rs732459

Homo sapiens
C>T
PARN : Intron Variant
LOC107984865 : 2KB Upstream Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0217 (6516/29934,GnomAD)
T=0202 (5885/29118,TOPMED)
T=0135 (676/5008,1000G)
T=0255 (984/3854,ALSPAC)
T=0257 (952/3708,TWINSUK)
chr16:14533837 (GRCh38.p7) (16p13.12)
AD
GWASdb2
1   publication(s)
See rs on genome
134 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.14533837C>T
GRCh37.p13 chr 16NC_000016.9:g.14627694C>T
PARN RefSeqGeneNG_042871.1:g.101435G>A
GRCh38.p7 chr 16 alt locus HSCHR16_1_CTG1NT_187607.1:g.106694C>T

Gene: PARN, poly(A)-specific ribonuclease(minus strand)

Molecule type Change Amino acid[Codon] SO Term
PARN transcript variant 2NM_001134477.2:c.N/AIntron Variant
PARN transcript variant 3NM_001242992.1:c.N/AIntron Variant
PARN transcript variant 1NM_002582.3:c.N/AIntron Variant
PARN transcript variant X1XM_011522510.2:c.N/AIntron Variant
PARN transcript variant X2XM_011522511.2:c.N/AIntron Variant
PARN transcript variant X4XM_011522513.2:c.N/AIntron Variant
PARN transcript variant X3XM_017023258.1:c.N/AIntron Variant
PARN transcript variant X8XM_017023259.1:c.N/AIntron Variant
PARN transcript variant X10XM_017023260.1:c.N/AIntron Variant
PARN transcript variant X5XM_011522514.1:c.N/AGenic Downstream Transcript Variant
PARN transcript variant X6XR_001751906.1:n.N/AIntron Variant
PARN transcript variant X7XR_001751907.1:n.N/AGenic Downstream Transcript Variant

Gene: LOC107984865, uncharacterized LOC107984865(minus strand): 2KB Upstream Variant

Molecule type Change Amino acid[Codon] SO Term
LOC107984865 transcriptXR_001752089.1:n.N/AUpstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.883T=0.117
1000GenomesAmericanSub694C=0.860T=0.140
1000GenomesEast AsianSub1008C=0.992T=0.008
1000GenomesEuropeSub1006C=0.741T=0.259
1000GenomesGlobalStudy-wide5008C=0.865T=0.135
1000GenomesSouth AsianSub978C=0.840T=0.160
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.745T=0.255
The Genome Aggregation DatabaseAfricanSub8714C=0.863T=0.137
The Genome Aggregation DatabaseAmericanSub838C=0.860T=0.140
The Genome Aggregation DatabaseEast AsianSub1622C=0.997T=0.003
The Genome Aggregation DatabaseEuropeSub18460C=0.723T=0.276
The Genome Aggregation DatabaseGlobalStudy-wide29934C=0.782T=0.217
The Genome Aggregation DatabaseOtherSub300C=0.660T=0.340
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.797T=0.202
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.743T=0.257
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs7324590.000868alcohol dependence20201924

eQTL of rs732459 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs732459 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr161458389514583998E067-43696
chr161458408514584132E067-43562
chr161458414214584525E067-43169
chr161459517114596606E067-31088
chr161461284314612915E067-14779
chr161461313414613257E067-14437
chr161461329014613460E067-14234
chr161462276914623689E067-4005
chr161465366814653848E06725974
chr161465391414654087E06726220
chr161465659014657041E06728896
chr161465704214657317E06729348
chr161466026214660371E06732568
chr161466098014661177E06733286
chr161466127714661363E06733583
chr161458602814586196E068-41498
chr161458630914586533E068-41161
chr161459517114596606E068-31088
chr161459668714596849E068-30845
chr161459691914597753E068-29941
chr161459775714597868E068-29826
chr161460860414608719E068-18975
chr161462090714621170E068-6524
chr161465659014657041E06828896
chr161465704214657317E06829348
chr161465741014657527E06829716
chr161465772414657778E06830030
chr161465794814658052E06830254
chr161465816814658245E06830474
chr161465825214658531E06830558
chr161465856814659622E06830874
chr161466009514660191E06832401
chr161466026214660371E06832568
chr161466041114660480E06832717
chr161459078514590906E069-36788
chr161459091614590953E069-36741
chr161459462414594695E069-32999
chr161459517114596606E069-31088
chr161465366814653848E06925974
chr161465391414654087E06926220
chr161465417314654253E06926479
chr161466009514660191E06932401
chr161466026214660371E06932568
chr161466041114660480E06932717
chr161466063014660777E06932936
chr161464356314644036E07015869
chr161458992514590757E071-36937
chr161459078514590906E071-36788
chr161459091614590953E071-36741
chr161459462414594695E071-32999
chr161459476314594898E071-32796
chr161459490014595112E071-32582
chr161459517114596606E071-31088
chr161459668714596849E071-30845
chr161461284314612915E071-14779
chr161461313414613257E071-14437
chr161461329014613460E071-14234
chr161462121014622021E071-5673
chr161462209414622721E071-4973
chr161462276914623689E071-4005
chr161463315014633279E0715456
chr161463336414633475E0715670
chr161463356314633793E0715869
chr161463393114633991E0716237
chr161465366814653848E07125974
chr161465391414654087E07126220
chr161465417314654253E07126479
chr161465441914654488E07126725
chr161465449914654600E07126805
chr161466026214660371E07132568
chr161466041114660480E07132717
chr161466063014660777E07132936
chr161459078514590906E072-36788
chr161459091614590953E072-36741
chr161459099214591683E072-36011
chr161459434914594402E072-33292
chr161459462414594695E072-32999
chr161459476314594898E072-32796
chr161459490014595112E072-32582
chr161459517114596606E072-31088
chr161461032214610390E072-17304
chr161465659014657041E07228896
chr161465704214657317E07229348
chr161466009514660191E07232401
chr161466026214660371E07232568
chr161466041114660480E07232717
chr161466063014660777E07232936
chr161458602814586196E073-41498
chr161458630914586533E073-41161
chr161459517114596606E073-31088
chr161461722314617405E073-10289
chr161461763714617798E073-9896
chr161465366814653848E07325974
chr161465391414654087E07326220
chr161465417314654253E07326479
chr161465659014657041E07328896
chr161465704214657317E07329348
chr161465741014657527E07329716
chr161465772414657778E07330030
chr161465794814658052E07330254
chr161465816814658245E07330474
chr161465825214658531E07330558
chr161465856814659622E07330874
chr161466009514660191E07332401
chr161466026214660371E07332568
chr161466041114660480E07332717
chr161466063014660777E07332936
chr161459078514590906E074-36788
chr161459091614590953E074-36741
chr161459099214591683E074-36011
chr161459434914594402E074-33292
chr161459462414594695E074-32999
chr161459476314594898E074-32796
chr161459490014595112E074-32582
chr161459517114596606E074-31088
chr161461382414613929E074-13765
chr161461722314617405E074-10289
chr161461763714617798E074-9896
chr161462209414622721E074-4973
chr161465659014657041E07428896
chr161465704214657317E07429348
chr161466009514660191E07432401
chr161466026214660371E07432568
chr161466581114665861E07438117
chr161459091614590953E081-36741
chr161465366814653848E08125974
chr161465391414654087E08126220
chr161465417314654253E08126479
chr161465816814658245E08130474
chr161465825214658531E08130558
chr161465856814659622E08130874
chr161466009514660191E08132401
chr161466026214660371E08132568
chr161466009514660191E08232401