rs7112005

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0253 (7578/29948,GnomAD)
T==0271 (7913/29118,TOPMED)
T==0260 (1300/5008,1000G)
T==0203 (781/3854,ALSPAC)
T==0193 (714/3708,TWINSUK)
chr11:13217953 (GRCh38.p7) (11p15.3)
AD
GWASdb2
3   publication(s)
See rs on genome
130 Enhancers around
1 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.13217953T>C
GRCh37.p13 chr 11NC_000011.9:g.13239500T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.338C=0.662
1000GenomesAmericanSub694T=0.290C=0.710
1000GenomesEast AsianSub1008T=0.186C=0.814
1000GenomesEuropeSub1006T=0.242C=0.758
1000GenomesGlobalStudy-wide5008T=0.260C=0.740
1000GenomesSouth AsianSub978T=0.230C=0.770
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.203C=0.797
The Genome Aggregation DatabaseAfricanSub8710T=0.302C=0.698
The Genome Aggregation DatabaseAmericanSub838T=0.350C=0.650
The Genome Aggregation DatabaseEast AsianSub1620T=0.158C=0.842
The Genome Aggregation DatabaseEuropeSub18482T=0.234C=0.765
The Genome Aggregation DatabaseGlobalStudy-wide29948T=0.253C=0.747
The Genome Aggregation DatabaseOtherSub298T=0.240C=0.760
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.271C=0.728
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.193C=0.807
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
21302341Replicated genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs.Drgon TAm J Med Genet B Neuropsychiatr Genet
21709609Circadian clock gene polymorphisms and sleep-wake disturbance in Alzheimer disease.Yesavage JAAm J Geriatr Psychiatry

P-Value

SNP ID p-value Traits Study
rs71120050.00035alcohol dependence20201924

eQTL of rs7112005 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7112005 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr111318960113189651E067-49849
chr111318972613190324E067-49176
chr111322875313228821E067-10679
chr111322883313228910E067-10590
chr111322892813230199E067-9301
chr111323021413230357E067-9143
chr111323039913230476E067-9024
chr111323057713230800E067-8700
chr111318960113189651E068-49849
chr111318972613190324E068-49176
chr111319034113190874E068-48626
chr111322696313227434E068-12066
chr111322746013227670E068-11830
chr111322771913227893E068-11607
chr111322792413228022E068-11478
chr111322802613228084E068-11416
chr111322851513228583E068-10917
chr111322875313228821E068-10679
chr111322883313228910E068-10590
chr111323057713230800E068-8700
chr111323085513230949E068-8551
chr111323113013231219E068-8281
chr111323128913231349E068-8151
chr111323139113231521E068-7979
chr111323745913238679E068-821
chr111325923713259301E06819737
chr111325933413259711E06819834
chr111318960113189651E069-49849
chr111318972613190324E069-49176
chr111322621113226261E069-13239
chr111322687013226924E069-12576
chr111322696313227434E069-12066
chr111322746013227670E069-11830
chr111322771913227893E069-11607
chr111322851513228583E069-10917
chr111322875313228821E069-10679
chr111322883313228910E069-10590
chr111322892813230199E069-9301
chr111323021413230357E069-9143
chr111323039913230476E069-9024
chr111323057713230800E069-8700
chr111324380913244212E0694309
chr111324458613245011E0695086
chr111324517213245305E0695672
chr111325115713252322E06911657
chr111318960113189651E070-49849
chr111318972613190324E070-49176
chr111322687013226924E070-12576
chr111322696313227434E070-12066
chr111322746013227670E070-11830
chr111322771913227893E070-11607
chr111322792413228022E070-11478
chr111322892813230199E070-9301
chr111323021413230357E070-9143
chr111323039913230476E070-9024
chr111323057713230800E070-8700
chr111323085513230949E070-8551
chr111324181513241919E0702315
chr111324195613242003E0702456
chr111324458613245011E0705086
chr111324517213245305E0705672
chr111325019913250435E07010699
chr111325052313251129E07011023
chr111325115713252322E07011657
chr111318960113189651E071-49849
chr111318972613190324E071-49176
chr111322687013226924E071-12576
chr111322696313227434E071-12066
chr111322746013227670E071-11830
chr111322771913227893E071-11607
chr111322792413228022E071-11478
chr111322892813230199E071-9301
chr111323021413230357E071-9143
chr111323039913230476E071-9024
chr111323745913238679E071-821
chr111325115713252322E07111657
chr111322696313227434E072-12066
chr111322746013227670E072-11830
chr111322771913227893E072-11607
chr111323021413230357E072-9143
chr111323039913230476E072-9024
chr111323057713230800E072-8700
chr111323181813231933E072-7567
chr111325115713252322E07211657
chr111318960113189651E073-49849
chr111318972613190324E073-49176
chr111322696313227434E073-12066
chr111322746013227670E073-11830
chr111322875313228821E073-10679
chr111322883313228910E073-10590
chr111322892813230199E073-9301
chr111323021413230357E073-9143
chr111323039913230476E073-9024
chr111318960113189651E074-49849
chr111318972613190324E074-49176
chr111322687013226924E074-12576
chr111322696313227434E074-12066
chr111322746013227670E074-11830
chr111322892813230199E074-9301
chr111323021413230357E074-9143
chr111323039913230476E074-9024
chr111323057713230800E074-8700
chr111322696313227434E081-12066
chr111322746013227670E081-11830
chr111322771913227893E081-11607
chr111322792413228022E081-11478
chr111322892813230199E081-9301
chr111323021413230357E081-9143
chr111323039913230476E081-9024
chr111323057713230800E081-8700
chr111324124413241294E0811744
chr111324380913244212E0814309
chr111324458613245011E0815086
chr111324517213245305E0815672
chr111325019913250435E08110699
chr111325052313251129E08111023
chr111325115713252322E08111657
chr111322696313227434E082-12066
chr111322746013227670E082-11830
chr111322771913227893E082-11607
chr111323021413230357E082-9143
chr111323039913230476E082-9024
chr111323057713230800E082-8700
chr111323171213231809E082-7691
chr111323181813231933E082-7567
chr111324380913244212E0824309
chr111324458613245011E0825086
chr111325052313251129E08211023
chr111325115713252322E08211657
chr111325629313256373E08216793










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr111325981513259900E06820315