rs7120605

Homo sapiens
A>G
ARAP1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0150 (4493/29928,GnomAD)
G=0160 (4679/29118,TOPMED)
G=0171 (858/5008,1000G)
G=0090 (348/3854,ALSPAC)
G=0096 (357/3708,TWINSUK)
chr11:72733570 (GRCh38.p7) (11q13.4)
AD
GWASCatalog
1   publication(s)
See rs on genome
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.72733570A>G
GRCh37.p13 chr 11NC_000011.9:g.72444615A>G

Gene: ARAP1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ARAP1 transcript variant 3NM_001040118.2:c.N/AIntron Variant
ARAP1 transcript variant 4NM_001135190.1:c.N/AGenic Upstream Transcript Variant
ARAP1 transcript variant 1NM_015242.4:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.691G=0.309
1000GenomesAmericanSub694A=0.880G=0.120
1000GenomesEast AsianSub1008A=0.893G=0.107
1000GenomesEuropeSub1006A=0.909G=0.091
1000GenomesGlobalStudy-wide5008A=0.829G=0.171
1000GenomesSouth AsianSub978A=0.830G=0.170
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.910G=0.090
The Genome Aggregation DatabaseAfricanSub8704A=0.744G=0.256
The Genome Aggregation DatabaseAmericanSub838A=0.870G=0.130
The Genome Aggregation DatabaseEast AsianSub1622A=0.931G=0.069
The Genome Aggregation DatabaseEuropeSub18462A=0.891G=0.109
The Genome Aggregation DatabaseGlobalStudy-wide29928A=0.849G=0.150
The Genome Aggregation DatabaseOtherSub302A=0.910G=0.090
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.839G=0.160
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.904G=0.096
PMID Title Author Journal
29460428Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.Gelernter JAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs71206059E-06alcohol dependence29460428

eQTL of rs7120605 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr11:72444615ARAP1ENSG00000186635.10A>G1.5430e-6-18833Cerebellum
Chr11:72444615STARD10ENSG00000214530.3A>G2.2288e-6-60111Cerebellum

meQTL of rs7120605 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr117242724972427961E067-16654
chr117242798272428034E067-16581
chr117242804672428185E067-16430
chr117243409172434145E067-10470
chr117243429972434353E067-10262
chr117243443372434523E067-10092
chr117243460572434867E067-9748
chr117243488772435446E067-9169
chr117243591072437176E067-7439
chr117243813372438218E067-6397
chr117243824872438380E067-6235
chr117243867872438944E067-5671
chr117244320972443482E067-1133
chr117244355672443647E067-968
chr117244414772444201E067-414
chr117244423372444304E067-311
chr117244439372444528E067-87
chr117244740572448198E0672790
chr117245156372453766E0676948
chr117245377572453966E0679160
chr117245444372454550E0679828
chr117245461172454892E0679996
chr117245494572455356E06710330
chr117245538972455752E06710774
chr117245581872455925E06711203
chr117245593272456138E06711317
chr117245699072457049E06712375
chr117245705272457131E06712437
chr117245715872457275E06712543
chr117245736872457573E06712753
chr117245777072457973E06713155
chr117245815872458349E06713543
chr117245840872458615E06713793
chr117245863472458709E06714019
chr117245874172458840E06714126
chr117245887372458923E06714258
chr117245900572459085E06714390
chr117245965772459747E06715042
chr117245983572459900E06715220
chr117245994572459995E06715330
chr117246001772460072E06715402
chr117246009872460679E06715483
chr117246440672464773E06719791
chr117246478572465343E06720170
chr117246548372465537E06720868
chr117248224372482293E06737628
chr117248236572482427E06737750
chr117248258372482794E06737968
chr117248289872482962E06738283
chr117248331472483358E06738699
chr117248359072483640E06738975
chr117248373972483789E06739124
chr117248404572484122E06739430
chr117248413572484222E06739520
chr117248423672485136E06739621
chr117248527572485354E06740660
