rs708006

Homo sapiens
C>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0254 (7599/29920,GnomAD)
A=0334 (9733/29118,TOPMED)
A=0271 (1357/5008,1000G)
A=0164 (631/3854,ALSPAC)
A=0167 (621/3708,TWINSUK)
chr6:36966468 (GRCh38.p7) (6p21.2)
AD
GWASdb2
1   publication(s)
See rs on genome
224 Enhancers around
49 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.36966468C>A
GRCh37.p13 chr 6NC_000006.11:g.36934244C>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.406A=0.594
1000GenomesAmericanSub694C=0.760A=0.240
1000GenomesEast AsianSub1008C=0.965A=0.035
1000GenomesEuropeSub1006C=0.811A=0.189
1000GenomesGlobalStudy-wide5008C=0.729A=0.271
1000GenomesSouth AsianSub978C=0.810A=0.190
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.836A=0.164
The Genome Aggregation DatabaseAfricanSub8684C=0.479A=0.521
The Genome Aggregation DatabaseAmericanSub836C=0.800A=0.200
The Genome Aggregation DatabaseEast AsianSub1620C=0.949A=0.051
The Genome Aggregation DatabaseEuropeSub18478C=0.851A=0.148
The Genome Aggregation DatabaseGlobalStudy-wide29920C=0.746A=0.254
The Genome Aggregation DatabaseOtherSub302C=0.720A=0.280
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.665A=0.334
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.833A=0.167
PMID Title Author Journal
19581569Genome-wide association study of alcohol dependence.Treutlein JArch Gen Psychiatry

P-Value

SNP ID p-value Traits Study
rs7080061.09E-06alcohol dependence19581569

eQTL of rs708006 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr6:36934244PI16ENSG00000164530.9C>A1.3916e-812035Cerebellum
Chr6:36934244PI16ENSG00000164530.9C>A2.0302e-1212035Brain_Spinal_cord_cervical
Chr6:36934244PI16ENSG00000164530.9C>A4.9781e-612035Putamen_basal_ganglia

