rs7445832

Homo sapiens
T>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0254 (7549/29688,GnomAD)
A=0296 (8635/29118,TOPMED)
A=0236 (1180/5008,1000G)
A=0246 (948/3854,ALSPAC)
A=0240 (891/3708,TWINSUK)
chr5:63290474 (GRCh38.p7) (5q12.1)
AD | ND
GWASdb2 | GWASCatalog
5   publication(s)
See rs on genome
8 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.63290474T>A
GRCh37.p13 chr 5NC_000005.9:g.62586301T>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.570A=0.430
1000GenomesAmericanSub694T=0.790A=0.210
1000GenomesEast AsianSub1008T=0.877A=0.123
1000GenomesEuropeSub1006T=0.778A=0.222
1000GenomesGlobalStudy-wide5008T=0.764A=0.236
1000GenomesSouth AsianSub978T=0.880A=0.120
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.754A=0.246
The Genome Aggregation DatabaseAfricanSub8668T=0.612A=0.388
The Genome Aggregation DatabaseAmericanSub828T=0.800A=0.200
The Genome Aggregation DatabaseEast AsianSub1554T=0.856A=0.144
The Genome Aggregation DatabaseEuropeSub18336T=0.797A=0.202
The Genome Aggregation DatabaseGlobalStudy-wide29688T=0.745A=0.254
The Genome Aggregation DatabaseOtherSub302T=0.730A=0.270
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.703A=0.296
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.760A=0.240
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.Zuo LNeuropsychopharmacology
20202923A genome-wide association study of alcohol dependence.Bierut LJProc Natl Acad Sci U S A
23216389Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.Zuo LAlcohol Clin Exp Res
22488850Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.Zuo LAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs74458320.000000001alcohol and nictotine co-dependence23216389
rs74458320.000000007alcohol and nictotine co-dependence22488850
rs74458320.00000226alcohol dependence20202923
rs74458320.0000304alcohol dependence21703634
rs74458320.00042alcohol dependence21956439

eQTL of rs7445832 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7445832 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr56253634362536420E069-49881
chr56253646562536519E069-49782
chr56253634362536420E072-49881
chr56253646562536519E072-49782
chr56253634362536420E074-49881
chr56253646562536519E074-49782
chr56253634362536420E082-49881
chr56253646562536519E082-49782