rs742977

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
G==0354 (10597/29922,GnomAD)
G==0364 (10624/29114,TOPMED)
G==0380 (1902/5008,1000G)
G==0399 (1538/3854,ALSPAC)
G==0406 (1505/3708,TWINSUK)
chr22:48982682 (GRCh38.p7) (22q13.32)
ND
GWASdb2
1   publication(s)
See rs on genome
134 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 22NC_000022.11:g.48982682G>A
GRCh37.p13 chr 22NC_000022.10:g.49378494G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.295A=0.705
1000GenomesAmericanSub694G=0.500A=0.500
1000GenomesEast AsianSub1008G=0.325A=0.675
1000GenomesEuropeSub1006G=0.393A=0.607
1000GenomesGlobalStudy-wide5008G=0.380A=0.620
1000GenomesSouth AsianSub978G=0.460A=0.540
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.399A=0.601
The Genome Aggregation DatabaseAfricanSub8712G=0.303A=0.697
The Genome Aggregation DatabaseAmericanSub838G=0.490A=0.510
The Genome Aggregation DatabaseEast AsianSub1616G=0.335A=0.665
The Genome Aggregation DatabaseEuropeSub18454G=0.374A=0.625
The Genome Aggregation DatabaseGlobalStudy-wide29922G=0.354A=0.645
The Genome Aggregation DatabaseOtherSub302G=0.350A=0.650
Trans-Omics for Precision MedicineGlobalStudy-wide29114G=0.364A=0.635
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.406A=0.594
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs7429770.000246nicotine dependence17158188

eQTL of rs742977 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs742977 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr224933890949338997E067-39497
chr224933899849339058E067-39436
chr224933907349339123E067-39371
chr224933953649339927E067-38567
chr224934000849340068E067-38426
chr224934027549340352E067-38142
chr224934051049340696E067-37798
chr224934099449341034E067-37460
chr224942257449423182E06744080
chr224933890949338997E068-39497
chr224933899849339058E068-39436
chr224933907349339123E068-39371
chr224933953649339927E068-38567
chr224934000849340068E068-38426
chr224933890949338997E069-39497
chr224933899849339058E069-39436
chr224933907349339123E069-39371
chr224933953649339927E069-38567
chr224934000849340068E069-38426
chr224934027549340352E069-38142
chr224934051049340696E069-37798
chr224934099449341034E069-37460
chr224934108549341135E069-37359
chr224934117649341216E069-37278
chr224942199649422521E06943502
chr224942257449423182E06944080
chr224933890949338997E070-39497
chr224933899849339058E070-39436
chr224933907349339123E070-39371
chr224935857049358773E070-19721
chr224935954949359627E070-18867
chr224937666849376718E070-1776
chr224937674549376795E070-1699
chr224937683849376895E070-1599
chr224937711849377397E070-1097
chr224940594049406073E07027446
chr224940789549408148E07029401
chr224940833349408383E07029839
chr224940842849408478E07029934
chr224940850449409288E07030010
chr224941183349411883E07033339
chr224941189649412115E07033402
chr224941221449412364E07033720
chr224942199649422521E07043502
chr224942257449423182E07044080
chr224933890949338997E071-39497
chr224933899849339058E071-39436
chr224933907349339123E071-39371
chr224933953649339927E071-38567
chr224934000849340068E071-38426
chr224934027549340352E071-38142
chr224934051049340696E071-37798
chr224940842849408478E07129934
chr224942199649422521E07143502
chr224942257449423182E07144080
chr224933890949338997E072-39497
chr224933899849339058E072-39436
chr224933907349339123E072-39371
chr224933953649339927E072-38567
chr224934000849340068E072-38426
chr224934027549340352E072-38142
chr224934051049340696E072-37798
chr224934099449341034E072-37460
chr224942257449423182E07244080
chr224933434249334405E073-44089
chr224933899849339058E073-39436
chr224933907349339123E073-39371
chr224933953649339927E073-38567
chr224934000849340068E073-38426
chr224934099449341034E073-37460
chr224942257449423182E07344080
chr224933890949338997E074-39497
chr224933899849339058E074-39436
chr224933907349339123E074-39371
chr224933953649339927E074-38567
chr224934000849340068E074-38426
chr224942257449423182E07444080
chr224934603049346080E081-32414
chr224935916449359503E081-18991
chr224935954949359627E081-18867
chr224937631049376438E081-2056
chr224937666849376718E081-1776
chr224937674549376795E081-1699
chr224937683849376895E081-1599
chr224940594049406073E08127446
chr224940625749406307E08127763
chr224940729849407451E08128804
chr224940789549408148E08129401
chr224940833349408383E08129839
chr224940842849408478E08129934
chr224940850449409288E08130010
chr224941016849410261E08131674
chr224941035049410567E08131856
chr224941068449410840E08132190
chr224941183349411883E08133339
chr224941189649412115E08133402
chr224941732849417546E08138834
chr224941757849418520E08139084
chr224941966849419773E08141174
chr224942039049420430E08141896
chr224942131049421463E08142816
chr224942180349421852E08143309
chr224942199649422521E08143502
chr224942257449423182E08144080
chr224942387549423925E08145381
chr224942401349424063E08145519
chr224942451949424559E08146025
chr224942459049424645E08146096
chr224942493449425118E08146440
chr224942662049426940E08148126
chr224942698849427038E08148494
chr224937711849377397E082-1097
chr224940594049406073E08227446
chr224940625749406307E08227763
chr224940667849406749E08228184
chr224940692849406985E08228434
chr224940717649407230E08228682
chr224940729849407451E08228804
chr224940789549408148E08229401
chr224940833349408383E08229839
chr224940842849408478E08229934
chr224940850449409288E08230010
chr224941016849410261E08231674
chr224941035049410567E08231856
chr224941732849417546E08238834
chr224941757849418520E08239084
chr224942131049421463E08242816
chr224942180349421852E08243309
chr224942199649422521E08243502
chr224942257449423182E08244080
chr224942387549423925E08245381
chr224942401349424063E08245519
chr224942451949424559E08246025
chr224942459049424645E08246096