rs7192628

Organism: Homo sapiens

Alleles: C>T

Gene : Feature

ZCCHC14 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

C==0179 (5370/29958,GnomAD)
C==0169 (4928/29118,TOPMED)
C==0248 (1240/5008,1000G)
C==0158 (608/3854,ALSPAC)
C==0154 (572/3708,TWINSUK)

Position: chr16:87461252 (GRCh38.p7) (16q24.2)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 357 Enhancers around

Promoter: 45 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 16	NC_000016.10:g.87461252C>T
GRCh37.p13 chr 16	NC_000016.9:g.87494858C>T

Gene: ZCCHC14, zinc finger CCHC-type containing 14(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ZCCHC14 transcript	NM_015144.2:c.	N/A	Intron Variant
ZCCHC14 transcript variant X1	XM_005255858.3:c.	N/A	Intron Variant
ZCCHC14 transcript variant X4	XM_011522964.2:c.	N/A	Intron Variant
ZCCHC14 transcript variant X3	XM_017023082.1:c.	N/A	Intron Variant
ZCCHC14 transcript variant X2	XR_243401.3:n.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	C=0.150	T=0.850
1000Genomes	American	Sub	694	C=0.370	T=0.630
1000Genomes	East Asian	Sub	1008	C=0.468	T=0.532
1000Genomes	Europe	Sub	1006	C=0.167	T=0.833
1000Genomes	Global	Study-wide	5008	C=0.248	T=0.752
1000Genomes	South Asian	Sub	978	C=0.150	T=0.850
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.158	T=0.842
The Genome Aggregation Database	African	Sub	8724	C=0.136	T=0.864
The Genome Aggregation Database	American	Sub	836	C=0.370	T=0.630
The Genome Aggregation Database	East Asian	Sub	1612	C=0.461	T=0.539
The Genome Aggregation Database	Europe	Sub	18484	C=0.166	T=0.833
The Genome Aggregation Database	Global	Study-wide	29958	C=0.179	T=0.820
The Genome Aggregation Database	Other	Sub	302	C=0.170	T=0.830
Trans-Omics for Precision Medicine	Global	Study-wide	29118	C=0.169	T=0.830
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.154	T=0.846

PMID	Title	Author	Journal
22377092	ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.	Wang KS	Drug Alcohol Depend

P-Value

SNP ID	p-value	Traits	Study
rs7192628	5.83E-06	nicotine dependence (smoking)	22377092

