rs7181250

Homo sapiens
T>C
LOC105370777 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0330 (9877/29928,GnomAD)
C=0330 (9627/29118,TOPMED)
C=0248 (1240/5008,1000G)
C=0436 (1680/3854,ALSPAC)
C=0424 (1572/3708,TWINSUK)
chr15:39330392 (GRCh38.p7) (15q14)
AD
GWASdb2
1   publication(s)
See rs on genome
10 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.39330392T>C
GRCh37.p13 chr 15NC_000015.9:g.39622593T>C

Gene: LOC105370777, uncharacterized LOC105370777(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105370777 transcript variant X3XR_001751491.1:n.N/AIntron Variant
LOC105370777 transcript variant X1XR_001751489.1:n.N/AGenic Upstream Transcript Variant
LOC105370777 transcript variant X2XR_001751490.1:n.N/AGenic Upstream Transcript Variant
LOC105370777 transcript variant X4XR_001751492.1:n.N/AGenic Upstream Transcript Variant
LOC105370777 transcript variant X5XR_932144.2:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.784C=0.216
1000GenomesAmericanSub694T=0.710C=0.290
1000GenomesEast AsianSub1008T=0.888C=0.112
1000GenomesEuropeSub1006T=0.592C=0.408
1000GenomesGlobalStudy-wide5008T=0.752C=0.248
1000GenomesSouth AsianSub978T=0.760C=0.240
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.564C=0.436
The Genome Aggregation DatabaseAfricanSub8710T=0.763C=0.237
The Genome Aggregation DatabaseAmericanSub838T=0.730C=0.270
The Genome Aggregation DatabaseEast AsianSub1618T=0.875C=0.125
The Genome Aggregation DatabaseEuropeSub18460T=0.608C=0.391
The Genome Aggregation DatabaseGlobalStudy-wide29928T=0.670C=0.330
The Genome Aggregation DatabaseOtherSub302T=0.500C=0.500
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.669C=0.330
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.576C=0.424
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs71812500.000702alcohol dependence21314694

eQTL of rs7181250 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7181250 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr153965485639655855E07032263
chr153959628639597246E081-25347
chr153961868639618904E081-3689
chr153961893339619555E081-3038
chr153962697039627778E0814377
chr153959628639597246E082-25347
chr153961868639618904E082-3689
chr153961893339619555E082-3038
chr153961969739619771E082-2822
chr153961994939620267E082-2326