chr117248536072485739E06740745
chr117248583672486087E06741221
chr117248784972488725E06743234
chr117248875472489445E06744139
chr117248950372489744E06744888
chr117248978472489838E06745169
chr117248987272490405E06745257
chr117249079072490864E06746175
chr117249093672491626E06746321
chr117241361572415549E068-29066
chr117242532572425460E068-19155
chr117242548572425641E068-18974
chr117242571472425766E068-18849
chr117242586272425912E068-18703
chr117242594172426021E068-18594
chr117242607872426375E068-18240
chr117242650772426547E068-18068
chr117242671072426818E068-17797
chr117242687472426928E068-17687
chr117242724972427961E068-16654
chr117242798272428034E068-16581
chr117242804672428185E068-16430
chr117242823772428291E068-16324
chr117242837372428435E068-16180
chr117242853472428695E068-15920
chr117242975272430012E068-14603
chr117243007672430904E068-13711
chr117243409172434145E068-10470
chr117243429972434353E068-10262
chr117243443372434523E068-10092
chr117243460572434867E068-9748
chr117243488772435446E068-9169
chr117243813372438218E068-6397
chr117243824872438380E068-6235
chr117243867872438944E068-5671
chr117244320972443482E068-1133
chr117244355672443647E068-968
chr117244414772444201E068-414
chr117244423372444304E068-311
chr117244439372444528E068-87
chr117244664272447135E0682027
chr117244715472447224E0682539
chr117244740572448198E0682790
chr117245056272451500E0685947
chr117245156372453766E0686948
chr117245461172454892E0689996
chr117245494572455356E06810330
chr117245538972455752E06810774
chr117245815872458349E06813543
chr117245840872458615E06813793
chr117245863472458709E06814019
chr117245874172458840E06814126
chr117245887372458923E06814258
chr117245900572459085E06814390
chr117245965772459747E06815042
chr117245983572459900E06815220
chr117245994572459995E06815330
chr117246001772460072E06815402
chr117246009872460679E06815483
chr117246975572470914E06825140
chr117247164272471806E06827027
chr117247185072472454E06827235
chr117248224372482293E06837628
chr117248236572482427E06837750
chr117248258372482794E06837968
chr117248289872482962E06838283
chr117248331472483358E06838699
chr117248359072483640E06838975
chr117248373972483789E06839124
chr117248404572484122E06839430
chr117248413572484222E06839520
chr117248423672485136E06839621
chr117248527572485354E06840660
chr117248536072485739E06840745
chr117248583672486087E06841221
chr117248622172486271E06841606
chr117248627872486360E06841663
chr117248784972488725E06843234
chr117248875472489445E06844139
chr117248950372489744E06844888
chr117248978472489838E06845169
chr117248987272490405E06845257
chr117249047172490521E06845856
chr117249052472490606E06845909
chr117249069172490778E06846076
chr117249079072490864E06846175
chr117249093672491626E06846321
chr117241361572415549E069-29066
chr117242571472425766E069-18849
chr117242586272425912E069-18703
chr117242594172426021E069-18594
chr117242607872426375E069-18240
chr117242798272428034E069-16581
chr117242804672428185E069-16430
chr117242823772428291E069-16324
chr117242837372428435E069-16180
chr117242853472428695E069-15920
chr117242870972429009E069-15606
chr117242904572429308E069-15307
chr117242939872429526E069-15089
chr117242953472429596E069-15019
chr117242962072429670E069-14945
chr117242968272429736E069-14879
chr117242975272430012E069-14603
chr117243007672430904E069-13711
chr117243409172434145E069-10470
chr117243429972434353E069-10262
chr117243443372434523E069-10092
chr117243460572434867E069-9748
chr117243488772435446E069-9169
chr117243550672435843E069-8772
chr117243591072437176E069-7439
chr117243813372438218E069-6397
chr117243824872438380E069-6235
chr117243867872438944E069-5671
chr117244320972443482E069-1133
chr117244355672443647E069-968
chr117244414772444201E069-414
