rs7428007

Homo sapiens
A>G
PROS1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0361 (10829/29926,GnomAD)
G=0313 (9141/29118,TOPMED)
G=0392 (1961/5008,1000G)
G=0436 (1682/3854,ALSPAC)
G=0422 (1565/3708,TWINSUK)
chr3:93919173 (GRCh38.p7) (3q11.1)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.93919173A>G
GRCh37.p13 chr 3NC_000003.11:g.93638017A>G
PROS1 RefSeqGene LRG_572

Gene: PROS1, protein S (alpha)(minus strand)

Molecule type Change Amino acid[Codon] SO Term
PROS1 transcript variant 2NM_000313.3:c.N/AIntron Variant
PROS1 transcript variant 1NM_001314077.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.890G=0.110
1000GenomesAmericanSub694A=0.530G=0.470
1000GenomesEast AsianSub1008A=0.436G=0.564
1000GenomesEuropeSub1006A=0.570G=0.430
1000GenomesGlobalStudy-wide5008A=0.608G=0.392
1000GenomesSouth AsianSub978A=0.500G=0.500
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.564G=0.436
The Genome Aggregation DatabaseAfricanSub8720A=0.844G=0.156
The Genome Aggregation DatabaseAmericanSub830A=0.570G=0.430
The Genome Aggregation DatabaseEast AsianSub1614A=0.462G=0.538
The Genome Aggregation DatabaseEuropeSub18460A=0.558G=0.441
The Genome Aggregation DatabaseGlobalStudy-wide29926A=0.638G=0.361
The Genome Aggregation DatabaseOtherSub302A=0.720G=0.280
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.686G=0.313
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.578G=0.422
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs74280070.000477alcohol dependence21314694

eQTL of rs7428007 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7428007 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.