rs7303368

Homo sapiens
C>A / C>G / C>T
KSR2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0142 (4271/29970,GnomAD)
T=0155 (777/5008,1000G)
T=0098 (379/3854,ALSPAC)
T=0087 (323/3708,TWINSUK)
chr12:117697134 (GRCh38.p7) (12q24.22)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 12NC_000012.12:g.117697134C>A
GRCh38.p7 chr 12NC_000012.12:g.117697134C>G
GRCh38.p7 chr 12NC_000012.12:g.117697134C>T
GRCh37.p13 chr 12NC_000012.11:g.118134939C>A
GRCh37.p13 chr 12NC_000012.11:g.118134939C>G
GRCh37.p13 chr 12NC_000012.11:g.118134939C>T

Gene: KSR2, kinase suppressor of ras 2(minus strand)

Molecule type Change Amino acid[Codon] SO Term
KSR2 transcriptNM_173598.4:c.N/AIntron Variant
KSR2 transcript variant X1XM_011538224.2:c.N/AIntron Variant
KSR2 transcript variant X3XM_011538225.2:c.N/AIntron Variant
KSR2 transcript variant X4XM_011538226.2:c.N/AIntron Variant
KSR2 transcript variant X7XM_011538229.2:c.N/AIntron Variant
KSR2 transcript variant X2XM_017019208.1:c.N/AIntron Variant
KSR2 transcript variant X6XM_017019209.1:c.N/AIntron Variant
KSR2 transcript variant X5XM_011538228.2:c.N/AGenic Upstream Transcript Variant
KSR2 transcript variant X8XM_017019210.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.722T=0.278
1000GenomesAmericanSub694C=0.940T=0.060
1000GenomesEast AsianSub1008C=0.839T=0.161
1000GenomesEuropeSub1006C=0.921T=0.079
1000GenomesGlobalStudy-wide5008C=0.845T=0.155
1000GenomesSouth AsianSub978C=0.870T=0.130
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.902T=0.098
The Genome Aggregation DatabaseAfricanSub8714C=0.766G=0.000
The Genome Aggregation DatabaseAmericanSub838C=0.920G=0.00,
The Genome Aggregation DatabaseEast AsianSub1620C=0.833G=0.000
The Genome Aggregation DatabaseEuropeSub18496C=0.899G=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29970C=0.857G=0.000
The Genome Aggregation DatabaseOtherSub302C=0.870G=0.00,
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.913T=0.087
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs73033680.00071alcohol dependence20201924

eQTL of rs7303368 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7303368 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.