chr117244423372444304E069-311
chr117244439372444528E069-87
chr117244740572448198E0692790
chr117244889972450211E0694284
chr117245023272450363E0695617
chr117245056272451500E0695947
chr117245156372453766E0696948
chr117245377572453966E0699160
chr117245444372454550E0699828
chr117245461172454892E0699996
chr117245494572455356E06910330
chr117245538972455752E06910774
chr117245699072457049E06912375
chr117245705272457131E06912437
chr117245715872457275E06912543
chr117245736872457573E06912753
chr117245777072457973E06913155
chr117245815872458349E06913543
chr117245840872458615E06913793
chr117245863472458709E06914019
chr117245874172458840E06914126
chr117245887372458923E06914258
chr117245900572459085E06914390
chr117245965772459747E06915042
chr117245983572459900E06915220
chr117245994572459995E06915330
chr117246001772460072E06915402
chr117246009872460679E06915483
chr117246440672464773E06919791
chr117246478572465343E06920170
chr117246548372465537E06920868
chr117246556972465609E06920954
chr117246975572470914E06925140
chr117248289872482962E06938283
chr117248331472483358E06938699
chr117248359072483640E06938975
chr117248373972483789E06939124
chr117248404572484122E06939430
chr117248413572484222E06939520
chr117248423672485136E06939621
chr117248527572485354E06940660
chr117248536072485739E06940745
chr117248710072487769E06942485
chr117248784972488725E06943234
chr117248875472489445E06944139
chr117248950372489744E06944888
chr117248978472489838E06945169
chr117248987272490405E06945257
chr117249093672491626E06946321
chr117242594172426021E070-18594
chr117242607872426375E070-18240
chr117242798272428034E070-16581
chr117242804672428185E070-16430
chr117242823772428291E070-16324
chr117242939872429526E070-15089
chr117242953472429596E070-15019
chr117242962072429670E070-14945
chr117242968272429736E070-14879
chr117242975272430012E070-14603
chr117243007672430904E070-13711
chr117246158772461775E07016972
chr117246178472461867E07017169
chr117246187672462093E07017261
chr117249093672491626E07046321
chr117241361572415549E071-29066
chr117241555072415830E071-28785
chr117242323072424269E071-20346
chr117242444572424617E071-19998
chr117242494172425009E071-19606
chr117242503072425096E071-19519
chr117242510172425236E071-19379
chr117242532572425460E071-19155
chr117242548572425641E071-18974
chr117242571472425766E071-18849
chr117242586272425912E071-18703
chr117242594172426021E071-18594
chr117242607872426375E071-18240
chr117242650772426547E071-18068
chr117242671072426818E071-17797
chr117242687472426928E071-17687
chr117242724972427961E071-16654
chr117242798272428034E071-16581
chr117242804672428185E071-16430
chr117242823772428291E071-16324
chr117242837372428435E071-16180
chr117242853472428695E071-15920
chr117242870972429009E071-15606
chr117242904572429308E071-15307
chr117242939872429526E071-15089
chr117242953472429596E071-15019
chr117242962072429670E071-14945
chr117242968272429736E071-14879
chr117242975272430012E071-14603
chr117243409172434145E071-10470
chr117243429972434353E071-10262
chr117243443372434523E071-10092
chr117243460572434867E071-9748
chr117243488772435446E071-9169
chr117243550672435843E071-8772
chr117243591072437176E071-7439
chr117243799272438068E071-6547
chr117243813372438218E071-6397
chr117243824872438380E071-6235
chr117243867872438944E071-5671
chr117243900372439053E071-5562
chr117243909372439301E071-5314
chr117243930672439356E071-5259
chr117244320972443482E071-1133
chr117244355672443647E071-968
chr117244414772444201E071-414
chr117244423372444304E071-311
chr117244439372444528E071-87
chr117244740572448198E0712790
chr117244835872448658E0713743
chr117244878372448847E0714168
chr117244889972450211E0714284
chr117245023272450363E0715617
chr117245056272451500E0715947
chr117245156372453766E0716948
