rs7453746

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0387 (11595/29918,GnomAD)
G=0335 (9770/29118,TOPMED)
G=0403 (2016/5008,1000G)
chr6:80100296 (GRCh38.p7) (6q14.1)
AD
GWASdb2
1   publication(s)
See rs on genome
41 Enhancers around
15 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.80100296T>G
GRCh37.p13 chr 6NC_000006.11:g.80810013T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.931G=0.069
1000GenomesAmericanSub694T=0.360G=0.640
1000GenomesEast AsianSub1008T=0.438G=0.562
1000GenomesEuropeSub1006T=0.489G=0.511
1000GenomesGlobalStudy-wide5008T=0.597G=0.403
1000GenomesSouth AsianSub978T=0.590G=0.410
The Genome Aggregation DatabaseAfricanSub8712T=0.869G=0.131
The Genome Aggregation DatabaseAmericanSub838T=0.360G=0.640
The Genome Aggregation DatabaseEast AsianSub1608T=0.437G=0.563
The Genome Aggregation DatabaseEuropeSub18458T=0.520G=0.479
The Genome Aggregation DatabaseGlobalStudy-wide29918T=0.612G=0.387
The Genome Aggregation DatabaseOtherSub302T=0.480G=0.520
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.664G=0.335
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs74537460.00000786alcoholismpha002893
rs74537460.0000079alcohol dependence20201924
rs74537460.000071alcohol dependence(early age of onset)20201924
rs74537460.0000712alcoholismpha002892

eQTL of rs7453746 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7453746 in Fetal Brain

Probe ID Position Gene beta p-value
cg08355045chr6:807875290.03595341130312552.2960e-9

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr68081536380815467E0675350
chr68081734580817622E0677332
chr68085302180853694E06743008
chr68085455480854678E06744541
chr68085480880854908E06744795
chr68085495980855036E06744946
chr68081536380815467E0685350
chr68081734580817622E0687332
chr68084275980843044E06832746
chr68085288080852935E06842867
chr68085302180853694E06843008
chr68081536380815467E0695350
chr68081734580817622E0697332
chr68084275980843044E06932746
chr68085288080852935E06942867
chr68085302180853694E07043008
chr68081734580817622E0717332
chr68085302180853694E07143008
chr68085381380853863E07143800
chr68085402180854071E07144008
chr68085455480854678E07144541
chr68085480880854908E07144795
chr68085495980855036E07144946
chr68081734580817622E0727332
chr68085288080852935E07242867
chr68085302180853694E07243008
chr68085288080852935E07342867
chr68085302180853694E07343008
chr68081734580817622E0747332
chr68085455480854678E07444541
chr68085302180853694E08143008
chr68085455480854678E08144541
chr68085480880854908E08144795
chr68085495980855036E08144946
chr68081734580817622E0827332
chr68085302180853694E08243008
chr68085381380853863E08243800
chr68085402180854071E08244008
chr68085455480854678E08244541
chr68085480880854908E08244795
chr68085495980855036E08244946










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr68081586280816976E0675849
chr68081586280816976E0685849
chr68081710980817165E0687096
chr68081586280816976E0695849
chr68081586280816976E0705849
chr68081586280816976E0715849
chr68081710980817165E0717096
chr68081586280816976E0725849
chr68081710980817165E0727096
chr68081586280816976E0735849
chr68081710980817165E0737096
chr68081586280816976E0745849
chr68081710980817165E0747096
chr68081586280816976E0815849
chr68081586280816976E0825849