rs7085106

Homo sapiens
C>T
LOC105376468 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0196 (5885/29908,GnomAD)
T=0197 (5757/29118,TOPMED)
T=0165 (825/5008,1000G)
T=0244 (939/3854,ALSPAC)
T=0242 (899/3708,TWINSUK)
chr10:28445426 (GRCh38.p7) (10p12.1)
ND
GWASdb2
1   publication(s)
See rs on genome
6 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.28445426C>T
GRCh37.p13 chr 10NC_000010.10:g.28734355C>T

Gene: LOC105376468, uncharacterized LOC105376468(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105376468 transcriptNR_134496.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.846T=0.154
1000GenomesAmericanSub694C=0.830T=0.170
1000GenomesEast AsianSub1008C=0.929T=0.071
1000GenomesEuropeSub1006C=0.726T=0.274
1000GenomesGlobalStudy-wide5008C=0.835T=0.165
1000GenomesSouth AsianSub978C=0.840T=0.160
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.756T=0.244
The Genome Aggregation DatabaseAfricanSub8710C=0.856T=0.144
The Genome Aggregation DatabaseAmericanSub828C=0.830T=0.170
The Genome Aggregation DatabaseEast AsianSub1618C=0.914T=0.086
The Genome Aggregation DatabaseEuropeSub18450C=0.768T=0.231
The Genome Aggregation DatabaseGlobalStudy-wide29908C=0.803T=0.196
The Genome Aggregation DatabaseOtherSub302C=0.740T=0.260
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.802T=0.197
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.758T=0.242
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs70851061.7E-05alcohol and nictotine co-dependence20158304

eQTL of rs7085106 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7085106 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr102872081628721618E069-12737
chr102878103228781788E07146677
chr102872081628721618E074-12737
chr102876062928760820E08126274
chr102876085028760916E08126495
chr102876099028761054E08126635