rs7228438

Homo sapiens
G>T
ZNF407 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0336 (10059/29878,GnomAD)
G==0410 (11941/29118,TOPMED)
G==0321 (1610/5008,1000G)
G==0298 (1148/3854,ALSPAC)
G==0280 (1038/3708,TWINSUK)
chr18:74781358 (GRCh38.p7) (18q22.3)
AD
GWASdb2
1   publication(s)
See rs on genome
22 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.74781358G>T
GRCh37.p13 chr 18NC_000018.9:g.72493314G>T
ZNF407 RefSeqGeneNG_013216.1:g.155396G>T

Gene: ZNF407, zinc finger protein 407(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ZNF407 transcript variant 2NM_001146189.1:c.N/AIntron Variant
ZNF407 transcript variant 3NM_001146190.1:c.N/AIntron Variant
ZNF407 transcript variant 1NM_017757.2:c.N/AIntron Variant
ZNF407 transcript variant X2XM_005266726.4:c.N/AIntron Variant
ZNF407 transcript variant X6XM_006722500.3:c.N/AIntron Variant
ZNF407 transcript variant X2XM_011526068.2:c.N/AIntron Variant
ZNF407 transcript variant X4XM_011526069.2:c.N/AIntron Variant
ZNF407 transcript variant X5XM_011526070.1:c.N/AIntron Variant
ZNF407 transcript variant X3XM_017025838.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.611T=0.389
1000GenomesAmericanSub694G=0.200T=0.800
1000GenomesEast AsianSub1008G=0.052T=0.948
1000GenomesEuropeSub1006G=0.289T=0.711
1000GenomesGlobalStudy-wide5008G=0.321T=0.679
1000GenomesSouth AsianSub978G=0.330T=0.670
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.298T=0.702
The Genome Aggregation DatabaseAfricanSub8696G=0.563T=0.437
The Genome Aggregation DatabaseAmericanSub838G=0.160T=0.840
The Genome Aggregation DatabaseEast AsianSub1614G=0.055T=0.945
The Genome Aggregation DatabaseEuropeSub18430G=0.265T=0.734
The Genome Aggregation DatabaseGlobalStudy-wide29878G=0.336T=0.663
The Genome Aggregation DatabaseOtherSub300G=0.170T=0.830
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.410T=0.589
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.280T=0.720
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs72284389.25E-06alcohol dependence (age at onset)24962325

eQTL of rs7228438 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7228438 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr187250958272509739E06816268
chr187250883572509567E06915521
chr187250958272509739E06916268
chr187249227872492328E070-986
chr187249775072497820E0704436
chr187250843972508756E07015125
chr187250883572509567E07015521
chr187250958272509739E07016268
chr187250982072510344E07016506
chr187253957172539621E07046257
chr187254018072540243E07046866
chr187254029772540398E07046983
chr187250764372508030E08114329
chr187250831572508373E08115001
chr187250843972508756E08115125
chr187250883572509567E08115521
chr187250958272509739E08116268
chr187250764372508030E08214329
chr187250831572508373E08215001
chr187250843972508756E08215125
chr187250883572509567E08215521
chr187250958272509739E08216268