rs731590

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0312 (9332/29826,GnomAD)
T=0348 (10152/29118,TOPMED)
T=0371 (1860/5008,1000G)
T=0259 (999/3854,ALSPAC)
T=0234 (867/3708,TWINSUK)
chr5:133888397 (GRCh38.p7) (5q31.1)
AD
GWASdb2
1   publication(s)
See rs on genome
109 Enhancers around
7 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.133888397C>T
GRCh37.p13 chr 5NC_000005.9:g.133224088C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.432T=0.568
1000GenomesAmericanSub694C=0.660T=0.340
1000GenomesEast AsianSub1008C=0.721T=0.279
1000GenomesEuropeSub1006C=0.750T=0.250
1000GenomesGlobalStudy-wide5008C=0.629T=0.371
1000GenomesSouth AsianSub978C=0.650T=0.350
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.741T=0.259
The Genome Aggregation DatabaseAfricanSub8674C=0.518T=0.482
The Genome Aggregation DatabaseAmericanSub832C=0.690T=0.310
The Genome Aggregation DatabaseEast AsianSub1614C=0.707T=0.293
The Genome Aggregation DatabaseEuropeSub18404C=0.763T=0.236
The Genome Aggregation DatabaseGlobalStudy-wide29826C=0.687T=0.312
The Genome Aggregation DatabaseOtherSub302C=0.780T=0.220
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.651T=0.348
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.766T=0.234
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs7315900.000327alcohol dependence21314694

eQTL of rs731590 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs731590 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5133204610133204691E067-19397
chr5133204738133204861E067-19227
chr5133259858133260202E06735770
chr5133260253133260489E06736165
chr5133182575133182661E068-41427
chr5133182722133182808E068-41280
chr5133182913133182984E068-41104
chr5133244979133245605E06820891
chr5133245838133245934E06821750
chr5133246004133246054E06821916
chr5133246373133246516E06822285
chr5133259858133260202E06835770
chr5133269045133269397E06844957
chr5133175914133176059E069-48029
chr5133204738133204861E069-19227
chr5133206458133206756E069-17332
chr5133259858133260202E06935770
chr5133260253133260489E06936165
chr5133260602133260692E06936514
chr5133175425133175505E070-48583
chr5133175556133175715E070-48373
chr5133175914133176059E070-48029
chr5133179209133179259E070-44829
chr5133184653133184703E070-39385
chr5133185109133185153E070-38935
chr5133200957133201091E070-22997
chr5133204610133204691E070-19397
chr5133204738133204861E070-19227
chr5133205392133205579E070-18509
chr5133206458133206756E070-17332
chr5133212276133212336E070-11752
chr5133213039133213185E070-10903
chr5133213344133213449E070-10639
chr5133213490133214583E070-9505
chr5133216947133217002E070-7086
chr5133217489133217674E070-6414
chr5133217962133218032E070-6056
chr5133218641133218782E070-5306
chr5133218791133218845E070-5243
chr5133218954133219059E070-5029
chr5133236679133236846E07012591
chr5133236976133237276E07012888
chr5133242573133242914E07018485
chr5133242986133243078E07018898
chr5133243193133243289E07019105
chr5133244979133245605E07020891
chr5133245838133245934E07021750
chr5133246004133246054E07021916
chr5133246373133246516E07022285
chr5133257698133257820E07033610
chr5133257879133257975E07033791
chr5133259858133260202E07035770
chr5133260253133260489E07036165
chr5133260602133260692E07036514
chr5133261193133261253E07037105
chr5133261653133261837E07037565
chr5133262474133263218E07038386
chr5133263606133263671E07039518
chr5133175556133175715E071-48373
chr5133175914133176059E071-48029
chr5133260602133260692E07136514
chr5133269045133269397E07144957
chr5133269502133269737E07145414
chr5133259858133260202E07235770
chr5133260253133260489E07236165
chr5133260602133260692E07236514
chr5133269502133269737E07245414
chr5133244979133245605E07320891
chr5133259858133260202E07335770
chr5133260253133260489E07336165
chr5133265552133265665E07341464
chr5133259858133260202E07435770
chr5133260253133260489E07436165
chr5133260602133260692E07436514
chr5133216947133217002E081-7086
chr5133217489133217674E081-6414
chr5133236679133236846E08112591
chr5133236976133237276E08112888
chr5133242573133242914E08118485
chr5133242986133243078E08118898
chr5133243193133243289E08119105
chr5133245838133245934E08121750
chr5133246004133246054E08121916
chr5133246373133246516E08122285
chr5133257879133257975E08133791
chr5133259858133260202E08135770
chr5133260253133260489E08136165
chr5133260602133260692E08136514
chr5133261193133261253E08137105
chr5133261653133261837E08137565
chr5133262474133263218E08138386
chr5133216947133217002E082-7086
chr5133217489133217674E082-6414
chr5133217962133218032E082-6056
chr5133218641133218782E082-5306
chr5133218791133218845E082-5243
chr5133218954133219059E082-5029
chr5133242573133242914E08218485
chr5133242986133243078E08218898
chr5133243193133243289E08219105
chr5133245838133245934E08221750
chr5133246004133246054E08221916
chr5133246373133246516E08222285
chr5133259858133260202E08235770
chr5133260253133260489E08236165
chr5133260602133260692E08236514
chr5133261193133261253E08237105
chr5133261653133261837E08237565
chr5133262474133263218E08238386










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr5133204902133205320E067-18768
chr5133204902133205320E068-18768
chr5133204902133205320E069-18768
chr5133204902133205320E071-18768
chr5133204902133205320E072-18768
chr5133204902133205320E073-18768
chr5133204902133205320E074-18768