rs7164726

Homo sapiens
C>T
FAM81A : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0201 (6025/29942,GnomAD)
T=0311 (1558/5008,1000G)
T=0098 (378/3854,ALSPAC)
T=0104 (386/3708,TWINSUK)
chr15:59423467 (GRCh38.p7) (15q22.2)
AD
GWASdb2
1   publication(s)
See rs on genome
50 Enhancers around
13 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.59423467C>T
GRCh37.p13 chr 15NC_000015.9:g.59715666C>T

Gene: FAM81A, family with sequence similarity 81 member A(plus strand)

Molecule type Change Amino acid[Codon] SO Term
FAM81A transcriptNM_152450.2:c.N/AGenic Upstream Transcript Variant
FAM81A transcript variant X8XM_006720399.2:c.N/AIntron Variant
FAM81A transcript variant X4XM_011521248.2:c.N/AIntron Variant
FAM81A transcript variant X2XM_005254166.2:c.N/AGenic Upstream Transcript Variant
FAM81A transcript variant X6XM_006720398.3:c.N/AGenic Upstream Transcript Variant
FAM81A transcript variant X1XM_011521247.2:c.N/AGenic Upstream Transcript Variant
FAM81A transcript variant X7XM_011521249.2:c.N/AGenic Upstream Transcript Variant
FAM81A transcript variant X9XM_011521250.2:c.N/AGenic Upstream Transcript Variant
FAM81A transcript variant X3XM_017021931.1:c.N/AGenic Upstream Transcript Variant
FAM81A transcript variant X5XM_017021932.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.609T=0.391
1000GenomesAmericanSub694C=0.810T=0.190
1000GenomesEast AsianSub1008C=0.555T=0.445
1000GenomesEuropeSub1006C=0.884T=0.116
1000GenomesGlobalStudy-wide5008C=0.689T=0.311
1000GenomesSouth AsianSub978C=0.650T=0.350
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.902T=0.098
The Genome Aggregation DatabaseAfricanSub8702C=0.648T=0.352
The Genome Aggregation DatabaseAmericanSub838C=0.820T=0.180
The Genome Aggregation DatabaseEast AsianSub1606C=0.571T=0.429
The Genome Aggregation DatabaseEuropeSub18494C=0.889T=0.110
The Genome Aggregation DatabaseGlobalStudy-wide29942C=0.798T=0.201
The Genome Aggregation DatabaseOtherSub302C=0.760T=0.240
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.896T=0.104
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs71647260.00053alcohol dependence(early age of onset)20201924
rs71647260.0006alcohol dependence20201924

eQTL of rs7164726 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7164726 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr155973602759736255E06720361
chr155973632159736533E06720655
chr155969223759692680E068-22986
chr155969272859692913E068-22753
chr155969292659693023E068-22643
chr155969337959693903E068-21763
chr155973412359734203E06818457
chr155973566059735736E06819994
chr155969272859692913E069-22753
chr155969292659693023E069-22643
chr155973888359738960E06923217
chr155973910659739156E06923440
chr155973917159739225E06923505
chr155973953359739629E06923867
chr155969272859692913E070-22753
chr155969292659693023E070-22643
chr155969337959693903E070-21763
chr155969405759694205E070-21461
chr155969420759694288E070-21378
chr155969451159694641E070-21025
chr155969148159692226E071-23440
chr155969223759692680E071-22986
chr155969272859692913E071-22753
chr155969292659693023E071-22643
chr155969337959693903E071-21763
chr155969847459698514E071-17152
chr155973888359738960E07123217
chr155973953359739629E07123867
chr155969148159692226E072-23440
chr155973566059735736E07319994
chr155973577959735943E07320113
chr155973602759736255E07320361
chr155973632159736533E07320655
chr155973828459738334E07322618
chr155973910659739156E07323440
chr155973917159739225E07323505
chr155969148159692226E074-23440
chr155969223759692680E074-22986
chr155969272859692913E074-22753
chr155969292659693023E074-22643
chr155970897559709490E081-6176
chr155970955159709601E081-6065
chr155971211759712174E081-3492
chr155972870059728755E08113034
chr155973196359732029E08116297
chr155973602759736255E08120361
chr155973632159736533E08120655
chr155969405759694205E082-21461
chr155969420759694288E082-21378
chr155969451159694641E082-21025










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr155972893759731497E06713271
chr155973151059731644E06715844
chr155972893759731497E06813271
chr155972893759731497E06913271
chr155972893759731497E07013271
chr155972893759731497E07113271
chr155972893759731497E07213271
chr155973151059731644E07215844
chr155972893759731497E07313271
chr155972893759731497E07413271
chr155972893759731497E08113271
chr155972893759731497E08213271
chr155973151059731644E08215844