rs7235367

Homo sapiens
G>A
PHLPP1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0321 (9630/29944,GnomAD)
A=0326 (9520/29118,TOPMED)
A=0437 (2188/5008,1000G)
A=0289 (1115/3854,ALSPAC)
A=0298 (1104/3708,TWINSUK)
chr18:62942490 (GRCh38.p7) (18q21.33)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.62942490G>A
GRCh37.p13 chr 18NC_000018.9:g.60609723G>A
PHLPP1 RefSeqGeneNG_031923.1:g.232052G>A

Gene: PHLPP1, PH domain and leucine rich repeat protein phosphatase 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
PHLPP1 transcriptNM_194449.3:c.N/AIntron Variant
PHLPP1 transcript variant X2XM_011525886.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.662A=0.338
1000GenomesAmericanSub694G=0.590A=0.410
1000GenomesEast AsianSub1008G=0.363A=0.637
1000GenomesEuropeSub1006G=0.700A=0.300
1000GenomesGlobalStudy-wide5008G=0.563A=0.437
1000GenomesSouth AsianSub978G=0.480A=0.520
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.711A=0.289
The Genome Aggregation DatabaseAfricanSub8714G=0.670A=0.330
The Genome Aggregation DatabaseAmericanSub832G=0.580A=0.420
The Genome Aggregation DatabaseEast AsianSub1612G=0.355A=0.645
The Genome Aggregation DatabaseEuropeSub18484G=0.713A=0.286
The Genome Aggregation DatabaseGlobalStudy-wide29944G=0.678A=0.321
The Genome Aggregation DatabaseOtherSub302G=0.770A=0.230
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.673A=0.326
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.702A=0.298
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs72353670.00083alcohol dependence20201924

eQTL of rs7235367 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7235367 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr186056140660561499E067-48224
chr186056172560561780E067-47943
chr186056185960561942E067-47781
chr186056199660562157E067-47566
chr186056223860562543E067-47180
chr186056387760563959E067-45764
chr186057135860571608E067-38115
chr186057167660571726E067-37997
chr186057177560572549E067-37174
chr186058571760585872E067-23851
chr186058612960586169E067-23554
chr186058639360586733E067-22990
chr186058677360586990E067-22733
chr186058707760587137E067-22586
chr186058729760587341E067-22382
chr186060420460604394E067-5329
chr186060443360604580E067-5143
chr186060668360607081E067-2642
chr186060717660607524E067-2199
chr186060985160610131E067128
chr186061314860613188E0673425
chr186061698860617055E0677265
chr186061722760617289E0677504
chr186061766160617714E0677938
chr186061774660617831E0678023
chr186061787760617974E0678154
chr186061797760618040E0678254
chr186061806660618151E0678343
chr186062062660620714E06710903
chr186062082360621303E06711100
chr186062141160621477E06711688
chr186062167260621841E06711949
chr186062202760622091E06712304
chr186062223760622323E06712514
chr186062241660622553E06712693
chr186063028660630406E06720563
chr186063040960630696E06720686
chr186063073660631075E06721013
chr186063107660631402E06721353
chr186063176760631993E06722044
chr186063244460632636E06722721
chr186063824460638364E06728521
chr186063841960638613E06728696
chr186063878560638835E06729062
chr186063952660639655E06729803
chr186063972160639781E06729998
chr186063987760639990E06730154
chr186064004860640100E06730325
chr186064046460640525E06730741
chr186064060360641095E06730880
chr186064160360641685E06731880
chr186064186260641916E06732139
chr186064242760642835E06732704
chr186064316860643218E06733445
chr186064339260643442E06733669
chr186064351960643830E06733796
chr186064412960644179E06734406
chr186064512960645169E06735406
chr186064520360645305E06735480
chr186064549860645585E06735775
chr186064566660645716E06735943
chr186064589960645949E06736176
chr186064603360646156E06736310
chr186064615860646208E06736435
chr186064632960646418E06736606
chr186064651460646816E06736791
chr186064724460647415E06737521
chr186064746360647584E06737740
chr186064767560647769E06737952
chr186064822660648312E06738503
chr186064925960649402E06739536
chr186064941360649482E06739690
chr186064952360649573E06739800
chr186064960460649745E06739881
chr186064975960650331E06740036
chr186065038560650481E06740662
chr186065357160653621E06743848
chr186065390760654016E06744184