eQTL of rs7192628 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs7192628 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr16	87468266	87468306	E067	-26552
chr16	87468827	87468877	E067	-25981
chr16	87468933	87470319	E067	-24539
chr16	87470375	87470601	E067	-24257
chr16	87494647	87494702	E067	-156
chr16	87494728	87494891	E067	0
chr16	87494927	87495666	E067	69
chr16	87496707	87496808	E067	1849
chr16	87496885	87496935	E067	2027
chr16	87497015	87497069	E067	2157
chr16	87497357	87499382	E067	2499
chr16	87499503	87499877	E067	4645
chr16	87499913	87500113	E067	5055
chr16	87500224	87500472	E067	5366
chr16	87500504	87500620	E067	5646
chr16	87503405	87503556	E067	8547
chr16	87503940	87504017	E067	9082
chr16	87504028	87504110	E067	9170
chr16	87504114	87504232	E067	9256
chr16	87504294	87504388	E067	9436
chr16	87504855	87505216	E067	9997
chr16	87505233	87505591	E067	10375
chr16	87505701	87505786	E067	10843
chr16	87505965	87506043	E067	11107
chr16	87509312	87509634	E067	14454
chr16	87509648	87509725	E067	14790
chr16	87509735	87509872	E067	14877
chr16	87510929	87511529	E067	16071
chr16	87514546	87514606	E067	19688
chr16	87514649	87514699	E067	19791
chr16	87518629	87518708	E067	23771
chr16	87519327	87519367	E067	24469
chr16	87519424	87519590	E067	24566
chr16	87519645	87519742	E067	24787
chr16	87519790	87519831	E067	24932
chr16	87519959	87520035	E067	25101
chr16	87520047	87520148	E067	25189
chr16	87520334	87520459	E067	25476
chr16	87520489	87520775	E067	25631
chr16	87457706	87457756	E068	-37102
chr16	87458001	87458072	E068	-36786
chr16	87458074	87458218	E068	-36640
chr16	87458225	87458357	E068	-36501
chr16	87458387	87458437	E068	-36421
chr16	87458460	87458511	E068	-36347
chr16	87468827	87468877	E068	-25981
chr16	87468933	87470319	E068	-24539
chr16	87470375	87470601	E068	-24257
chr16	87494927	87495666	E068	69
chr16	87497357	87499382	E068	2499
chr16	87499503	87499877	E068	4645
chr16	87499913	87500113	E068	5055
chr16	87502280	87502410	E068	7422
chr16	87502481	87502597	E068	7623
chr16	87502851	87502999	E068	7993
chr16	87503405	87503556	E068	8547
chr16	87504855	87505216	E068	9997
chr16	87505233	87505591	E068	10375
chr16	87505701	87505786	E068	10843
chr16	87505965	87506043	E068	11107
chr16	87506230	87506290	E068	11372
chr16	87509312	87509634	E068	14454
chr16	87509648	87509725	E068	14790
chr16	87509735	87509872	E068	14877
chr16	87510394	87510476	E068	15536
chr16	87510669	87510752	E068	15811
chr16	87510847	87510902	E068	15989
chr16	87510929	87511529	E068	16071
chr16	87511809	87511880	E068	16951
chr16	87514546	87514606	E068	19688
chr16	87514649	87514699	E068	19791
chr16	87514778	87514822	E068	19920
chr16	87517959	87518365	E068	23101
chr16	87518370	87518589	E068	23512
chr16	87518629	87518708	E068	23771
chr16	87518730	87518848	E068	23872
chr16	87519327	87519367	E068	24469
chr16	87519424	87519590	E068	24566
chr16	87519645	87519742	E068	24787
chr16	87519790	87519831	E068	24932
chr16	87519959	87520035	E068	25101
chr16	87520047	87520148	E068	25189
chr16	87520334	87520459	E068	25476
chr16	87521726	87521803	E068	26868
chr16	87521934	87521997	E068	27076
chr16	87522037	87522097	E068	27179
chr16	87540977	87541773	E068	46119
chr16	87458001	87458072	E069	-36786
chr16	87458074	87458218	E069	-36640
chr16	87458225	87458357	E069	-36501
chr16	87458387	87458437	E069	-36421
chr16	87460495	87460644	E069	-34214
chr16	87460656	87460759	E069	-34099
chr16	87460849	87461000	E069	-33858
chr16	87467380	87467445	E069	-27413
chr16	87468827	87468877	E069	-25981
chr16	87468933	87470319	E069	-24539
chr16	87470375	87470601	E069	-24257
chr16	87497357	87499382	E069	2499
chr16	87499503	87499877	E069	4645
chr16	87499913	87500113	E069	5055
chr16	87500224	87500472	E069	5366
chr16	87502851	87502999	E069	7993
chr16	87503405	87503556	E069	8547
chr16	87509312	87509634	E069	14454
chr16	87509648	87509725	E069	14790
chr16	87509735	87509872	E069	14877
chr16	87510929	87511529	E069	16071
chr16	87519424	87519590	E069	24566
chr16	87519645	87519742	E069	24787
chr16	87519790	87519831	E069	24932
chr16	87519959	87520035	E069	25101
chr16	87520047	87520148	E069	25189
chr16	87520334	87520459	E069	25476
chr16	87520489	87520775	E069	25631
chr16	87540385	87540456	E069	45527