meQTL of rs708006 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr63689197736892258E067-41986
chr63689235536892418E067-41826
chr63689253836892609E067-41635
chr63689292936893024E067-41220
chr63689320336893270E067-40974
chr63691543636915476E067-18768
chr63691552736916181E067-18063
chr63693120336932048E067-2196
chr63694523136945531E06710987
chr63694705536947532E06712811
chr63694773636947786E06713492
chr63694785736947935E06713613
chr63694840436948444E06714160
chr63694864436948718E06714400
chr63694879736949158E06714553
chr63694929136949481E06715047
chr63695060036950705E06716356
chr63695095336951067E06716709
chr63695110836951182E06716864
chr63696203936962093E06727795
chr63696527836965380E06731034
chr63696551336965563E06731269
chr63696564036965755E06731396
chr63696579336966572E06731549
chr63696680736967291E06732563
chr63689197736892258E068-41986
chr63689235536892418E068-41826
chr63689253836892609E068-41635
chr63689292936893024E068-41220
chr63689320336893270E068-40974
chr63689369036893798E068-40446
chr63689451036894754E068-39490
chr63689478636895166E068-39078
chr63689533836895443E068-38801
chr63691232136912404E068-21840
chr63691248936912861E068-21383
chr63691543636915476E068-18768
chr63691552736916181E068-18063
chr63692401436924133E068-10111
chr63692880736928847E068-5397
chr63692909536929145E068-5099
chr63693120336932048E068-2196
chr63693207836932480E068-1764
chr63693252236932792E068-1452
chr63693282536932928E068-1316
chr63693294536933129E068-1115
chr63694705536947532E06812811
chr63694773636947786E06813492
chr63694785736947935E06813613
chr63694840436948444E06814160
chr63694864436948718E06814400
chr63694879736949158E06814553
chr63694929136949481E06815047
chr63695060036950705E06816356
chr63695095336951067E06816709
chr63695110836951182E06816864
chr63696527836965380E06831034
chr63696551336965563E06831269
chr63696564036965755E06831396
chr63696579336966572E06831549
chr63696680736967291E06832563
chr63689141736891467E069-42777
chr63689173936891805E069-42439
chr63689197736892258E069-41986
chr63689235536892418E069-41826
chr63689253836892609E069-41635
chr63689292936893024E069-41220
chr63689533836895443E069-38801
chr63689545736896003E069-38241
chr63689604136896162E069-38082
chr63691715336917298E069-16946
chr63691734336917383E069-16861
chr63691751836917722E069-16522
chr63693120336932048E069-2196
chr63693207836932480E069-1764
chr63694705536947532E06912811
chr63694773636947786E06913492
chr63694785736947935E06913613
chr63694840436948444E06914160
chr63694864436948718E06914400
chr63694879736949158E06914553
chr63694929136949481E06915047
chr63695060036950705E06916356
chr63695095336951067E06916709
chr63695110836951182E06916864
chr63696527836965380E06931034
chr63696551336965563E06931269
chr63696564036965755E06931396
chr63696579336966572E06931549
chr63696680736967291E06932563
chr63693120336932048E070-2196
chr63693207836932480E070-1764
chr63693252236932792E070-1452
chr63694879736949158E07014553
chr63694929136949481E07015047
chr63689197736892258E071-41986
chr63689235536892418E071-41826
chr63689253836892609E071-41635
chr63689292936893024E071-41220
chr63689320336893270E071-40974
chr63689604136896162E071-38082
chr63691543636915476E071-18768
chr63691552736916181E071-18063
chr63691734336917383E071-16861
chr63693120336932048E071-2196
chr63693207836932480E071-1764
chr63693252236932792E071-1452
chr63693282536932928E071-1316
chr63693294536933129E071-1115
chr63694107036941235E0716826
chr63694128036942009E0717036
chr63694705536947532E07112811
chr63694773636947786E07113492
chr63694785736947935E07113613
chr63694840436948444E07114160
chr63694864436948718E07114400
chr63694879736949158E07114553
chr63694929136949481E07115047
chr63695060036950705E07116356
chr63695095336951067E07116709
chr63695110836951182E07116864
chr63696527836965380E07131034
chr63696551336965563E07131269
chr63696564036965755E07131396
chr63696579336966572E07131549
chr63696680736967291E07132563
chr63689197736892258E072-41986
chr63689235536892418E072-41826
chr63689253836892609E072-41635
chr63689292936893024E072-41220
chr63689320336893270E072-40974
chr63689533836895443E072-38801
chr63689545736896003E072-38241
chr63693120336932048E072-2196
chr63694107036941235E0726826
chr63694705536947532E07212811
chr63694773636947786E07213492
chr63694785736947935E07213613
chr63694840436948444E07214160
chr63694864436948718E07214400
chr63694879736949158E07214553
chr63694929136949481E07215047
chr63695060036950705E07216356
chr63695095336951067E07216709
chr63695110836951182E07216864
chr63696551336965563E07231269
chr63696564036965755E07231396
chr63696579336966572E07231549
chr63696680736967291E07232563
chr63689197736892258E073-41986
chr63689235536892418E073-41826
chr63689253836892609E073-41635
chr63689533836895443E073-38801
chr63689545736896003E073-38241
chr63689604136896162E073-38082
chr63689625636896323E073-37921
chr63693060336931156E073-3088
chr63693120336932048E073-2196
chr63694668236946757E07312438
chr63694705536947532E07312811
chr63694773636947786E07313492
chr63694785736947935E07313613
chr63694840436948444E07314160
chr63694864436948718E07314400
chr63694879736949158E07314553
chr63694929136949481E07315047
chr63695060036950705E07316356
chr63695095336951067E07316709
chr63695110836951182E07316864
chr63696527836965380E07331034
chr63696551336965563E07331269
chr63696564036965755E07331396
chr63696579336966572E07331549
chr63696680736967291E07332563
chr63689173936891805E074-42439
chr63689197736892258E074-41986
chr63689235536892418E074-41826
chr63689253836892609E074-41635
chr63689292936893024E074-41220
chr63689320336893270E074-40974
chr63689369036893798E074-40446
chr63689545736896003E074-38241
chr63689604136896162E074-38082
chr63689625636896323E074-37921
chr63691715336917298E074-16946
chr63691734336917383E074-16861
chr63691751836917722E074-16522
chr63691776636917862E074-16382
chr63691791136918045E074-16199
chr63693120336932048E074-2196
chr63693207836932480E074-1764
chr63694107036941235E0746826
chr63694128036942009E0747036
chr63694705536947532E07412811
chr63694773636947786E07413492
chr63694785736947935E07413613
chr63694840436948444E07414160
chr63694864436948718E07414400
chr63694879736949158E07414553
chr63694929136949481E07415047
chr63695060036950705E07416356
chr63695095336951067E07416709
chr63695110836951182E07416864
chr63696527836965380E07431034
chr63696551336965563E07431269
chr63696579336966572E07431549
chr63696680736967291E07432563
chr63693060336931156E081-3088
chr63694705536947532E08112811
chr63694773636947786E08113492
chr63694864436948718E08114400
chr63694879736949158E08114553
chr63696579336966572E08131549
chr63696680736967291E08132563
chr63693060336931156E082-3088
chr63694705536947532E08212811
chr63694773636947786E08213492
chr63694785736947935E08213613
chr63694840436948444E08214160
chr63694864436948718E08214400
chr63694879736949158E08214553
chr63694929136949481E08215047
chr63695110836951182E08216864
chr63696680736967291E08232563










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr63695240636953469E06718162
chr63695348236953533E06719238
chr63695353836955345E06719294
chr63697389736974291E06739653
chr63695240636953469E06818162
chr63695348236953533E06819238
chr63695353836955345E06819294
chr63697389736974291E06839653
chr63697432336974510E06840079
chr63697462436974756E06840380
chr63697483036975180E06840586
chr63697524236975818E06840998
chr63695240636953469E06918162
chr63695348236953533E06919238
chr63695353836955345E06919294
chr63697389736974291E06939653
chr63697432336974510E06940079
chr63695240636953469E07018162
chr63695348236953533E07019238
chr63695353836955345E07019294
chr63695240636953469E07118162
chr63695348236953533E07119238
chr63695353836955345E07119294
chr63697389736974291E07139653
chr63697432336974510E07140079
chr63697462436974756E07140380
chr63697483036975180E07140586
chr63697524236975818E07140998
chr63695240636953469E07218162
chr63695348236953533E07219238
chr63695353836955345E07219294
chr63697389736974291E07239653
chr63697432336974510E07240079
chr63697462436974756E07240380
chr63695240636953469E07318162
chr63695348236953533E07319238
chr63695353836955345E07319294
chr63695240636953469E07418162
chr63695348236953533E07419238
chr63695353836955345E07419294
chr63697389736974291E07439653
chr63697432336974510E07440079
chr63697462436974756E07440380
chr63695240636953469E08118162
chr63695348236953533E08119238
chr63695353836955345E08119294
chr63695240636953469E08218162
chr63695348236953533E08219238
chr63695353836955345E08219294