069	23338
chr10	287923	288291	E070	-32420
chr10	288443	288559	E070	-32152
chr10	321004	321089	E070	293
chr10	287477	287640	E071	-33071
chr10	321004	321089	E071	293
chr10	335847	336053	E071	15136
chr10	336089	336191	E071	15378
chr10	336373	336438	E071	15662
chr10	336950	336990	E071	16239
chr10	338932	338982	E071	18221
chr10	339171	339221	E071	18460
chr10	339288	339338	E071	18577
chr10	339542	339638	E071	18831
chr10	340144	340306	E071	19433
chr10	343106	343831	E071	22395
chr10	343924	344003	E071	23213
chr10	344049	344318	E071	23338
chr10	344403	344453	E071	23692
chr10	287477	287640	E072	-33071
chr10	290440	290490	E072	-30221
chr10	321004	321089	E072	293
chr10	328668	328794	E072	7957
chr10	338932	338982	E072	18221
chr10	339171	339221	E072	18460
chr10	339288	339338	E072	18577
chr10	339542	339638	E072	18831
chr10	340144	340306	E072	19433
chr10	343106	343831	E072	22395
chr10	343924	344003	E072	23213
chr10	344049	344318	E072	23338
chr10	344403	344453	E072	23692
chr10	339542	339638	E073	18831
chr10	340144	340306	E073	19433
chr10	343106	343831	E073	22395
chr10	287477	287640	E074	-33071
chr10	287923	288291	E074	-32420
chr10	290440	290490	E074	-30221
chr10	317286	317666	E074	-3045
chr10	321004	321089	E074	293
chr10	335847	336053	E074	15136
chr10	336089	336191	E074	15378
chr10	336373	336438	E074	15662
chr10	338932	338982	E074	18221
chr10	339171	339221	E074	18460
chr10	339288	339338	E074	18577
chr10	339542	339638	E074	18831
chr10	340144	340306	E074	19433
chr10	343106	343831	E074	22395
chr10	343924	344003	E074	23213
chr10	344049	344318	E074	23338
chr10	344403	344453	E074	23692
chr10	344740	344858	E074	24029
chr10	287477	287640	E081	-33071
chr10	291259	291444	E081	-29267
chr10	291506	291586	E081	-29125
chr10	291655	291723	E081	-28988
chr10	291842	292190	E081	-28521
chr10	352079	352249	E082	31368
chr10	352252	352502	E082	31541
chr10	352608	353131	E082	31897
chr10	356266	356354	E082	35555
chr10	356392	356451	E082	35681
chr10	356518	356595	E082	35807

rs7076488

Genomic Coordinates

Population Frequency

P-Value

eQTL of rs7076488 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs7076488 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)