rs7101281

Homo sapiens
T>A
BICC1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0321 (9632/29928,GnomAD)
T==0396 (11551/29118,TOPMED)
T==0338 (1695/5008,1000G)
T==0179 (690/3854,ALSPAC)
T==0200 (740/3708,TWINSUK)
chr10:58661978 (GRCh38.p7) (10q21.1)
ND
GWASdb2
1   publication(s)
See rs on genome
19 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.58661978T>A
GRCh37.p13 chr 10NC_000010.10:g.60421738T>A
BICC1 RefSeqGeneNG_029759.2:g.153835T>A

Gene: BICC1, BicC family RNA binding protein 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
BICC1 transcriptNM_001080512.2:c.N/AIntron Variant
BICC1 transcript variant X4XM_005270169.4:c.N/AIntron Variant
BICC1 transcript variant X1XM_011540185.2:c.N/AIntron Variant
BICC1 transcript variant X1XM_011540188.2:c.N/AIntron Variant
BICC1 transcript variant X2XM_017016677.1:c.N/AIntron Variant
BICC1 transcript variant X4XM_017016678.1:c.N/AIntron Variant
BICC1 transcript variant X6XM_011540189.2:c.N/AGenic Upstream Transcript Variant
BICC1 transcript variant X7XM_011540190.2:c.N/AGenic Upstream Transcript Variant
BICC1 transcript variant X8XM_011540191.2:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.766A=0.234
1000GenomesAmericanSub694T=0.220A=0.780
1000GenomesEast AsianSub1008T=0.121A=0.879
1000GenomesEuropeSub1006T=0.174A=0.826
1000GenomesGlobalStudy-wide5008T=0.338A=0.662
1000GenomesSouth AsianSub978T=0.240A=0.760
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.179A=0.821
The Genome Aggregation DatabaseAfricanSub8704T=0.692A=0.308
The Genome Aggregation DatabaseAmericanSub834T=0.150A=0.850
The Genome Aggregation DatabaseEast AsianSub1616T=0.129A=0.871
The Genome Aggregation DatabaseEuropeSub18474T=0.175A=0.824
The Genome Aggregation DatabaseGlobalStudy-wide29928T=0.321A=0.678
The Genome Aggregation DatabaseOtherSub300T=0.110A=0.890
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.396A=0.603
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.200A=0.800
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs71012810.000223nicotine dependence17158188

eQTL of rs7101281 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7101281 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr106041064960411307E067-10431
chr106039813960398535E068-23203
chr106041064960411307E068-10431
chr106041064960411307E069-10431
chr106041040160410451E070-11287
chr106041053360410583E070-11155
chr106041064960411307E070-10431
chr106041145960411639E070-10099
chr106041173160411781E070-9957
chr106041198260412032E070-9706
chr106045852260458590E07036784
chr106045862160458901E07036883
chr106045904060459092E07037302
chr106041064960411307E071-10431
chr106041064960411307E072-10431
chr106041040160410451E074-11287
chr106041053360410583E074-11155
chr106041064960411307E074-10431
chr106046449260465069E08142754