rs7170453

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0226 (6782/29912,GnomAD)
C==0264 (7709/29118,TOPMED)
C==0366 (1834/5008,1000G)
C==0115 (444/3854,ALSPAC)
C==0110 (409/3708,TWINSUK)
chr15:53228348 (GRCh38.p7) (15q21.3)
ND
GWASdb2
1   publication(s)
See rs on genome
4 Enhancers around
13 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.53228348C>T
GRCh37.p13 chr 15NC_000015.9:g.53520545C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.462T=0.538
1000GenomesAmericanSub694C=0.220T=0.780
1000GenomesEast AsianSub1008C=0.621T=0.379
1000GenomesEuropeSub1006C=0.112T=0.888
1000GenomesGlobalStudy-wide5008C=0.366T=0.634
1000GenomesSouth AsianSub978C=0.340T=0.660
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.115T=0.885
The Genome Aggregation DatabaseAfricanSub8690C=0.389T=0.611
The Genome Aggregation DatabaseAmericanSub838C=0.300T=0.700
The Genome Aggregation DatabaseEast AsianSub1606C=0.636T=0.364
The Genome Aggregation DatabaseEuropeSub18476C=0.112T=0.887
The Genome Aggregation DatabaseGlobalStudy-wide29912C=0.226T=0.773
The Genome Aggregation DatabaseOtherSub302C=0.170T=0.830
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.264T=0.735
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.110T=0.890
PMID Title Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.Wang KSDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs71704533.72E-05nicotine dependence (smoking)22377092

eQTL of rs7170453 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7170453 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr155356072953560807E07040184
chr155356088553560929E07040340
chr155356129753561381E07040752
chr155349012453490329E071-30216


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr155348947053489553E067-30992
chr155348957453489986E067-30559
chr155348947053489553E068-30992
chr155348957453489986E068-30559
chr155348947053489553E070-30992
chr155348957453489986E070-30559
chr155348947053489553E071-30992
chr155348957453489986E071-30559
chr155348947053489553E072-30992
chr155348957453489986E072-30559
chr155348947053489553E073-30992
chr155348947053489553E082-30992
chr155348957453489986E082-30559