rs7242186

Homo sapiens
G>A
SOCS6 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0258 (7726/29918,GnomAD)
G==0281 (8203/29118,TOPMED)
G==0214 (1073/5008,1000G)
G==0238 (916/3854,ALSPAC)
G==0242 (899/3708,TWINSUK)
chr18:70314625 (GRCh38.p7) (18q22.2)
AD
GWASdb2
1   publication(s)
See rs on genome
122 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.70314625G>A
GRCh37.p13 chr 18NC_000018.9:g.67981861G>A

Gene: SOCS6, suppressor of cytokine signaling 6(plus strand)

Molecule type Change Amino acid[Codon] SO Term
SOCS6 transcriptNM_004232.3:c.N/AIntron Variant
SOCS6 transcript variant X1XM_005266783.3:c.N/AIntron Variant
SOCS6 transcript variant X2XM_017026086.1:c.N/AIntron Variant
SOCS6 transcript variant X3XM_017026087.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.361A=0.639
1000GenomesAmericanSub694G=0.170A=0.830
1000GenomesEast AsianSub1008G=0.092A=0.908
1000GenomesEuropeSub1006G=0.258A=0.742
1000GenomesGlobalStudy-wide5008G=0.214A=0.786
1000GenomesSouth AsianSub978G=0.120A=0.880
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.238A=0.762
The Genome Aggregation DatabaseAfricanSub8692G=0.324A=0.676
The Genome Aggregation DatabaseAmericanSub838G=0.160A=0.840
The Genome Aggregation DatabaseEast AsianSub1618G=0.071A=0.929
The Genome Aggregation DatabaseEuropeSub18468G=0.249A=0.751
The Genome Aggregation DatabaseGlobalStudy-wide29918G=0.258A=0.741
The Genome Aggregation DatabaseOtherSub302G=0.230A=0.770
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.281A=0.718
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.242A=0.758
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs72421860.00088alcohol dependence20201924

eQTL of rs7242186 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7242186 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr186795827167958377E067-23484
chr186795844267958732E067-23129
chr186795916567959904E067-21957
chr186795997367960199E067-21662
chr186796022067960349E067-21512
chr186796041667960792E067-21069
chr186796180667962235E067-19626
chr186796224567962788E067-19073
chr186796279167962968E067-18893
chr186796300467964236E067-17625
chr186796828567968484E067-13377
chr186796860867968701E067-13160
chr186796876367968813E067-13048
chr186796886967969227E067-12634
chr186797811767978465E067-3396
chr186797848467978617E067-3244
chr186799017267990554E0678311
chr186799965967999735E06717798
chr186795916567959904E068-21957
chr186795997367960199E068-21662
chr186796022067960349E068-21512
chr186796041667960792E068-21069
chr186796180667962235E068-19626
chr186796224567962788E068-19073
chr186796279167962968E068-18893
chr186796431167964458E068-17403
chr186796828567968484E068-13377
chr186796860867968701E068-13160
chr186796876367968813E068-13048
chr186796886967969227E068-12634
chr186796960067969640E068-12221
chr186796970167969937E068-11924
chr186799017267990554E0688311
chr186799876567998931E06816904
chr186799911067999364E06817249
chr186799965967999735E06817798
chr186795827167958377E069-23484
chr186795844267958732E069-23129
chr186795916567959904E069-21957
chr186795997367960199E069-21662
chr186796022067960349E069-21512
chr186796041667960792E069-21069
chr186796180667962235E069-19626
chr186796224567962788E069-19073
chr186796279167962968E069-18893
chr186796300467964236E069-17625
chr186796828567968484E069-13377
chr186796860867968701E069-13160
chr186796876367968813E069-13048
chr186796886967969227E069-12634
chr186796960067969640E069-12221
chr186796970167969937E069-11924
chr186797848467978617E069-3244
chr186799017267990554E0698311
chr186799876567998931E06916904
chr186799911067999364E06917249
chr186799965967999735E06917798
chr186795827167958377E070-23484
chr186796494067965305E070-16556
chr186795997367960199E071-21662
chr186796022067960349E071-21512
chr186796180667962235E071-19626
chr186796224567962788E071-19073
chr186796279167962968E071-18893
chr186796300467964236E071-17625
chr186796431167964458E071-17403
chr186796494067965305E071-16556
chr186796645267966893E071-14968
chr186796828567968484E071-13377
chr186796860867968701E071-13160
chr186796876367968813E071-13048
chr186796886967969227E071-12634
chr186799017267990554E0718311
chr186799098667991180E0719125
chr186799876567998931E07116904
chr186799911067999364E07117249
chr186795827167958377E072-23484
chr186795844267958732E072-23129
chr186796224567962788E072-19073
chr186796300467964236E072-17625
chr186796431167964458E072-17403
chr186796828567968484E072-13377
chr186796860867968701E072-13160
chr186796876367968813E072-13048
chr186796886967969227E072-12634
chr186796960067969640E072-12221
chr186796970167969937E072-11924
chr186799017267990554E0728311
chr186799098667991180E0729125
chr186799828667998369E07216425
chr186799876567998931E07216904
chr186799911067999364E07217249
chr186799965967999735E07217798
chr186795997367960199E073-21662
chr186796300467964236E073-17625
chr186796886967969227E073-12634
chr186799911067999364E07317249
chr186795827167958377E074-23484
chr186795844267958732E074-23129
chr186796022067960349E074-21512
chr186796041667960792E074-21069
chr186796180667962235E074-19626
chr186796224567962788E074-19073
chr186796279167962968E074-18893
chr186796300467964236E074-17625
chr186796431167964458E074-17403
chr186796494067965305E074-16556
chr186796645267966893E074-14968
chr186796828567968484E074-13377
chr186796860867968701E074-13160
chr186796876367968813E074-13048
chr186797790167978059E074-3802
chr186799017267990554E0748311
chr186799098667991180E0749125
chr186799876567998931E07416904
chr186799911067999364E07417249
chr186799965967999735E07417798
chr186799974568000330E07417884
chr186795827167958377E081-23484
chr186795844267958732E081-23129
chr186798893967989139E0817078
chr186799098667991180E0829125










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr186795469167957965E067-23896
chr186795469167957965E068-23896
chr186795469167957965E069-23896
chr186795469167957965E070-23896
chr186795469167957965E071-23896
chr186795469167957965E072-23896
chr186795469167957965E073-23896
chr186795469167957965E074-23896
chr186795469167957965E082-23896