rs7173851

Homo sapiens
T>G
WDR61 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0492 (14732/29946,GnomAD)
T==0473 (13774/29118,TOPMED)
T==0499 (2500/5008,1000G)
G=0489 (1884/3854,ALSPAC)
T==0497 (1843/3708,TWINSUK)
chr15:78286317 (GRCh38.p7) (15q25.1)
AD
GWASdb2
1   publication(s)
See rs on genome
112 Enhancers around
17 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.78286317T>G
GRCh37.p13 chr 15NC_000015.9:g.78578659T>G

Gene: WDR61, WD repeat domain 61(minus strand)

Molecule type Change Amino acid[Codon] SO Term
WDR61 transcript variant 1NM_001303247.1:c.N/AIntron Variant
WDR61 transcript variant 3NM_001303248.1:c.N/AIntron Variant
WDR61 transcript variant 2NM_025234.2:c.N/AIntron Variant
WDR61 transcript variant X1XM_011522094.1:c.N/AIntron Variant
WDR61 transcript variant X3XM_017022637.1:c.N/AIntron Variant
WDR61 transcript variant X4XR_001751403.1:n.N/AIntron Variant
WDR61 transcript variant X2XR_931918.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.451G=0.549
1000GenomesAmericanSub694T=0.420G=0.580
1000GenomesEast AsianSub1008T=0.614G=0.386
1000GenomesEuropeSub1006T=0.483G=0.517
1000GenomesGlobalStudy-wide5008T=0.499G=0.501
1000GenomesSouth AsianSub978T=0.520G=0.480
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.511G=0.489
The Genome Aggregation DatabaseAfricanSub8704T=0.451G=0.549
The Genome Aggregation DatabaseAmericanSub838T=0.430G=0.570
The Genome Aggregation DatabaseEast AsianSub1622T=0.594G=0.406
The Genome Aggregation DatabaseEuropeSub18480T=0.507G=0.492
The Genome Aggregation DatabaseGlobalStudy-wide29946T=0.492G=0.508
The Genome Aggregation DatabaseOtherSub302T=0.370G=0.630
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.473G=0.527
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.497G=0.503
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs71738510.000575alcohol dependence24277619

eQTL of rs7173851 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr15:78578659RP11-762H8.2ENSG00000259562.2T>G5.2302e-9-4904Cerebellum
Chr15:78578659RP11-762H8.2ENSG00000259562.2T>G2.4133e-7-4904Cortex
Chr15:78578659RP11-762H8.2ENSG00000259562.2T>G1.0775e-7-4904Cerebellar_Hemisphere
Chr15:78578659RP11-762H8.2ENSG00000259562.2T>G8.4070e-6-4904Putamen_basal_ganglia

meQTL of rs7173851 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr157854860778548845E067-29814
chr157854930478549392E067-29267
chr157854963978549753E067-28906
chr157854976378550704E067-27955
chr157855395278554055E067-24604
chr157855909678559179E067-19480
chr157859043878590542E06711779
chr157859076578590820E06712106
chr157860808278609903E06729423
chr157855197978552064E068-26595
chr157855215278552229E068-26430
chr157855258378552690E068-25969
chr157855279178553030E068-25629
chr157855395278554055E068-24604
chr157855612878556251E068-22408
chr157855970378559829E068-18830
chr157860808278609903E06829423
chr157853559278536443E069-42216
chr157854860778548845E069-29814
chr157854930478549392E069-29267
chr157854963978549753E069-28906
chr157854976378550704E069-27955
chr157855075378550837E069-27822
chr157855087678551032E069-27627
chr157855130178551344E069-27315
chr157855169178551936E069-26723
chr157855197978552064E069-26595
chr157855215278552229E069-26430
chr157855258378552690E069-25969
chr157855279178553030E069-25629
chr157855395278554055E069-24604
chr157855909678559179E069-19480
chr157855924378559320E069-19339
chr157855970378559829E069-18830
chr157856474578565766E069-12893
chr157860808278609903E06929423
chr157859076578590820E07012106
chr157861460278615245E07035943
chr157861536278615672E07036703
chr157861568778615879E07037028
chr157853306778533760E071-44899
chr157854860778548845E071-29814
chr157854930478549392E071-29267
chr157854963978549753E071-28906
chr157854976378550704E071-27955
chr157855130178551344E071-27315
chr157855169178551936E071-26723
chr157855197978552064E071-26595
chr157855215278552229E071-26430
chr157855258378552690E071-25969
chr157855279178553030E071-25629
chr157855395278554055E071-24604
chr157855612878556251E071-22408
chr157855909678559179E071-19480
chr157855924378559320E071-19339
chr157856474578565766E071-12893
chr157859043878590542E07111779
chr157859076578590820E07112106
chr157860079878601294E07122139
chr157860808278609903E07129423
chr157853644578536529E072-42130
chr157853653978536776E072-41883
chr157853678178536835E072-41824
chr157854963978549753E072-28906
chr157855130178551344E072-27315
chr157855169178551936E072-26723
chr157855197978552064E072-26595
chr157855215278552229E072-26430
chr157855258378552690E072-25969
chr157855279178553030E072-25629
chr157855924378559320E072-19339
chr157855970378559829E072-18830
chr157856474578565766E072-12893
chr157857182078571889E072-6770
chr157857213778572187E072-6472
chr157859076578590820E07212106
chr157860808278609903E07229423
chr157853306778533760E073-44899
chr157853644578536529E073-42130
chr157853653978536776E073-41883
chr157853678178536835E073-41824
chr157854976378550704E073-27955
chr157855924378559320E073-19339
chr157855970378559829E073-18830
chr157860808278609903E07329423
chr157853559278536443E074-42216
chr157853644578536529E074-42130
chr157853653978536776E074-41883
chr157853678178536835E074-41824
chr157854963978549753E074-28906
chr157854976378550704E074-27955
chr157855075378550837E074-27822
chr157855087678551032E074-27627
chr157855130178551344E074-27315
chr157855169178551936E074-26723
chr157855197978552064E074-26595
chr157855215278552229E074-26430
chr157855258378552690E074-25969
chr157855279178553030E074-25629
chr157855395278554055E074-24604
chr157860079878601294E07422139
chr157860132278601544E07422663
chr157860808278609903E07429423
chr157855909678559179E081-19480
chr157855924378559320E081-19339
chr157861460278615245E08135943
chr157855909678559179E082-19480
chr157855924378559320E082-19339
chr157856474578565766E082-12893
chr157859043878590542E08211779
chr157859076578590820E08212106
chr157861460278615245E08235943










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr157855628778559032E067-19627
chr157859129478592623E06712635
chr157855628778559032E068-19627
chr157859129478592623E06812635
chr157855628778559032E069-19627
chr157859129478592623E06912635
chr157855628778559032E070-19627
chr157859129478592623E07012635
chr157855628778559032E071-19627
chr157859129478592623E07112635
chr157855628778559032E072-19627
chr157859129478592623E07212635
chr157855628778559032E073-19627
chr157859129478592623E07312635
chr157855628778559032E074-19627
chr157859129478592623E07412635
chr157859129478592623E08212635