SNP Detail Info-rs7159300

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 14	NC_000014.9:g.72417166G>A
GRCh38.p7 chr 14	NC_000014.9:g.72417166G>T
GRCh37.p13 chr 14	NC_000014.8:g.72883874G>A
GRCh37.p13 chr 14	NC_000014.8:g.72883874G>T
RGS6 RefSeqGene	NG_029236.1:g.490058G>A
RGS6 RefSeqGene	NG_029236.1:g.490058G>T

Gene: RGS6, regulator of G-protein signaling 6(plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
RGS6 transcript variant 1	NM_001204416.2:c.	N/A	Intron Variant
RGS6 transcript variant 3	NM_001204417.2:c.	N/A	Intron Variant
RGS6 transcript variant 4	NM_001204418.2:c.	N/A	Intron Variant
RGS6 transcript variant 5	NM_001204419.2:c.	N/A	Intron Variant
RGS6 transcript variant 6	NM_001204420.2:c.	N/A	Intron Variant
RGS6 transcript variant 7	NM_001204421.2:c.	N/A	Intron Variant
RGS6 transcript variant 8	NM_001204422.2:c.	N/A	Intron Variant
RGS6 transcript variant 9	NM_001204423.1:c.	N/A	Intron Variant
RGS6 transcript variant 10	NM_001204424.1:c.	N/A	Intron Variant
RGS6 transcript variant 2	NM_004296.6:c.	N/A	Intron Variant
RGS6 transcript variant 11	NR_135235.1:n.	N/A	Intron Variant
RGS6 transcript variant X1	XM_017021818.1:c.	N/A	Intron Variant
RGS6 transcript variant X5	XM_017021819.1:c.	N/A	Intron Variant
RGS6 transcript variant X3	XM_017021820.1:c.	N/A	Intron Variant
RGS6 transcript variant X5	XM_017021821.1:c.	N/A	Intron Variant
RGS6 transcript variant X7	XM_017021822.1:c.	N/A	Intron Variant
RGS6 transcript variant X8	XM_017021823.1:c.	N/A	Intron Variant
RGS6 transcript variant X16	XM_017021824.1:c.	N/A	Intron Variant
RGS6 transcript variant X10	XM_017021825.1:c.	N/A	Intron Variant
RGS6 transcript variant X11	XM_017021826.1:c.	N/A	Intron Variant
RGS6 transcript variant X12	XM_017021827.1:c.	N/A	Intron Variant
RGS6 transcript variant X14	XM_017021828.1:c.	N/A	Intron Variant
RGS6 transcript variant X30	XM_017021829.1:c.	N/A	Intron Variant
RGS6 transcript variant X16	XM_017021830.1:c.	N/A	Intron Variant
RGS6 transcript variant X18	XM_017021831.1:c.	N/A	Intron Variant
RGS6 transcript variant X19	XM_017021832.1:c.	N/A	Intron Variant
RGS6 transcript variant X20	XM_017021833.1:c.	N/A	Intron Variant
RGS6 transcript variant X7	XM_011537393.2:c.	N/A	Genic Upstream Transcript Variant
RGS6 transcript variant X12	XM_011537397.1:c.	N/A	Genic Upstream Transcript Variant
RGS6 transcript variant X26	XM_011537407.2:c.	N/A	Genic Upstream Transcript Variant
RGS6 transcript variant X39	XM_017021834.1:c.	N/A	Genic Upstream Transcript Variant
RGS6 transcript variant X17	XR_001750613.1:n.	N/A	Intron Variant

Gene: LOC105370559, uncharacterized LOC105370559(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
LOC105370559 transcript variant X1	XR_001750997.1:n.	N/A	Intron Variant
LOC105370559 transcript variant X2	XR_944018.2:n.	N/A	Intron Variant
LOC105370559 transcript variant X3	XR_944019.2:n.	N/A	Genic Upstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.921	A=0.079
1000Genomes	American	Sub	694	G=0.830	A=0.170
1000Genomes	East Asian	Sub	1008	G=0.809	A=0.191
1000Genomes	Europe	Sub	1006	G=0.759	A=0.241
1000Genomes	Global	Study-wide	5008	G=0.808	A=0.192
1000Genomes	South Asian	Sub	978	G=0.690	A=0.310
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.762	A=0.238
The Genome Aggregation Database	African	Sub	8716	G=0.903	T=0.000
The Genome Aggregation Database	American	Sub	838	G=0.820	T=0.00,
The Genome Aggregation Database	East Asian	Sub	1616	G=0.803	T=0.000
The Genome Aggregation Database	Europe	Sub	18478	G=0.739	T=0.000
The Genome Aggregation Database	Global	Study-wide	29950	G=0.793	T=0.000
The Genome Aggregation Database	Other	Sub	302	G=0.820	T=0.00,
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.824	A=0.175
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.763	A=0.237

PMID	Title	Author	Journal
20811658	Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.	Uhl GR	Mol Med

P-Value

SNP ID	p-value	Traits	Study
rs7159300	4E-06	Smoking cessation	20811658

eQTL of rs7159300 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs7159300 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

rs7159300

Genomic Coordinates

Gene: RGS6, regulator of G-protein signaling 6(plus strand)

Gene: LOC105370559, uncharacterized LOC105370559(minus strand)

Population Frequency

P-Value

eQTL of rs7159300 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs7159300 in Fetal Brain

Genomic View

Chromatin Interaction