rs7411728

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0066 (1993/29980,GnomAD)
A=0042 (1242/29118,TOPMED)
A=0083 (416/5008,1000G)
A=0065 (251/3854,ALSPAC)
A=0063 (234/3708,TWINSUK)
chr1:59981117 (GRCh38.p7) (1p32.1)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.59981117G>A
GRCh37.p13 chr 1NC_000001.10:g.60446789G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.989A=0.011
1000GenomesAmericanSub694G=0.920A=0.080
1000GenomesEast AsianSub1008G=0.833A=0.167
1000GenomesEuropeSub1006G=0.923A=0.077
1000GenomesGlobalStudy-wide5008G=0.917A=0.083
1000GenomesSouth AsianSub978G=0.900A=0.100
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.935A=0.065
The Genome Aggregation DatabaseAfricanSub8728G=0.982A=0.018
The Genome Aggregation DatabaseAmericanSub836G=0.900A=0.100
The Genome Aggregation DatabaseEast AsianSub1620G=0.840A=0.160
The Genome Aggregation DatabaseEuropeSub18494G=0.921A=0.078
The Genome Aggregation DatabaseGlobalStudy-wide29980G=0.933A=0.066
The Genome Aggregation DatabaseOtherSub302G=0.870A=0.130
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.957A=0.042
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.937A=0.063
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs74117280.00063alcohol consumption (maxi-drinks)24277619

eQTL of rs7411728 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7411728 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr16041293460413362E067-33427
chr16043702860437601E067-9188
chr16043771560438767E067-8022
chr16044208260442856E067-3933
chr16041337260413492E068-33297
chr16043771560438767E068-8022
chr16045317760453357E0686388
chr16041165060411775E069-35014
chr16041188460411971E069-34818
chr16041337260413492E069-33297
chr16043702860437601E069-9188
chr16043771560438767E069-8022
chr16048316360483222E06936374
chr16043702860437601E070-9188
chr16043913960439214E070-7575
chr16044422360444535E070-2254
chr16045225960452504E0705470
chr16045317760453357E0706388
chr16048316360483222E07036374
chr16041165060411775E071-35014
chr16041293460413362E071-33427
chr16041337260413492E071-33297
chr16044208260442856E071-3933
chr16041165060411775E072-35014
chr16041188460411971E072-34818
chr16041337260413492E072-33297
chr16043771560438767E072-8022
chr16041293460413362E073-33427
chr16041337260413492E073-33297
chr16043702860437601E073-9188
chr16044208260442856E073-3933
chr16041165060411775E074-35014
chr16041293460413362E074-33427
chr16041337260413492E074-33297
chr16043702860437601E074-9188
chr16043771560438767E074-8022
chr16044208260442856E074-3933
chr16045225960452504E0745470
chr16043702860437601E081-9188
chr16043771560438767E081-8022
chr16043913960439214E081-7575
chr16044208260442856E081-3933
chr16046557860465656E08118789
chr16046601560466281E08119226
chr16043913960439214E082-7575
chr16043940860439463E082-7326
chr16043953660439609E082-7180
chr16045155660452153E0824767
chr16045225960452504E0825470
chr16045258260453055E0825793