chr117245377572453966E0719160
chr117245403572454267E0719420
chr117245444372454550E0719828
chr117245461172454892E0719996
chr117245494572455356E07110330
chr117245538972455752E07110774
chr117245581872455925E07111203
chr117245593272456138E07111317
chr117245659872456647E07111983
chr117245679772456861E07112182
chr117245691772456964E07112302
chr117245699072457049E07112375
chr117245705272457131E07112437
chr117245715872457275E07112543
chr117245736872457573E07112753
chr117245777072457973E07113155
chr117245815872458349E07113543
chr117245840872458615E07113793
chr117245863472458709E07114019
chr117245874172458840E07114126
chr117245887372458923E07114258
chr117245983572459900E07115220
chr117245994572459995E07115330
chr117246001772460072E07115402
chr117246009872460679E07115483
chr117246440672464773E07119791
chr117246478572465343E07120170
chr117246975572470914E07125140
chr117247164272471806E07127027
chr117247185072472454E07127235
chr117248289872482962E07138283
chr117248331472483358E07138699
chr117248359072483640E07138975
chr117248373972483789E07139124
chr117248404572484122E07139430
chr117248413572484222E07139520
chr117248423672485136E07139621
chr117248527572485354E07140660
chr117248536072485739E07140745
chr117248583672486087E07141221
chr117248622172486271E07141606
chr117248627872486360E07141663
chr117248710072487769E07142485
chr117248784972488725E07143234
chr117248875472489445E07144139
chr117248950372489744E07144888
chr117248978472489838E07145169
chr117248987272490405E07145257
chr117249047172490521E07145856
chr117249052472490606E07145909
chr117249069172490778E07146076
chr117249079072490864E07146175
chr117249093672491626E07146321
chr117242607872426375E072-18240
chr117242650772426547E072-18068
chr117242724972427961E072-16654
chr117242798272428034E072-16581
chr117242804672428185E072-16430
chr117242823772428291E072-16324
chr117242837372428435E072-16180
chr117242853472428695E072-15920
chr117243007672430904E072-13711
chr117243409172434145E072-10470
chr117243429972434353E072-10262
chr117243443372434523E072-10092
chr117243460572434867E072-9748
chr117243488772435446E072-9169
chr117243799272438068E072-6547
chr117243813372438218E072-6397
chr117243824872438380E072-6235
chr117243867872438944E072-5671
chr117244320972443482E072-1133
chr117244355672443647E072-968
chr117244414772444201E072-414
chr117244423372444304E072-311
chr117244439372444528E072-87
chr117244664272447135E0722027
chr117244715472447224E0722539
chr117245023272450363E0725617
chr117245056272451500E0725947
chr117245156372453766E0726948
chr117245377572453966E0729160
chr117245444372454550E0729828
chr117245461172454892E0729996
chr117245494572455356E07210330
chr117245538972455752E07210774
chr117245581872455925E07211203
chr117245593272456138E07211317
chr117245679772456861E07212182
chr117245691772456964E07212302
chr117245699072457049E07212375
chr117245705272457131E07212437
chr117245715872457275E07212543
chr117245736872457573E07212753
chr117245777072457973E07213155
chr117245815872458349E07213543
chr117245840872458615E07213793
chr117245863472458709E07214019
chr117245874172458840E07214126
chr117245887372458923E07214258
chr117245900572459085E07214390
chr117246009872460679E07215483
chr117246440672464773E07219791
chr117246478572465343E07220170
chr117246548372465537E07220868
chr117246556972465609E07220954
chr117246949572469669E07224880
chr117246975572470914E07225140
chr117248236572482427E07237750
chr117248258372482794E07237968
chr117248289872482962E07238283
chr117248331472483358E07238699
chr117248359072483640E07238975
chr117248373972483789E07239124
chr117248404572484122E07239430
chr117248413572484222E07239520
chr117248423672485136E07239621
chr117248527572485354E07240660
chr117248536072485739E07240745