chr16	87540482	87540596	E069	45624
chr16	87540739	87540950	E069	45881
chr16	87540977	87541773	E069	46119
chr16	87510847	87510902	E070	15989
chr16	87510929	87511529	E070	16071
chr16	87519959	87520035	E070	25101
chr16	87520047	87520148	E070	25189
chr16	87520334	87520459	E070	25476
chr16	87520489	87520775	E070	25631
chr16	87521934	87521997	E070	27076
chr16	87522426	87522486	E070	27568
chr16	87522612	87522874	E070	27754
chr16	87527621	87527759	E070	32763
chr16	87468266	87468306	E071	-26552
chr16	87468827	87468877	E071	-25981
chr16	87468933	87470319	E071	-24539
chr16	87470375	87470601	E071	-24257
chr16	87471042	87471118	E071	-23740
chr16	87494728	87494891	E071	0
chr16	87494927	87495666	E071	69
chr16	87497357	87499382	E071	2499
chr16	87499503	87499877	E071	4645
chr16	87499913	87500113	E071	5055
chr16	87500224	87500472	E071	5366
chr16	87502280	87502410	E071	7422
chr16	87502481	87502597	E071	7623
chr16	87502851	87502999	E071	7993
chr16	87503405	87503556	E071	8547
chr16	87503940	87504017	E071	9082
chr16	87504028	87504110	E071	9170
chr16	87504114	87504232	E071	9256
chr16	87504294	87504388	E071	9436
chr16	87504657	87504701	E071	9799
chr16	87504855	87505216	E071	9997
chr16	87505233	87505591	E071	10375
chr16	87505701	87505786	E071	10843
chr16	87505965	87506043	E071	11107
chr16	87508425	87508831	E071	13567
chr16	87509312	87509634	E071	14454
chr16	87509648	87509725	E071	14790
chr16	87509735	87509872	E071	14877
chr16	87510394	87510476	E071	15536
chr16	87510669	87510752	E071	15811
chr16	87510847	87510902	E071	15989
chr16	87514546	87514606	E071	19688
chr16	87514649	87514699	E071	19791
chr16	87514778	87514822	E071	19920
chr16	87514909	87514982	E071	20051
chr16	87517959	87518365	E071	23101
chr16	87518370	87518589	E071	23512
chr16	87519424	87519590	E071	24566
chr16	87519645	87519742	E071	24787
chr16	87519790	87519831	E071	24932
chr16	87519959	87520035	E071	25101
chr16	87520047	87520148	E071	25189
chr16	87520334	87520459	E071	25476
chr16	87520489	87520775	E071	25631
chr16	87521726	87521803	E071	26868
chr16	87521934	87521997	E071	27076
chr16	87522037	87522097	E071	27179
chr16	87522269	87522309	E071	27411
chr16	87522426	87522486	E071	27568
chr16	87522612	87522874	E071	27754
chr16	87540977	87541773	E071	46119
chr16	87542047	87542101	E071	47189
chr16	87446000	87446054	E072	-48804
chr16	87446106	87446165	E072	-48693
chr16	87446371	87446443	E072	-48415
chr16	87468266	87468306	E072	-26552
chr16	87468827	87468877	E072	-25981
chr16	87468933	87470319	E072	-24539
chr16	87494647	87494702	E072	-156
chr16	87494728	87494891	E072	0
chr16	87494927	87495666	E072	69
chr16	87497357	87499382	E072	2499
chr16	87499503	87499877	E072	4645
chr16	87499913	87500113	E072	5055
chr16	87500224	87500472	E072	5366
chr16	87500504	87500620	E072	5646
chr16	87500832	87501102	E072	5974
chr16	87501125	87501169	E072	6267
chr16	87502851	87502999	E072	7993
chr16	87503405	87503556	E072	8547
chr16	87503940	87504017	E072	9082
chr16	87504028	87504110	E072	9170
chr16	87509312	87509634	E072	14454
chr16	87509648	87509725	E072	14790
chr16	87509735	87509872	E072	14877
chr16	87510394	87510476	E072	15536
chr16	87510669	87510752	E072	15811
chr16	87510847	87510902	E072	15989
chr16	87510929	87511529	E072	16071
chr16	87514546	87514606	E072	19688
chr16	87514649	87514699	E072	19791
chr16	87514778	87514822	E072	19920
chr16	87519645	87519742	E072	24787
chr16	87519790	87519831	E072	24932
chr16	87519959	87520035	E072	25101
chr16	87520047	87520148	E072	25189
chr16	87520334	87520459	E072	25476
chr16	87520489	87520775	E072	25631
chr16	87540977	87541773	E072	46119
chr16	87445064	87445204	E073	-49654
chr16	87445316	87445366	E073	-49492
chr16	87445699	87445755	E073	-49103
chr16	87445797	87445855	E073	-49003
chr16	87446000	87446054	E073	-48804
chr16	87446106	87446165	E073	-48693
chr16	87458001	87458072	E073	-36786
chr16	87458074	87458218	E073	-36640
chr16	87458225	87458357	E073	-36501
chr16	87458387	87458437	E073	-36421
chr16	87458460	87458511	E073	-36347
chr16	87458776	87458826	E073	-36032
chr16	87460194	87460331	E073	-34527
chr16	87465154	87466019	E073	-28839
chr16	87466122	87466210	E073	-28648
chr16	87468266	87468306	E073	-26552
chr16	87468827	87468877	E073	-25981
chr16	87468933	87470319	E073	-24539
chr16	87470375	87470601	E073	-24257