chr186065404460654117E06744321
chr186065417060654238E06744447
chr186065431460654366E06744591
chr186065443260654539E06744709
chr186065560160655651E06745878
chr186065584260655969E06746119
chr186065622560656336E06746502
chr186065648560656592E06746762
chr186065663560656690E06746912
chr186065673160656785E06747008
chr186065681460656905E06747091
chr186056082060560979E068-48744
chr186056103860561198E068-48525
chr186056121160561302E068-48421
chr186056140660561499E068-48224
chr186056172560561780E068-47943
chr186056185960561942E068-47781
chr186056199660562157E068-47566
chr186056979760570022E068-39701
chr186057003660570467E068-39256
chr186057135860571608E068-38115
chr186057167660571726E068-37997
chr186057177560572549E068-37174
chr186058571760585872E068-23851
chr186058612960586169E068-23554
chr186058639360586733E068-22990
chr186058677360586990E068-22733
chr186058707760587137E068-22586
chr186058729760587341E068-22382
chr186060524860605744E068-3979
chr186060580560606166E068-3557
chr186060651560606555E068-3168
chr186060668360607081E068-2642
chr186060717660607524E068-2199
chr186060806960608119E068-1604
chr186060820760608277E068-1446
chr186061017660610448E068453
chr186061438360614433E0684660
chr186061698860617055E0687265
chr186061722760617289E0687504
chr186061766160617714E0687938
chr186061774660617831E0688023
chr186061787760617974E0688154
chr186061797760618040E0688254
chr186062082360621303E06811100
chr186062141160621477E06811688
chr186062167260621841E06811949
chr186062202760622091E06812304
chr186062223760622323E06812514
chr186062241660622553E06812693
chr186063028660630406E06820563
chr186063040960630696E06820686
chr186063073660631075E06821013
chr186063107660631402E06821353
chr186063176760631993E06822044
chr186063244460632636E06822721
chr186063806360638120E06828340
chr186063824460638364E06828521
chr186063841960638613E06828696
chr186063878560638835E06829062
chr186063952660639655E06829803
chr186063972160639781E06829998
chr186063987760639990E06830154
chr186064004860640100E06830325
chr186064046460640525E06830741
chr186064060360641095E06830880
chr186064160360641685E06831880
chr186064186260641916E06832139
chr186064242760642835E06832704
chr186064316860643218E06833445
chr186064339260643442E06833669
chr186064351960643830E06833796
chr186064412960644179E06834406
chr186064445160644495E06834728
chr186064474860645041E06835025
chr186064512960645169E06835406
chr186064520360645305E06835480
chr186064549860645585E06835775
chr186064566660645716E06835943
chr186064589960645949E06836176
chr186064603360646156E06836310
chr186064615860646208E06836435
chr186064632960646418E06836606
chr186064651460646816E06836791
chr186064724460647415E06837521
chr186064746360647584E06837740
chr186064767560647769E06837952
chr186064925960649402E06839536
chr186064941360649482E06839690
chr186064952360649573E06839800
chr186064975960650331E06840036
chr186065038560650481E06840662
chr186065221460652314E06842491
chr186065250360652553E06842780
chr186065417060654238E06844447
chr186065431460654366E06844591
chr186065443260654539E06844709
chr186065478860654857E06845065
chr186065492760655018E06845204
chr186065584260655969E06846119
chr186065622560656336E06846502
chr186056103860561198E069-48525
chr186056121160561302E069-48421
chr186056962060569670E069-40053
chr186056979760570022E069-39701
chr186057003660570467E069-39256
chr186057135860571608E069-38115
chr186057167660571726E069-37997
chr186057177560572549E069-37174
chr186057322060573387E069-36336
chr186058172160581809E069-27914
chr186058213760582187E069-27536
chr186058612960586169E069-23554
chr186058639360586733E069-22990
chr186058677360586990E069-22733
chr186058707760587137E069-22586
chr186058729760587341E069-22382
chr186059346060593539E069-16184
chr186059378060593830E069-15893
chr186060386160603918E069-5805
chr186060412960604194E069-5529
chr186060420460604394E069-5329
chr186060443360604580E069-5143
chr186060460560604708E069-5015
chr186060476260604872E069-4851
chr186060524860605744E069-3979
chr186060580560606166E069-3557
chr186060985160610131E069128
chr186061017660610448E069453
chr186061075060610846E0691027
chr186061241360612463E0692690
