rs7249037

Homo sapiens
G>A
WDR18 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0238 (6948/29118,TOPMED)
A=0252 (6094/24174,GnomAD)
A=0218 (1093/5008,1000G)
A=0179 (690/3854,ALSPAC)
A=0170 (630/3708,TWINSUK)
chr19:988136 (GRCh38.p7) (19p13.3)
AD
GWASdb2
1   publication(s)
See rs on genome
119 Enhancers around
28 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 19NC_000019.10:g.988136G>A
GRCh37.p13 chr 19NC_000019.9:g.988136G>A

Gene: WDR18, WD repeat domain 18(plus strand)

Molecule type Change Amino acid[Codon] SO Term
WDR18 transcriptNM_024100.3:c.N/AIntron Variant
WDR18 transcript variant X1XM_017027027.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.728A=0.272
1000GenomesAmericanSub694G=0.850A=0.150
1000GenomesEast AsianSub1008G=0.748A=0.252
1000GenomesEuropeSub1006G=0.832A=0.168
1000GenomesGlobalStudy-wide5008G=0.782A=0.218
1000GenomesSouth AsianSub978G=0.790A=0.210
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.821A=0.179
The Genome Aggregation DatabaseAfricanSub7736G=0.683A=0.317
The Genome Aggregation DatabaseAmericanSub722G=0.850A=0.150
The Genome Aggregation DatabaseEast AsianSub1508G=0.725A=0.275
The Genome Aggregation DatabaseEuropeSub13958G=0.782A=0.217
The Genome Aggregation DatabaseGlobalStudy-wide24174G=0.747A=0.252
The Genome Aggregation DatabaseOtherSub250G=0.660A=0.340
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.761A=0.238
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.830A=0.170
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs72490370.00086alcohol dependence20201924

eQTL of rs7249037 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7249037 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr19940207940264E067-47872
chr19950706950795E067-37341
chr19983359983479E067-4657
chr19983553983756E067-4380
chr1910156081015844E06727472
chr1910158511016391E06727715
chr1910164891017758E06728353
chr1910177871017841E06729651
chr1910178421017926E06729706
chr1910180581018350E06729922
chr1910184261018691E06730290
chr1910187601018893E06730624
chr19941664941993E068-46143
chr19983359983479E068-4657
chr19983553983756E068-4380
chr1910156081015844E06827472
chr1910158511016391E06827715
chr1910164891017758E06828353
chr1910177871017841E06829651
chr1910178421017926E06829706
chr1910180581018350E06829922
chr1910184261018691E06830290
chr1910187601018893E06830624
chr19941664941993E069-46143
chr19983359983479E069-4657
chr19983553983756E069-4380
chr19995473995566E0697337
chr1910158511016391E06927715
chr1910164891017758E06928353
chr1910177871017841E06929651
chr1910178421017926E06929706
chr1910180581018350E06929922
chr1910184261018691E06930290
chr1910187601018893E06930624
chr19940207940264E070-47872
chr19941664941993E070-46143
chr19942242942572E070-45564
chr19942585942669E070-45467
chr19944845945548E070-42588
chr19955812957516E070-30620
chr19983359983479E070-4657
chr19983553983756E070-4380
chr19985442985779E070-2357
chr19985854986068E070-2068
chr1910156081015844E07027472
chr1910158511016391E07027715
chr1910164891017758E07028353
chr1910177871017841E07029651
chr1910178421017926E07029706
chr1910180581018350E07029922
chr1910184261018691E07030290
chr1910187601018893E07030624
chr19940207940264E071-47872
chr19941664941993E071-46143
chr19983359983479E071-4657
chr19983553983756E071-4380
chr1910156081015844E07127472
chr1910158511016391E07127715
chr1910164891017758E07128353
chr1910177871017841E07129651
chr1910178421017926E07129706
chr1910180581018350E07129922
chr1910184261018691E07130290
chr1910187601018893E07130624
chr19941664941993E072-46143
chr19983359983479E072-4657
chr19983553983756E072-4380
chr1910158511016391E07227715
chr1910164891017758E07228353
chr1910177871017841E07229651
chr1910178421017926E07229706
chr1910180581018350E07229922
chr1910184261018691E07230290
chr1910187601018893E07230624
chr1910156081015844E07327472
chr1910158511016391E07327715
chr1910164891017758E07328353
chr1910177871017841E07329651
chr1910178421017926E07329706
chr1910180581018350E07329922
chr1910184261018691E07330290
chr1910187601018893E07330624
chr19941664941993E074-46143
chr19983359983479E074-4657
chr19983553983756E074-4380
chr1910158511016391E07427715
chr1910164891017758E07428353
chr1910177871017841E07429651
chr1910178421017926E07429706
chr1910180581018350E07429922
chr1910184261018691E07430290
chr1910187601018893E07430624
chr19940207940264E081-47872
chr19941664941993E081-46143
chr19983359983479E081-4657
chr19983553983756E081-4380
chr19985276985326E081-2810
chr19985442985779E081-2357
chr1910164891017758E08128353
chr1910177871017841E08129651
chr1910178421017926E08129706
chr1910180581018350E08129922
chr1910184261018691E08130290
chr1910187601018893E08130624
chr19940207940264E082-47872
chr19941664941993E082-46143
chr19944845945548E082-42588
chr19985276985326E082-2810
chr19985442985779E082-2357
chr19985854986068E082-2068
chr19986132986303E082-1833
chr19986710986821E082-1315
chr1910158511016391E08227715
chr1910164891017758E08228353
chr1910177871017841E08229651
chr1910178421017926E08229706
chr1910180581018350E08229922
chr1910184261018691E08230290
chr1910187601018893E08230624










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr19983831985184E067-2952
chr1910195561022221E06731420
chr1910259091029005E06737773
chr19983831985184E068-2952
chr1910195561022221E06831420
chr1910259091029005E06837773
chr19983831985184E069-2952
chr1910195561022221E06931420
chr1910259091029005E06937773
chr19983831985184E070-2952
chr1910195561022221E07031420
chr19983831985184E071-2952
chr1910195561022221E07131420
chr1910259091029005E07137773
chr19983831985184E072-2952
chr1910195561022221E07231420
chr1910259091029005E07237773
chr19983831985184E073-2952
chr1910195561022221E07331420
chr1910259091029005E07337773
chr19983831985184E074-2952
chr1910195561022221E07431420
chr1910259091029005E07437773
chr1910195561022221E08131420
chr19983831985184E082-2952
chr1910001181000408E08211982
chr1910195561022221E08231420
chr1910259091029005E08237773