rs73411566

Homo sapiens
T>C
PARVA : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0011 (355/29982,GnomAD)
C=0016 (477/29118,TOPMED)
C=0016 (80/5008,1000G)
chr11:12433197 (GRCh38.p7) (11p15.3)
OD
GWASdb2
1   publication(s)
See rs on genome
140 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.12433197T>C
GRCh37.p13 chr 11NC_000011.9:g.12454744T>C

Gene: PARVA, parvin alpha(plus strand)

Molecule type Change Amino acid[Codon] SO Term
PARVA transcriptNM_018222.4:c.N/AIntron Variant
PARVA transcript variant X1XM_005253015.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.941C=0.059
1000GenomesAmericanSub694T=1.000C=0.000
1000GenomesEast AsianSub1008T=1.000C=0.000
1000GenomesEuropeSub1006T=1.000C=0.000
1000GenomesGlobalStudy-wide5008T=0.984C=0.016
1000GenomesSouth AsianSub978T=1.000C=0.000
The Genome Aggregation DatabaseAfricanSub8722T=0.960C=0.040
The Genome Aggregation DatabaseAmericanSub838T=1.000C=0.000
The Genome Aggregation DatabaseEast AsianSub1622T=1.000C=0.000
The Genome Aggregation DatabaseEuropeSub18498T=1.000C=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29982T=0.988C=0.011
The Genome Aggregation DatabaseOtherSub302T=1.000C=0.000
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.983C=0.016
PMID Title Author Journal
24143882Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.Gelernter JBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs734115661.75E-08Opioid sensitivity24143882

eQTL of rs73411566 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs73411566 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr111242576412425903E067-28841
chr111242602512426289E067-28455
chr111243101312431097E067-23647
chr111243114512432325E067-22419
chr111243249212432584E067-22160
chr111243328212434468E067-20276
chr111243454012434647E067-20097
chr111243477512434931E067-19813
chr111247863612479379E06723892
chr111247948212479582E06724738
chr111247967412479805E06724930
chr111248202212482381E06727278
chr111248246712482528E06727723
chr111248258112483038E06727837
chr111248314512483480E06728401
chr111241193212412760E068-41984
chr111242576412425903E068-28841
chr111242602512426289E068-28455
chr111242630512426477E068-28267
chr111243114512432325E068-22419
chr111243328212434468E068-20276
chr111243454012434647E068-20097
chr111243477512434931E068-19813
chr111243646912436542E068-18202
chr111245165312453150E068-1594
chr111245464312456422E0680
chr111248202212482381E06827278
chr111248246712482528E06827723
chr111249391912494002E06839175
chr111249402512494503E06839281
chr111249461312494714E06839869
chr111249477112494872E06840027
chr111243114512432325E069-22419
chr111243249212432584E069-22160
chr111243477512434931E069-19813
chr111243498212436166E069-18578
chr111247967412479805E06924930
chr111247984212480596E06925098
chr111248202212482381E06927278
chr111248246712482528E06927723
chr111249402512494503E06939281
chr111249461312494714E06939869
chr111249477112494872E06940027
chr111242449312424745E070-29999
chr111242478712424898E070-29846
chr111242499312425084E070-29660
chr111242531312425420E070-29324
chr111242552212425725E070-29019
chr111242576412425903E070-28841
chr111242602512426289E070-28455
chr111242630512426477E070-28267
chr111243454012434647E070-20097
chr111243477512434931E070-19813
chr111243498212436166E070-18578
chr111245165312453150E070-1594
chr111245464312456422E0700
chr111247830312478527E07023559
chr111247863612479379E07023892
chr111249391912494002E07039175
chr111241113912411882E071-42862
chr111241193212412760E071-41984
chr111242576412425903E071-28841
chr111242602512426289E071-28455
chr111242630512426477E071-28267
chr111243114512432325E071-22419
chr111243328212434468E071-20276
chr111243454012434647E071-20097
chr111243477512434931E071-19813
chr111243498212436166E071-18578
chr111245464312456422E0710
chr111245642912456828E0711685
chr111241193212412760E072-41984
chr111242531312425420E072-29324
chr111242552212425725E072-29019
chr111243114512432325E072-22419
chr111243249212432584E072-22160
chr111245165312453150E072-1594
chr111245335012453489E072-1255
chr111248246712482528E07227723
chr111248258112483038E07227837
chr111241113912411882E073-42862
chr111241193212412760E073-41984
chr111241886512420049E073-34695
chr111243114512432325E073-22419
chr111243249212432584E073-22160
chr111243454012434647E073-20097
chr111243477512434931E073-19813
chr111243498212436166E073-18578
chr111245464312456422E0730
chr111247801212478276E07323268
chr111247830312478527E07323559
chr111247863612479379E07323892
chr111247948212479582E07324738
chr111247967412479805E07324930
chr111247984212480596E07325098
chr111248061612480680E07325872
chr111248071212480872E07325968
chr111248148812481865E07326744
chr111248202212482381E07327278
chr111248246712482528E07327723
chr111248258112483038E07327837
chr111249477112494872E07340027
chr111249490012494958E07340156
chr111249496212495022E07340218
chr111249508012495278E07340336
chr111242602512426289E074-28455
chr111242630512426477E074-28267
chr111243454012434647E074-20097
chr111243477512434931E074-19813
chr111249391912494002E07439175
chr111249402512494503E07439281
chr111241113912411882E081-42862
chr111241193212412760E081-41984
chr111241277712412884E081-41860
chr111241299312413053E081-41691
chr111243626512436462E081-18282
chr111243646912436542E081-18202
chr111243657612436883E081-17861
chr111243691012437162E081-17582
chr111243830312438384E081-16360
chr111245397212454068E081-676
chr111245425712454317E081-427
chr111245432012454373E081-371
chr111245443712454527E081-217
chr111245464312456422E0810
chr111245642912456828E0811685
chr111245685512457239E0812111
chr111249391912494002E08139175
chr111249402512494503E08139281
chr111241193212412760E082-41984
chr111241277712412884E082-41860
chr111242576412425903E082-28841
chr111242602512426289E082-28455
chr111242630512426477E082-28267
chr111243454012434647E082-20097
chr111245464312456422E0820
chr111245642912456828E0821685
chr111245685512457239E0822111
chr111246266612463446E0827922
chr111247863612479379E08223892