chr186061698860617055E0697265
chr186061722760617289E0697504
chr186061766160617714E0697938
chr186061774660617831E0698023
chr186061787760617974E0698154
chr186062062660620714E06910903
chr186062082360621303E06911100
chr186062141160621477E06911688
chr186062167260621841E06911949
chr186062202760622091E06912304
chr186062223760622323E06912514
chr186062241660622553E06912693
chr186062280460622884E06913081
chr186063028660630406E06920563
chr186063040960630696E06920686
chr186063073660631075E06921013
chr186063107660631402E06921353
chr186063176760631993E06922044
chr186063244460632636E06922721
chr186063824460638364E06928521
chr186063841960638613E06928696
chr186063878560638835E06929062
chr186063952660639655E06929803
chr186063972160639781E06929998
chr186063987760639990E06930154
chr186064004860640100E06930325
chr186064046460640525E06930741
chr186064060360641095E06930880
chr186064160360641685E06931880
chr186064186260641916E06932139
chr186064242760642835E06932704
chr186064316860643218E06933445
chr186064339260643442E06933669
chr186064351960643830E06933796
chr186064412960644179E06934406
chr186064445160644495E06934728
chr186064474860645041E06935025
chr186064512960645169E06935406
chr186064520360645305E06935480
chr186064549860645585E06935775
chr186064566660645716E06935943
chr186064589960645949E06936176
chr186064603360646156E06936310
chr186064615860646208E06936435
chr186064632960646418E06936606
chr186064651460646816E06936791
chr186064724460647415E06937521
chr186064746360647584E06937740
chr186064767560647769E06937952
chr186064822660648312E06938503
chr186064925960649402E06939536
chr186064941360649482E06939690
chr186064952360649573E06939800
chr186064960460649745E06939881
chr186064975960650331E06940036
chr186065038560650481E06940662
chr186065390760654016E06944184
chr186065404460654117E06944321
chr186065417060654238E06944447
chr186065431460654366E06944591
chr186065443260654539E06944709
chr186065478860654857E06945065
chr186065492760655018E06945204
chr186065519260655323E06945469
chr186065543060655548E06945707
chr186065560160655651E06945878
chr186063040960630696E07020686
chr186063073660631075E07021013
chr186063107660631402E07021353
chr186064566660645716E07035943
chr186064589960645949E07036176
chr186064603360646156E07036310
chr186064615860646208E07036435
chr186064632960646418E07036606
chr186064651460646816E07036791
chr186064724460647415E07037521
chr186064746360647584E07037740
chr186064960460649745E07039881
chr186064975960650331E07040036
chr186056082060560979E071-48744
chr186056103860561198E071-48525
chr186056121160561302E071-48421
chr186056140660561499E071-48224
chr186056172560561780E071-47943
chr186056185960561942E071-47781
chr186056199660562157E071-47566
chr186056845560568738E071-40985
chr186056962060569670E071-40053
chr186056979760570022E071-39701
chr186057003660570467E071-39256
chr186057135860571608E071-38115
chr186057167660571726E071-37997
chr186057177560572549E071-37174
chr186057322060573387E071-36336
chr186058213760582187E071-27536
chr186058571760585872E071-23851
chr186058612960586169E071-23554
chr186058639360586733E071-22990
chr186058677360586990E071-22733
chr186058707760587137E071-22586
chr186058729760587341E071-22382
chr186059237660592984E071-16739
chr186059346060593539E071-16184
chr186060386160603918E071-5805
chr186060412960604194E071-5529
chr186060420460604394E071-5329
chr186060443360604580E071-5143
chr186060460560604708E071-5015
chr186060476260604872E071-4851
chr186060524860605744E071-3979
chr186060580560606166E071-3557
chr186060651560606555E071-3168
chr186060668360607081E071-2642
chr186060717660607524E071-2199
chr186060806960608119E071-1604
chr186060985160610131E071128
chr186061017660610448E071453
chr186061075060610846E0711027
chr186061178460612037E0712061
chr186061698860617055E0717265
chr186061722760617289E0717504
chr186061766160617714E0717938
chr186061774660617831E0718023
chr186061787760617974E0718154
chr186061797760618040E0718254
chr186061806660618151E0718343
chr186062062660620714E07110903
chr186062082360621303E07111100
chr186062141160621477E07111688
chr186062167260621841E07111949
chr186062202760622091E07112304
chr186062223760622323E07112514