chr16	87494647	87494702	E073	-156
chr16	87494728	87494891	E073	0
chr16	87494927	87495666	E073	69
chr16	87496707	87496808	E073	1849
chr16	87496885	87496935	E073	2027
chr16	87497015	87497069	E073	2157
chr16	87497357	87499382	E073	2499
chr16	87499503	87499877	E073	4645
chr16	87499913	87500113	E073	5055
chr16	87500224	87500472	E073	5366
chr16	87500504	87500620	E073	5646
chr16	87502280	87502410	E073	7422
chr16	87502481	87502597	E073	7623
chr16	87502851	87502999	E073	7993
chr16	87503405	87503556	E073	8547
chr16	87503940	87504017	E073	9082
chr16	87504028	87504110	E073	9170
chr16	87504114	87504232	E073	9256
chr16	87505233	87505591	E073	10375
chr16	87509312	87509634	E073	14454
chr16	87509648	87509725	E073	14790
chr16	87509735	87509872	E073	14877
chr16	87510394	87510476	E073	15536
chr16	87510669	87510752	E073	15811
chr16	87510847	87510902	E073	15989
chr16	87510929	87511529	E073	16071
chr16	87517844	87517898	E073	22986
chr16	87517959	87518365	E073	23101
chr16	87518370	87518589	E073	23512
chr16	87518629	87518708	E073	23771
chr16	87518730	87518848	E073	23872
chr16	87519327	87519367	E073	24469
chr16	87519424	87519590	E073	24566
chr16	87519645	87519742	E073	24787
chr16	87519790	87519831	E073	24932
chr16	87519959	87520035	E073	25101
chr16	87521726	87521803	E073	26868
chr16	87521934	87521997	E073	27076
chr16	87522037	87522097	E073	27179
chr16	87522269	87522309	E073	27411
chr16	87522426	87522486	E073	27568
chr16	87522612	87522874	E073	27754
chr16	87540385	87540456	E073	45527
chr16	87540482	87540596	E073	45624
chr16	87540739	87540950	E073	45881
chr16	87540977	87541773	E073	46119
chr16	87468827	87468877	E074	-25981
chr16	87468933	87470319	E074	-24539
chr16	87470375	87470601	E074	-24257
chr16	87497357	87499382	E074	2499
chr16	87499503	87499877	E074	4645
chr16	87499913	87500113	E074	5055
chr16	87500224	87500472	E074	5366
chr16	87500504	87500620	E074	5646
chr16	87509312	87509634	E074	14454
chr16	87509648	87509725	E074	14790
chr16	87509735	87509872	E074	14877
chr16	87510394	87510476	E074	15536
chr16	87510669	87510752	E074	15811
chr16	87510847	87510902	E074	15989
chr16	87510929	87511529	E074	16071
chr16	87517959	87518365	E074	23101
chr16	87518370	87518589	E074	23512
chr16	87519424	87519590	E074	24566
chr16	87519645	87519742	E074	24787
chr16	87519790	87519831	E074	24932
chr16	87519959	87520035	E074	25101
chr16	87520047	87520148	E074	25189
chr16	87520334	87520459	E074	25476
chr16	87520489	87520775	E074	25631
chr16	87521726	87521803	E074	26868
chr16	87521934	87521997	E074	27076
chr16	87522037	87522097	E074	27179
chr16	87522269	87522309	E074	27411
chr16	87522426	87522486	E074	27568
chr16	87522612	87522874	E074	27754
chr16	87540005	87540316	E074	45147
chr16	87540385	87540456	E074	45527
chr16	87540482	87540596	E074	45624
chr16	87540739	87540950	E074	45881
chr16	87540977	87541773	E074	46119
chr16	87488365	87488415	E081	-6443
chr16	87488467	87488511	E081	-6347
chr16	87488990	87489040	E081	-5818
chr16	87509312	87509634	E081	14454
chr16	87509648	87509725	E081	14790
chr16	87509735	87509872	E081	14877
chr16	87510394	87510476	E081	15536
chr16	87510669	87510752	E081	15811
chr16	87510847	87510902	E081	15989
chr16	87510929	87511529	E081	16071
chr16	87515818	87516128	E081	20960
chr16	87516744	87516784	E081	21886
chr16	87517197	87517475	E081	22339
chr16	87517673	87517723	E081	22815
chr16	87517844	87517898	E081	22986
chr16	87517959	87518365	E081	23101
chr16	87518370	87518589	E081	23512
chr16	87518629	87518708	E081	23771
chr16	87518730	87518848	E081	23872
chr16	87519327	87519367	E081	24469
chr16	87519424	87519590	E081	24566
chr16	87519645	87519742	E081	24787
chr16	87519790	87519831	E081	24932
chr16	87519959	87520035	E081	25101
chr16	87520047	87520148	E081	25189
chr16	87520334	87520459	E081	25476
chr16	87520489	87520775	E081	25631
chr16	87521726	87521803	E081	26868
chr16	87521934	87521997	E081	27076
chr16	87522037	87522097	E081	27179
chr16	87522269	87522309	E081	27411
chr16	87522426	87522486	E081	27568
chr16	87522612	87522874	E081	27754
chr16	87527621	87527759	E081	32763
chr16	87489373	87489868	E082	-4990
chr16	87519645	87519742	E082	24787
chr16	87519790	87519831	E082	24932
chr16	87519959	87520035	E082	25101
chr16	87520047	87520148	E082	25189

