rs7229235

Homo sapiens
G>A
ZNF407 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0353 (10564/29930,GnomAD)
G==0437 (12743/29118,TOPMED)
G==0340 (1702/5008,1000G)
G==0299 (1151/3854,ALSPAC)
G==0280 (1040/3708,TWINSUK)
chr18:74783036 (GRCh38.p7) (18q22.3)
AD
GWASdb2
1   publication(s)
See rs on genome
22 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.74783036G>A
GRCh37.p13 chr 18NC_000018.9:g.72494992G>A
ZNF407 RefSeqGeneNG_013216.1:g.157074G>A

Gene: ZNF407, zinc finger protein 407(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ZNF407 transcript variant 2NM_001146189.1:c.N/AIntron Variant
ZNF407 transcript variant 3NM_001146190.1:c.N/AIntron Variant
ZNF407 transcript variant 1NM_017757.2:c.N/AIntron Variant
ZNF407 transcript variant X2XM_005266726.4:c.N/AIntron Variant
ZNF407 transcript variant X2XM_011526068.2:c.N/AIntron Variant
ZNF407 transcript variant X4XM_011526069.2:c.N/AIntron Variant
ZNF407 transcript variant X5XM_011526070.1:c.N/AIntron Variant
ZNF407 transcript variant X3XM_017025838.1:c.N/AIntron Variant
ZNF407 transcript variant X6XM_006722500.3:c.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.673A=0.327
1000GenomesAmericanSub694G=0.220A=0.780
1000GenomesEast AsianSub1008G=0.052A=0.948
1000GenomesEuropeSub1006G=0.290A=0.710
1000GenomesGlobalStudy-wide5008G=0.340A=0.660
1000GenomesSouth AsianSub978G=0.330A=0.670
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.299A=0.701
The Genome Aggregation DatabaseAfricanSub8690G=0.618A=0.382
The Genome Aggregation DatabaseAmericanSub836G=0.170A=0.830
The Genome Aggregation DatabaseEast AsianSub1622G=0.054A=0.946
The Genome Aggregation DatabaseEuropeSub18480G=0.266A=0.734
The Genome Aggregation DatabaseGlobalStudy-wide29930G=0.353A=0.647
The Genome Aggregation DatabaseOtherSub302G=0.170A=0.830
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.437A=0.562
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.280A=0.720
PMID Title Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.Kapoor MDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs72292359.65E-06alcohol dependence (age at onset)24962325

eQTL of rs7229235 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7229235 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr187250958272509739E06814590
chr187250883572509567E06913843
chr187250958272509739E06914590
chr187249227872492328E070-2664
chr187249775072497820E0702758
chr187250843972508756E07013447
chr187250883572509567E07013843
chr187250958272509739E07014590
chr187250982072510344E07014828
chr187253957172539621E07044579
chr187254018072540243E07045188
chr187254029772540398E07045305
chr187250764372508030E08112651
chr187250831572508373E08113323
chr187250843972508756E08113447
chr187250883572509567E08113843
chr187250958272509739E08114590
chr187250764372508030E08212651
chr187250831572508373E08213323
chr187250843972508756E08213447
chr187250883572509567E08213843
chr187250958272509739E08214590