rs7159300

Homo sapiens
G>A / G>T
RGS6 : Intron Variant
LOC105370559 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0206 (6174/29950,GnomAD)
A=0175 (5112/29118,TOPMED)
A=0192 (960/5008,1000G)
A=0238 (916/3854,ALSPAC)
A=0237 (879/3708,TWINSUK)
chr14:72417166 (GRCh38.p7) (14q24.2)
ND
GWASCatalog
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.72417166G>A
GRCh38.p7 chr 14NC_000014.9:g.72417166G>T
GRCh37.p13 chr 14NC_000014.8:g.72883874G>A
GRCh37.p13 chr 14NC_000014.8:g.72883874G>T
RGS6 RefSeqGeneNG_029236.1:g.490058G>A
RGS6 RefSeqGeneNG_029236.1:g.490058G>T

Gene: RGS6, regulator of G-protein signaling 6(plus strand)

Molecule type Change Amino acid[Codon] SO Term
RGS6 transcript variant 1NM_001204416.2:c.N/AIntron Variant
RGS6 transcript variant 3NM_001204417.2:c.N/AIntron Variant
RGS6 transcript variant 4NM_001204418.2:c.N/AIntron Variant
RGS6 transcript variant 5NM_001204419.2:c.N/AIntron Variant
RGS6 transcript variant 6NM_001204420.2:c.N/AIntron Variant
RGS6 transcript variant 7NM_001204421.2:c.N/AIntron Variant
RGS6 transcript variant 8NM_001204422.2:c.N/AIntron Variant
RGS6 transcript variant 9NM_001204423.1:c.N/AIntron Variant
RGS6 transcript variant 10NM_001204424.1:c.N/AIntron Variant
RGS6 transcript variant 2NM_004296.6:c.N/AIntron Variant
RGS6 transcript variant 11NR_135235.1:n.N/AIntron Variant
RGS6 transcript variant X1XM_017021818.1:c.N/AIntron Variant
RGS6 transcript variant X5XM_017021819.1:c.N/AIntron Variant
RGS6 transcript variant X3XM_017021820.1:c.N/AIntron Variant
RGS6 transcript variant X5XM_017021821.1:c.N/AIntron Variant
RGS6 transcript variant X7XM_017021822.1:c.N/AIntron Variant
RGS6 transcript variant X8XM_017021823.1:c.N/AIntron Variant
RGS6 transcript variant X16XM_017021824.1:c.N/AIntron Variant
RGS6 transcript variant X10XM_017021825.1:c.N/AIntron Variant
RGS6 transcript variant X11XM_017021826.1:c.N/AIntron Variant
RGS6 transcript variant X12XM_017021827.1:c.N/AIntron Variant
RGS6 transcript variant X14XM_017021828.1:c.N/AIntron Variant
RGS6 transcript variant X30XM_017021829.1:c.N/AIntron Variant
RGS6 transcript variant X16XM_017021830.1:c.N/AIntron Variant
RGS6 transcript variant X18XM_017021831.1:c.N/AIntron Variant
RGS6 transcript variant X19XM_017021832.1:c.N/AIntron Variant
RGS6 transcript variant X20XM_017021833.1:c.N/AIntron Variant
RGS6 transcript variant X7XM_011537393.2:c.N/AGenic Upstream Transcript Variant
RGS6 transcript variant X12XM_011537397.1:c.N/AGenic Upstream Transcript Variant
RGS6 transcript variant X26XM_011537407.2:c.N/AGenic Upstream Transcript Variant
RGS6 transcript variant X39XM_017021834.1:c.N/AGenic Upstream Transcript Variant
RGS6 transcript variant X17XR_001750613.1:n.N/AIntron Variant

Gene: LOC105370559, uncharacterized LOC105370559(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105370559 transcript variant X1XR_001750997.1:n.N/AIntron Variant
LOC105370559 transcript variant X2XR_944018.2:n.N/AIntron Variant
LOC105370559 transcript variant X3XR_944019.2:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.921A=0.079
1000GenomesAmericanSub694G=0.830A=0.170
1000GenomesEast AsianSub1008G=0.809A=0.191
1000GenomesEuropeSub1006G=0.759A=0.241
1000GenomesGlobalStudy-wide5008G=0.808A=0.192
1000GenomesSouth AsianSub978G=0.690A=0.310
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.762A=0.238
The Genome Aggregation DatabaseAfricanSub8716G=0.903T=0.000
The Genome Aggregation DatabaseAmericanSub838G=0.820T=0.00,
The Genome Aggregation DatabaseEast AsianSub1616G=0.803T=0.000
The Genome Aggregation DatabaseEuropeSub18478G=0.739T=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29950G=0.793T=0.000
The Genome Aggregation DatabaseOtherSub302G=0.820T=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.824A=0.175
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.763A=0.237
PMID Title Author Journal
20811658Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.Uhl GRMol Med

P-Value

SNP ID p-value Traits Study
rs71593004E-06Smoking cessation20811658

eQTL of rs7159300 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7159300 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.