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr16	87523945	87524785	E067	29087
chr16	87525319	87525586	E067	30461
chr16	87525676	87525886	E067	30818
chr16	87526297	87527176	E067	31439
chr16	87523945	87524785	E068	29087
chr16	87525319	87525586	E068	30461
chr16	87525676	87525886	E068	30818
chr16	87523945	87524785	E069	29087
chr16	87525319	87525586	E069	30461
chr16	87525676	87525886	E069	30818
chr16	87525972	87526113	E069	31114
chr16	87526115	87526170	E069	31257
chr16	87526171	87526248	E069	31313
chr16	87526297	87527176	E069	31439
chr16	87523945	87524785	E070	29087
chr16	87525319	87525586	E070	30461
chr16	87525676	87525886	E070	30818
chr16	87525972	87526113	E070	31114
chr16	87526115	87526170	E070	31257
chr16	87526171	87526248	E070	31313
chr16	87526297	87527176	E070	31439
chr16	87523945	87524785	E071	29087
chr16	87525319	87525586	E071	30461
chr16	87525676	87525886	E071	30818
chr16	87523945	87524785	E072	29087
chr16	87525319	87525586	E072	30461
chr16	87525676	87525886	E072	30818
chr16	87525972	87526113	E072	31114
chr16	87526115	87526170	E072	31257
chr16	87526171	87526248	E072	31313
chr16	87526297	87527176	E072	31439
chr16	87523945	87524785	E073	29087
chr16	87525319	87525586	E073	30461
chr16	87525676	87525886	E073	30818
chr16	87523945	87524785	E074	29087
chr16	87525319	87525586	E074	30461
chr16	87525676	87525886	E074	30818
chr16	87536008	87536048	E081	41150
chr16	87523945	87524785	E082	29087
chr16	87525319	87525586	E082	30461
chr16	87525676	87525886	E082	30818
chr16	87525972	87526113	E082	31114
chr16	87526115	87526170	E082	31257
chr16	87526171	87526248	E082	31313
chr16	87526297	87527176	E082	31439