rs7297654

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G==0429 (12803/29806,GnomAD)
G==0408 (11889/29118,TOPMED)
G==0444 (2224/5008,1000G)
G==0487 (1876/3854,ALSPAC)
G==0470 (1742/3708,TWINSUK)

Position: chr12:76019714 (GRCh38.p7) (12q21.2)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 31 Enhancers around

Promoter: 28 Promoters around

Sequence Name	Change(s)
GRCh38.p7 chr 12	NC_000012.12:g.76019714G>A
GRCh37.p13 chr 12	NC_000012.11:g.76413494G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.301	A=0.699
1000Genomes	American	Sub	694	G=0.520	A=0.480
1000Genomes	East Asian	Sub	1008	G=0.515	A=0.485
1000Genomes	Europe	Sub	1006	G=0.482	A=0.518
1000Genomes	Global	Study-wide	5008	G=0.444	A=0.556
1000Genomes	South Asian	Sub	978	G=0.470	A=0.530
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.487	A=0.513
The Genome Aggregation Database	African	Sub	8672	G=0.320	A=0.680
The Genome Aggregation Database	American	Sub	836	G=0.520	A=0.480
The Genome Aggregation Database	East Asian	Sub	1612	G=0.487	A=0.513
The Genome Aggregation Database	Europe	Sub	18384	G=0.470	A=0.529
The Genome Aggregation Database	Global	Study-wide	29806	G=0.429	A=0.570
The Genome Aggregation Database	Other	Sub	302	G=0.500	A=0.500
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.408	A=0.591
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.470	A=0.530

PMID	Title	Author	Journal
20158304	A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.	Lind PA	Twin Res Hum Genet

SNP ID	p-value	Traits	Study
rs7297654	5.09E-05	alcohol and nictotine co-dependence	20158304

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

There is no significant Hi-C chromatin interaction data for this SNP.

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr12	76371475	76372757	E067	-40737
chr12	76380235	76380460	E067	-33034
chr12	76448257	76448309	E067	34763
chr12	76371173	76371467	E068	-42027
chr12	76371475	76372757	E068	-40737
chr12	76379585	76380102	E068	-33392
chr12	76455060	76455147	E068	41566
chr12	76455183	76455314	E068	41689
chr12	76455320	76455375	E068	41826
chr12	76455466	76455516	E068	41972
chr12	76371475	76372757	E069	-40737
chr12	76456065	76456115	E069	42571
chr12	76375110	76375550	E070	-37944
chr12	76379585	76380102	E070	-33392
chr12	76371475	76372757	E071	-40737
chr12	76379475	76379555	E071	-33939
chr12	76379585	76380102	E071	-33392
chr12	76430652	76430809	E071	17158
chr12	76371475	76372757	E072	-40737
chr12	76371475	76372757	E073	-40737
chr12	76371475	76372757	E074	-40737
chr12	76430652	76430809	E074	17158
chr12	76430819	76431751	E074	17325
chr12	76455914	76456022	E074	42420
chr12	76456065	76456115	E074	42571
chr12	76463266	76463396	E074	49772
chr12	76401031	76401343	E081	-12151
chr12	76401402	76401712	E081	-11782
chr12	76421155	76421417	E081	7661
chr12	76421504	76421949	E081	8010
chr12	76427546	76427665	E081	14052

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr12	76421966	76423257	E067	8472
chr12	76423287	76423416	E067	9793
chr12	76423520	76427536	E067	10026
chr12	76421966	76423257	E068	8472
chr12	76423287	76423416	E068	9793
chr12	76423520	76427536	E068	10026
chr12	76421966	76423257	E069	8472
chr12	76423287	76423416	E069	9793
chr12	76423520	76427536	E069	10026
chr12	76421966	76423257	E070	8472
chr12	76423287	76423416	E070	9793
chr12	76421966	76423257	E071	8472
chr12	76423287	76423416	E071	9793
chr12	76423520	76427536	E071	10026
chr12	76421966	76423257	E072	8472
chr12	76423287	76423416	E072	9793
chr12	76423520	76427536	E072	10026
chr12	76421966	76423257	E073	8472
chr12	76423287	76423416	E073	9793
chr12	76423520	76427536	E073	10026
chr12	76423287	76423416	E074	9793
chr12	76423520	76427536	E074	10026
chr12	76421966	76423257	E081	8472
chr12	76423287	76423416	E081	9793
chr12	76423520	76427536	E081	10026
chr12	76421966	76423257	E082	8472
chr12	76423287	76423416	E082	9793
chr12	76423520	76427536	E082	10026