chr117248583672486087E07241221
chr117248622172486271E07241606
chr117248627872486360E07241663
chr117248784972488725E07243234
chr117248875472489445E07244139
chr117248950372489744E07244888
chr117248978472489838E07245169
chr117248987272490405E07245257
chr117249047172490521E07245856
chr117249052472490606E07245909
chr117249069172490778E07246076
chr117249079072490864E07246175
chr117249093672491626E07246321
chr117249409072494605E07249475
chr117242594172426021E073-18594
chr117242607872426375E073-18240
chr117242650772426547E073-18068
chr117242724972427961E073-16654
chr117242798272428034E073-16581
chr117242804672428185E073-16430
chr117242823772428291E073-16324
chr117242837372428435E073-16180
chr117243007672430904E073-13711
chr117243409172434145E073-10470
chr117243429972434353E073-10262
chr117243443372434523E073-10092
chr117243460572434867E073-9748
chr117243488772435446E073-9169
chr117243550672435843E073-8772
chr117243591072437176E073-7439
chr117243867872438944E073-5671
chr117244664272447135E0732027
chr117244715472447224E0732539
chr117244740572448198E0732790
chr117245023272450363E0735617
chr117245056272451500E0735947
chr117245156372453766E0736948
chr117245377572453966E0739160
chr117245403572454267E0739420
chr117245444372454550E0739828
chr117245461172454892E0739996
chr117245494572455356E07310330
chr117245538972455752E07310774
chr117245581872455925E07311203
chr117245593272456138E07311317
chr117245679772456861E07312182
chr117245691772456964E07312302
chr117245699072457049E07312375
chr117245705272457131E07312437
chr117245715872457275E07312543
chr117245736872457573E07312753
chr117245777072457973E07313155
chr117245815872458349E07313543
chr117245840872458615E07313793
chr117245863472458709E07314019
chr117245874172458840E07314126
chr117245887372458923E07314258
chr117245900572459085E07314390
chr117245965772459747E07315042
chr117245983572459900E07315220
chr117245994572459995E07315330
chr117246001772460072E07315402
chr117246009872460679E07315483
chr117246975572470914E07325140
chr117248258372482794E07337968
chr117248289872482962E07338283
chr117248331472483358E07338699
chr117248413572484222E07339520
chr117248423672485136E07339621
chr117248527572485354E07340660
chr117248536072485739E07340745
chr117248583672486087E07341221
chr117248622172486271E07341606
chr117248627872486360E07341663
chr117248710072487769E07342485
chr117248784972488725E07343234
chr117248875472489445E07344139
chr117248950372489744E07344888
chr117248978472489838E07345169
chr117248987272490405E07345257
chr117249047172490521E07345856
chr117249052472490606E07345909
chr117249069172490778E07346076
chr117249079072490864E07346175
chr117249093672491626E07346321
chr117241361572415549E074-29066
chr117242548572425641E074-18974
chr117242571472425766E074-18849
chr117242586272425912E074-18703
chr117242594172426021E074-18594
chr117242607872426375E074-18240
chr117242650772426547E074-18068
chr117242798272428034E074-16581
chr117242804672428185E074-16430
chr117242823772428291E074-16324
chr117242837372428435E074-16180
chr117242853472428695E074-15920
chr117242870972429009E074-15606
chr117242904572429308E074-15307
chr117242939872429526E074-15089
chr117242953472429596E074-15019
chr117242962072429670E074-14945
chr117242968272429736E074-14879
chr117242975272430012E074-14603
chr117243007672430904E074-13711
chr117243409172434145E074-10470
chr117243429972434353E074-10262
chr117243443372434523E074-10092
chr117243460572434867E074-9748
chr117243488772435446E074-9169
chr117243550672435843E074-8772
chr117243591072437176E074-7439
chr117243723172437479E074-7136
chr117243748572437629E074-6986
chr117243783072437927E074-6688
chr117243799272438068E074-6547
chr117243813372438218E074-6397
chr117243824872438380E074-6235
