rs74335618

Homo sapiens
T>C
ST7 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0021 (639/29972,GnomAD)
C=0022 (642/29118,TOPMED)
C=0053 (263/5008,1000G)
C=0020 (77/3854,ALSPAC)
C=0023 (87/3708,TWINSUK)
chr7:117175543 (GRCh38.p7) (7q31.2)
AD
GWASCatalog
1   publication(s)
See rs on genome
68 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.117175543T>C
GRCh37.p13 chr 7NC_000007.13:g.116815597T>C

Gene: ST7, suppression of tumorigenicity 7(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ST7 transcript variant aNM_018412.3:c.N/AIntron Variant
ST7 transcript variant bNM_021908.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.997C=0.003
1000GenomesAmericanSub694T=0.940C=0.060
1000GenomesEast AsianSub1008T=0.853C=0.147
1000GenomesEuropeSub1006T=0.985C=0.015
1000GenomesGlobalStudy-wide5008T=0.947C=0.053
1000GenomesSouth AsianSub978T=0.950C=0.050
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.980C=0.020
The Genome Aggregation DatabaseAfricanSub8726T=0.996C=0.004
The Genome Aggregation DatabaseAmericanSub836T=0.920C=0.080
The Genome Aggregation DatabaseEast AsianSub1610T=0.835C=0.165
The Genome Aggregation DatabaseEuropeSub18498T=0.986C=0.013
The Genome Aggregation DatabaseGlobalStudy-wide29972T=0.978C=0.021
The Genome Aggregation DatabaseOtherSub302T=0.980C=0.020
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.978C=0.022
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.977C=0.023
PMID Title Author Journal
29460428Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.Gelernter JAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs743356183E-06response to alcohol29460428

eQTL of rs74335618 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs74335618 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7116792693116793238E067-22359
chr7116796897116797207E067-18390
chr7116797249116798167E067-17430
chr7116798214116798440E067-17157
chr7116798503116798713E067-16884
chr7116765921116766022E068-49575
chr7116766076116766218E068-49379
chr7116766448116766498E068-49099
chr7116766513116766728E068-48869
chr7116766767116766844E068-48753
chr7116786238116786844E068-28753
chr7116787296116787388E068-28209
chr7116797249116798167E068-17430
chr7116798214116798440E068-17157
chr7116798503116798713E068-16884
chr7116798760116798874E068-16723
chr7116812750116812842E068-2755
chr7116765643116765721E069-49876
chr7116765921116766022E069-49575
chr7116766076116766218E069-49379
chr7116766448116766498E069-49099
chr7116766513116766728E069-48869
chr7116766767116766844E069-48753
chr7116766866116767055E069-48542
chr7116767129116767271E069-48326
chr7116797249116798167E069-17430
chr7116798214116798440E069-17157
chr7116798503116798713E069-16884
chr7116798760116798874E069-16723
chr7116766448116766498E070-49099
chr7116766513116766728E070-48869
chr7116766767116766844E070-48753
chr7116766866116767055E070-48542
chr7116767129116767271E070-48326
chr7116796897116797207E070-18390
chr7116797249116798167E070-17430
chr7116814913116815084E070-513
chr7116815196116815300E070-297
chr7116766513116766728E071-48869
chr7116766767116766844E071-48753
chr7116766866116767055E071-48542
chr7116796897116797207E071-18390
chr7116797249116798167E071-17430
chr7116766513116766728E072-48869
chr7116766767116766844E072-48753
chr7116766866116767055E072-48542
chr7116797249116798167E072-17430
chr7116811281116811397E072-4200
chr7116766448116766498E073-49099
chr7116766513116766728E073-48869
chr7116766767116766844E073-48753
chr7116766866116767055E073-48542
chr7116797249116798167E073-17430
chr7116766767116766844E074-48753
chr7116767129116767271E074-48326
chr7116796751116796841E074-18756
chr7116796897116797207E074-18390
chr7116797249116798167E074-17430
chr7116798214116798440E074-17157
chr7116798503116798713E074-16884
chr7116766513116766728E081-48869
chr7116766767116766844E081-48753
chr7116766866116767055E081-48542
chr7116856897116856937E08141300
chr7116857036116857086E08141439
chr7116857127116857184E08141530
chr7116857616116857696E08242019
chr7116857862116858057E08242265