SNP Detail Info-rs7137085

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0382 (11440/29874,GnomAD)
A=0416 (12139/29118,TOPMED)
A=0414 (2072/5008,1000G)
A=0337 (1297/3854,ALSPAC)
A=0344 (1274/3708,TWINSUK)

Position: chr12:27932196 (GRCh38.p7) (12p11.22)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 10 Enhancers around

Promoter: 8 Promoters around

Sequence Name	Change(s)
GRCh38.p7 chr 12	NC_000012.12:g.27932196G>A
GRCh37.p13 chr 12	NC_000012.11:g.28085129G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.486	A=0.514
1000Genomes	American	Sub	694	G=0.640	A=0.360
1000Genomes	East Asian	Sub	1008	G=0.561	A=0.439
1000Genomes	Europe	Sub	1006	G=0.641	A=0.359
1000Genomes	Global	Study-wide	5008	G=0.586	A=0.414
1000Genomes	South Asian	Sub	978	G=0.650	A=0.350
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.663	A=0.337
The Genome Aggregation Database	African	Sub	8698	G=0.494	A=0.506
The Genome Aggregation Database	American	Sub	838	G=0.680	A=0.320
The Genome Aggregation Database	East Asian	Sub	1600	G=0.564	A=0.436
The Genome Aggregation Database	Europe	Sub	18436	G=0.677	A=0.322
The Genome Aggregation Database	Global	Study-wide	29874	G=0.617	A=0.382
The Genome Aggregation Database	Other	Sub	302	G=0.600	A=0.400
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.583	A=0.416
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.656	A=0.344

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

SNP ID	p-value	Traits	Study
rs7137085	0.0000338	alcoholism	pha002893
rs7137085	0.000034	alcohol dependence	20201924
rs7137085	0.00037	alcohol dependence(Early Onset)	20201924

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr12	28066985	28067039	E070	-18090
chr12	28067074	28067199	E070	-17930
chr12	28121031	28121390	E071	35902
chr12	28121031	28121390	E072	35902
chr12	28051758	28052738	E081	-32391
chr12	28062490	28062540	E081	-22589
chr12	28066197	28066351	E081	-18778
chr12	28112450	28112535	E081	27321
chr12	28051758	28052738	E082	-32391
chr12	28052796	28052989	E082	-32140

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr12	28121736	28124907	E067	36607
chr12	28121736	28124907	E068	36607
chr12	28121736	28124907	E069	36607
chr12	28121736	28124907	E071	36607
chr12	28121736	28124907	E072	36607
chr12	28121736	28124907	E073	36607
chr12	28121736	28124907	E074	36607
chr12	28121736	28124907	E082	36607

rs7137085