chr117243867872438944E074-5671
chr117243900372439053E074-5562
chr117243909372439301E074-5314
chr117243930672439356E074-5259
chr117244084972441192E074-3423
chr117244122472441327E074-3288
chr117244320972443482E074-1133
chr117244355672443647E074-968
chr117244414772444201E074-414
chr117244423372444304E074-311
chr117244439372444528E074-87
chr117244740572448198E0742790
chr117244835872448658E0743743
chr117244878372448847E0744168
chr117244889972450211E0744284
chr117245023272450363E0745617
chr117245056272451500E0745947
chr117245156372453766E0746948
chr117245377572453966E0749160
chr117245403572454267E0749420
chr117245494572455356E07410330
chr117245538972455752E07410774
chr117245581872455925E07411203
chr117245593272456138E07411317
chr117245679772456861E07412182
chr117245691772456964E07412302
chr117245699072457049E07412375
chr117245705272457131E07412437
chr117245715872457275E07412543
chr117245736872457573E07412753
chr117245777072457973E07413155
chr117245815872458349E07413543
chr117245840872458615E07413793
chr117245863472458709E07414019
chr117245874172458840E07414126
chr117245887372458923E07414258
chr117246001772460072E07415402
chr117246009872460679E07415483
chr117246440672464773E07419791
chr117246975572470914E07425140
chr117248289872482962E07438283
chr117248331472483358E07438699
chr117248359072483640E07438975
chr117248373972483789E07439124
chr117248404572484122E07439430
chr117248413572484222E07439520
chr117248423672485136E07439621
chr117248710072487769E07442485
chr117248784972488725E07443234
chr117248875472489445E07444139
chr117248950372489744E07444888
chr117248978472489838E07445169
chr117248987272490405E07445257
chr117249047172490521E07445856
chr117249052472490606E07445909
chr117249069172490778E07446076
chr117249079072490864E07446175
chr117249093672491626E07446321
chr117239672272396947E081-47668
chr117239701572397856E081-46759
chr117239791072398177E081-46438
chr117239820872398323E081-46292
chr117239835772398407E081-46208
chr117242323072424269E081-20346
chr117242671072426818E081-17797
chr117242687472426928E081-17687
chr117242724972427961E081-16654
chr117242798272428034E081-16581
chr117242804672428185E081-16430
chr117242823772428291E081-16324
chr117242837372428435E081-16180
chr117242853472428695E081-15920
chr117242870972429009E081-15606
chr117242904572429308E081-15307
chr117243007672430904E081-13711
chr117243591072437176E081-7439
chr117243723172437479E081-7136
chr117245461172454892E0819996
chr117245494572455356E08110330
chr117248359072483640E08138975
chr117248373972483789E08139124
chr117248404572484122E08139430
chr117248413572484222E08139520
chr117248423672485136E08139621
chr117248527572485354E08140660
chr117248536072485739E08140745
chr117249093672491626E08146321
chr117249409072494605E08149475
chr117241361572415549E082-29066
chr117241555072415830E082-28785
chr117242724972427961E082-16654
chr117242798272428034E082-16581
chr117242804672428185E082-16430
chr117242823772428291E082-16324
chr117242837372428435E082-16180
chr117243007672430904E082-13711
chr117243591072437176E082-7439
chr117245377572453966E0829160
chr117245403572454267E0829420
chr117245444372454550E0829828
chr117245461172454892E0829996
chr117245494572455356E08210330
chr117246975572470914E08225140
chr117248413572484222E08239520
chr117248423672485136E08239621
chr117248527572485354E08240660
chr117248536072485739E08240745
chr117248583672486087E08241221
chr117249093672491626E08246321










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr117246221472464230E06717599
chr117246221472464230E06817599
chr117246221472464230E06917599
chr117246221472464230E07017599
chr117246221472464230E07117599
chr117246221472464230E07217599
chr117246221472464230E07317599
chr117246221472464230E07417599