rs7431637

Homo sapiens
T>C
SLC9A9 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0277 (8300/29948,GnomAD)
T==0249 (7254/29118,TOPMED)
T==0358 (1794/5008,1000G)
T==0388 (1496/3854,ALSPAC)
T==0398 (1474/3708,TWINSUK)
chr3:143330927 (GRCh38.p7) (3q24)
AD
GWASdb2
1   publication(s)
See rs on genome
133 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.143330927T>C
GRCh37.p13 chr 3NC_000003.11:g.143049769T>C
SLC9A9 RefSeqGeneNG_017077.1:g.522605A>G

Gene: SLC9A9, solute carrier family 9 member A9(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SLC9A9 transcriptNM_173653.3:c.N/AIntron Variant
SLC9A9 transcript variant X3XM_011512703.2:c.N/AIntron Variant
SLC9A9 transcript variant X1XM_017006202.1:c.N/AIntron Variant
SLC9A9 transcript variant X2XM_017006203.1:c.N/AIntron Variant
SLC9A9 transcript variant X4XM_011512704.2:c.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.043C=0.957
1000GenomesAmericanSub694T=0.340C=0.660
1000GenomesEast AsianSub1008T=0.598C=0.402
1000GenomesEuropeSub1006T=0.379C=0.621
1000GenomesGlobalStudy-wide5008T=0.358C=0.642
1000GenomesSouth AsianSub978T=0.530C=0.470
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.388C=0.612
The Genome Aggregation DatabaseAfricanSub8720T=0.085C=0.915
The Genome Aggregation DatabaseAmericanSub834T=0.350C=0.650
The Genome Aggregation DatabaseEast AsianSub1620T=0.604C=0.396
The Genome Aggregation DatabaseEuropeSub18472T=0.334C=0.665
The Genome Aggregation DatabaseGlobalStudy-wide29948T=0.277C=0.722
The Genome Aggregation DatabaseOtherSub302T=0.380C=0.620
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.249C=0.750
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.398C=0.602
PMID Title Author Journal
23089632A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.Wang JCMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs74316370.00000758alcohol dependence23089632
rs74316370.00036alcohol dependence23089632

eQTL of rs7431637 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7431637 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3143005328143005569E067-44200
chr3143006343143006541E067-43228
chr3143007784143008171E067-41598
chr3143010645143010841E067-38928
chr3143010853143010944E067-38825
chr3143010975143011211E067-38558
chr3143048485143048606E067-1163
chr3143049956143050074E067187
chr3143050233143050516E067464
chr3143061820143062271E06712051
chr3143062591143062850E06712822
chr3143005328143005569E068-44200
chr3143006343143006541E068-43228
chr3143007784143008171E068-41598
chr3143010645143010841E068-38928
chr3143010853143010944E068-38825
chr3143010975143011211E068-38558
chr3143032753143033804E068-15965
chr3143034598143034658E068-15111
chr3143048485143048606E068-1163
chr3143048684143049027E068-742
chr3143049079143049314E068-455
chr3143049352143049544E068-225
chr3143049735143049860E0680
chr3143049956143050074E068187
chr3143050233143050516E068464
chr3143062591143062850E06812822
chr3143077113143077227E06827344
chr3143077303143077353E06827534
chr3143077831143077881E06828062
chr3143078088143078343E06828319
chr3143005328143005569E069-44200
chr3143006343143006541E069-43228
chr3143007784143008171E069-41598
chr3143048485143048606E069-1163
chr3143048684143049027E069-742
chr3143049079143049314E069-455
chr3143049352143049544E069-225
chr3143049735143049860E0690
chr3143049956143050074E069187
chr3143050233143050516E069464
chr3143077113143077227E06927344
chr3143077303143077353E06927534
chr3143077831143077881E06928062
chr3143078088143078343E06928319
chr3143005328143005569E071-44200
chr3143006343143006541E071-43228
chr3143007784143008171E071-41598
chr3143009279143009333E071-40436
chr3143010645143010841E071-38928
chr3143010853143010944E071-38825
chr3143010975143011211E071-38558
chr3143032753143033804E071-15965
chr3143034598143034658E071-15111
chr3143049352143049544E071-225
chr3143049735143049860E0710
chr3143049956143050074E071187
chr3143050233143050516E071464
chr3143050544143051256E071775
chr3143062591143062850E07112822
chr3143077113143077227E07127344
chr3143077303143077353E07127534
chr3143003002143003052E072-46717
chr3143005328143005569E072-44200
chr3143007784143008171E072-41598
chr3143010645143010841E072-38928
chr3143010853143010944E072-38825
chr3143021314143021457E072-28312
chr3143021458143022149E072-27620
chr3143048485143048606E072-1163
chr3143049352143049544E072-225
chr3143049735143049860E0720
chr3143049956143050074E072187
chr3143050233143050516E072464
chr3143077113143077227E07227344
chr3143077303143077353E07227534
chr3143077831143077881E07228062
chr3143078088143078343E07228319
chr3143006343143006541E073-43228
chr3143010645143010841E073-38928
chr3143010853143010944E073-38825
chr3143048485143048606E073-1163
chr3143048684143049027E073-742
chr3143049735143049860E0730
chr3143049956143050074E073187
chr3143005328143005569E074-44200
chr3143006343143006541E074-43228
chr3143007784143008171E074-41598
chr3143009279143009333E074-40436
chr3143010645143010841E074-38928
chr3143010853143010944E074-38825
chr3143010975143011211E074-38558
chr3143011654143011704E074-38065
chr3143013051143013262E074-36507
chr3143013443143013493E074-36276
chr3143014045143014150E074-35619
chr3143014155143014380E074-35389
chr3143014610143015052E074-34717
chr3143015154143015214E074-34555
chr3143049079143049314E074-455
chr3143049352143049544E074-225
chr3143049735143049860E0740
chr3143049956143050074E074187
chr3143050233143050516E074464
chr3143062591143062850E07412822
chr3143062891143063112E07413122
chr3143063169143063255E07413400
chr3143063497143063728E07413728
chr3143077113143077227E07427344
chr3143077303143077353E07427534
chr3143077831143077881E07428062
chr3143078088143078343E07428319
chr3143032753143033804E081-15965
chr3143047831143047907E081-1862
chr3143048485143048606E081-1163
chr3143048684143049027E081-742
chr3143049079143049314E081-455
chr3143049352143049544E081-225
chr3143049735143049860E0810
chr3143049956143050074E081187
chr3143050233143050516E081464
chr3143050544143051256E081775
chr3143052386143052488E0812617
chr3143047365143047584E082-2185
chr3143047831143047907E082-1862
chr3143048485143048606E082-1163
chr3143048684143049027E082-742
chr3143049079143049314E082-455
chr3143049352143049544E082-225
chr3143049735143049860E0820
chr3143049956143050074E082187
chr3143051973143052092E0822204
chr3143052386143052488E0822617