rs73459955

Homo sapiens
C>T
LOC105370991 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0160 (4800/29926,GnomAD)
T=0181 (5272/29118,TOPMED)
T=0239 (1195/5008,1000G)
T=0148 (569/3854,ALSPAC)
T=0139 (515/3708,TWINSUK)
chr15:95109294 (GRCh38.p7) (15q26.2)
AD
GWASCatalog
1   publication(s)
See rs on genome
16 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.95109294C>T
GRCh37.p13 chr 15NC_000015.9:g.95652523C>T

Gene: LOC105370991, uncharacterized LOC105370991(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105370991 transcriptXR_001751682.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.839T=0.161
1000GenomesAmericanSub694C=0.660T=0.340
1000GenomesEast AsianSub1008C=0.670T=0.330
1000GenomesEuropeSub1006C=0.855T=0.145
1000GenomesGlobalStudy-wide5008C=0.761T=0.239
1000GenomesSouth AsianSub978C=0.730T=0.270
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.852T=0.148
The Genome Aggregation DatabaseAfricanSub8708C=0.842T=0.158
The Genome Aggregation DatabaseAmericanSub832C=0.630T=0.370
The Genome Aggregation DatabaseEast AsianSub1616C=0.686T=0.314
The Genome Aggregation DatabaseEuropeSub18468C=0.862T=0.137
The Genome Aggregation DatabaseGlobalStudy-wide29926C=0.839T=0.160
The Genome Aggregation DatabaseOtherSub302C=0.770T=0.230
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.818T=0.181
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.861T=0.139
PMID Title Author Journal
29071344Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.Zhou HJAMA Psychiatry

P-Value

SNP ID p-value Traits Study
rs734599552E-06alcohol dependence29071344

eQTL of rs73459955 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs73459955 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr159561136295611466E081-41057
chr159561154795611889E081-40634
chr159561198095612443E081-40080
chr159561250095612609E081-39914
chr159561289795612947E081-39576
chr159561913995619189E081-33334
chr159561934795619663E081-32860
chr159569213995692189E08139616
chr159569237995692539E08139856
chr159569277495692836E08140251
chr159569287695693629E08140353
chr159569381395694149E08141290
chr159561154795611889E082-40634
chr159561198095612443E082-40080
chr159569213995692189E08239616
chr159569237995692539E08239856