chr186062241660622553E07112693
chr186062426260624409E07114539
chr186062461060624660E07114887
chr186063028660630406E07120563
chr186063040960630696E07120686
chr186063073660631075E07121013
chr186063107660631402E07121353
chr186063176760631993E07122044
chr186063244460632636E07122721
chr186063328260633370E07123559
chr186063806360638120E07128340
chr186063824460638364E07128521
chr186063841960638613E07128696
chr186063878560638835E07129062
chr186063952660639655E07129803
chr186063972160639781E07129998
chr186063987760639990E07130154
chr186064004860640100E07130325
chr186064046460640525E07130741
chr186064060360641095E07130880
chr186064160360641685E07131880
chr186064186260641916E07132139
chr186064242760642835E07132704
chr186064316860643218E07133445
chr186064339260643442E07133669
chr186064351960643830E07133796
chr186064412960644179E07134406
chr186064445160644495E07134728
chr186064474860645041E07135025
chr186064512960645169E07135406
chr186064520360645305E07135480
chr186064549860645585E07135775
chr186064566660645716E07135943
chr186064615860646208E07136435
chr186064632960646418E07136606
chr186064651460646816E07136791
chr186064822660648312E07138503
chr186064925960649402E07139536
chr186064941360649482E07139690
chr186064952360649573E07139800
chr186064960460649745E07139881
chr186064975960650331E07140036
chr186065038560650481E07140662
chr186065197560652025E07142252
chr186065208360652133E07142360
chr186065221460652314E07142491
chr186065250360652553E07142780
chr186065288960652929E07143166
chr186065357160653621E07143848
chr186065390760654016E07144184
chr186065404460654117E07144321
chr186065417060654238E07144447
chr186065431460654366E07144591
chr186065443260654539E07144709
chr186065478860654857E07145065
chr186065492760655018E07145204
chr186065519260655323E07145469
chr186065543060655548E07145707
chr186065560160655651E07145878
chr186065622560656336E07146502
chr186065648560656592E07146762
chr186065663560656690E07146912
chr186065673160656785E07147008
chr186065681460656905E07147091
chr186056103860561198E072-48525
chr186056121160561302E072-48421
chr186056140660561499E072-48224
chr186056172560561780E072-47943
chr186056185960561942E072-47781
chr186056199660562157E072-47566
chr186056223860562543E072-47180
chr186056962060569670E072-40053
chr186056979760570022E072-39701
chr186057003660570467E072-39256
chr186057135860571608E072-38115
chr186057167660571726E072-37997
chr186057177560572549E072-37174
chr186058263960582699E072-27024
chr186058280260583056E072-26667
chr186058312360583254E072-26469
chr186058374960583945E072-25778
chr186058448060584836E072-24887
chr186058571760585872E072-23851
chr186058612960586169E072-23554
chr186058639360586733E072-22990
chr186058677360586990E072-22733
chr186058707760587137E072-22586
chr186058729760587341E072-22382
chr186060460560604708E072-5015
chr186060476260604872E072-4851
chr186060524860605744E072-3979
chr186060580560606166E072-3557
chr186060651560606555E072-3168
chr186060668360607081E072-2642
chr186060717660607524E072-2199
chr186060985160610131E072128
chr186061017660610448E072453
chr186061075060610846E0721027
chr186061241360612463E0722690
chr186061314860613188E0723425
chr186061698860617055E0727265
chr186061722760617289E0727504
chr186061766160617714E0727938
chr186062062660620714E07210903
chr186062082360621303E07211100
chr186062141160621477E07211688
chr186062167260621841E07211949
chr186062202760622091E07212304
chr186062223760622323E07212514
chr186062241660622553E07212693
chr186063028660630406E07220563
chr186063040960630696E07220686
chr186063073660631075E07221013
chr186063107660631402E07221353
chr186063176760631993E07222044
chr186063244460632636E07222721
chr186063328260633370E07223559
chr186063841960638613E07228696
chr186063878560638835E07229062
chr186063952660639655E07229803
chr186063972160639781E07229998
chr186063987760639990E07230154
chr186064004860640100E07230325
chr186064046460640525E07230741
chr186064060360641095E07230880
chr186064160360641685E07231880
chr186064186260641916E07232139
chr186064242760642835E07232704
chr186064316860643218E07233445
chr186064339260643442E07233669
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