rs745414

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0198 (5767/29118,TOPMED)
A=0232 (6320/27180,GnomAD)
A=0251 (1259/5008,1000G)

Position: chr19:3974967 (GRCh38.p7) (19p13.3)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 302 Enhancers around

Promoter: 36 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 19	NC_000019.10:g.3974967G>A
GRCh37.p13 chr 19	NC_000019.9:g.3974965G>A
EEF2 RefSeqGene	NG_042274.1:g.15497C>T

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.977	A=0.023
1000Genomes	American	Sub	694	G=0.780	A=0.220
1000Genomes	East Asian	Sub	1008	G=0.398	A=0.602
1000Genomes	Europe	Sub	1006	G=0.738	A=0.262
1000Genomes	Global	Study-wide	5008	G=0.749	A=0.251
1000Genomes	South Asian	Sub	978	G=0.790	A=0.210
The Genome Aggregation Database	African	Sub	7896	G=0.934	A=0.066
The Genome Aggregation Database	American	Sub	784	G=0.770	A=0.230
The Genome Aggregation Database	East Asian	Sub	1362	G=0.403	A=0.597
The Genome Aggregation Database	Europe	Sub	16860	G=0.718	A=0.281
The Genome Aggregation Database	Global	Study-wide	27180	G=0.767	A=0.232
The Genome Aggregation Database	Other	Sub	278	G=0.770	A=0.230
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.801	A=0.198

PMID	Title	Author	Journal
21314694	Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.	Kendler KS	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs745414	9.65E-05	alcohol dependence	21314694

eQTL of rs745414 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs745414 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr19	3988182	3988253	E067	13217
chr19	3988289	3988598	E067	13324
chr19	4009310	4009385	E067	34345
chr19	4009411	4009778	E067	34446
chr19	4009793	4009853	E067	34828
chr19	4009862	4009902	E067	34897
chr19	4009917	4010574	E067	34952
chr19	4010672	4010814	E067	35707
chr19	4010895	4011242	E067	35930
chr19	4011281	4011354	E067	36316
chr19	4011439	4011496	E067	36474
chr19	4011546	4011673	E067	36581
chr19	4012145	4012610	E067	37180
chr19	4012920	4013037	E067	37955
chr19	4013232	4013334	E067	38267
chr19	4013630	4013680	E067	38665
chr19	4013761	4013846	E067	38796
chr19	4013889	4013961	E067	38924
chr19	4013986	4014050	E067	39021
chr19	4014119	4014204	E067	39154
chr19	4014294	4014631	E067	39329
chr19	4014724	4015525	E067	39759
chr19	4015583	4016174	E067	40618
chr19	4016240	4016327	E067	41275
chr19	4016392	4016504	E067	41427
chr19	4016533	4016600	E067	41568
chr19	4016652	4016789	E067	41687
chr19	4016963	4017017	E067	41998
chr19	4017086	4017153	E067	42121
chr19	4017233	4017283	E067	42268
chr19	4017307	4017382	E067	42342
chr19	4017478	4017532	E067	42513
chr19	4017588	4017643	E067	42623
chr19	4017716	4017824	E067	42751
chr19	4017982	4018026	E067	43017
chr19	4018363	4018449	E067	43398
chr19	4018588	4018680	E067	43623
chr19	4018979	4019029	E067	44014
chr19	4019051	4019095	E067	44086
chr19	4019252	4019292	E067	44287
chr19	4019467	4019562	E067	44502
chr19	4019648	4019736	E067	44683
chr19	4019748	4019972	E067	44783
chr19	4020216	4020270	E067	45251
chr19	4020293	4020409	E067	45328
chr19	4020494	4020539	E067	45529
chr19	4020705	4020745	E067	45740
chr19	4009917	4010574	E068	34952
chr19	4010672	4010814	E068	35707
chr19	4010895	4011242	E068	35930
chr19	4011281	4011354	E068	36316
chr19	4011439	4011496	E068	36474
chr19	4011546	4011673	E068	36581
chr19	4012145	4012610	E068	37180
chr19	4012920	4013037	E068	37955
chr19	4013232	4013334	E068	38267
chr19	4013630	4013680	E068	38665
chr19	4013761	4013846	E068	38796
chr19	4013889	4013961	E068	38924
chr19	4013986	4014050	E068	39021
chr19	4014119	4014204	E068	39154
chr19	4014294	4014631	E068	39329
chr19	4014724	4015525	E068	39759
chr19	4015583	4016174	E068	40618
chr19	4016240	4016327	E068	41275
chr19	4016392	4016504	E068	41427
chr19	4016533	4016600	E068	41568
chr19	4016652	4016789	E068	41687
chr19	4016963	4017017	E068	41998
chr19	4017086	4017153	E068	42121
chr19	4017233	4017283	E068	42268
chr19	4017307	4017382	E068	42342
chr19	4018363	4018449	E068	43398
chr19	4018588	4018680	E068	43623
chr19	4018979	4019029	E068	44014
chr19	4019051	4019095	E068	44086
chr19	4019252	4019292	E068	44287
chr19	4019467	4019562	E068	44502
chr19	4019648	4019736	E068	44683
chr19	4019748	4019972	E068	44783
chr19	4020216	4020270	E068	45251
chr19	4020293	4020409	E068	45328
chr19	4020494	4020539	E068	45529
chr19	4020705	4020745	E068	45740
chr19	4009411	4009778	E069	34446
chr19	4010672	4010814	E069	35707
chr19	4010895	4011242	E069	35930
chr19	4011281	4011354	E069	36316
chr19	4011439	4011496	E069	36474
chr19	4011546	4011673	E069	36581
chr19	4012145	4012610	E069	37180
chr19	4012920	4013037	E069	37955
chr19	4013232	4013334	E069	38267
chr19	4013630	4013680	E069	38665
chr19	4013761	4013846	E069	38796
chr19	4013889	4013961	E069	38924
chr19	4013986	4014050	E069	39021
chr19	4014724	4015525	E069	39759
chr19	4015583	4016174	E069	40618
chr19	4016652	4016789	E069	41687
chr19	4016963	4017017	E069	41998
chr19	4017086	4017153	E069	42121
chr19	4017233	4017283	E069	42268
chr19	4017307	4017382	E069	42342
chr19	4017478	4017532	E069	42513
chr19	4017588	4017643	E069	42623
chr19	4017716	4017824	E069	42751
chr19	4017982	4018026	E069	43017
chr19	4018979	4019029	E069	44014
chr19	4019051	4019095	E069	44086
chr19	4019252	4019292	E069	44287
chr19	4019467	4019562	E069	44502
chr19	4019648	4019736	E069	44683
chr19	4019748	4019972	E069	44783
chr19	4020216	4020270	E069	45251
chr19	4020293	4020409	E069	45328
chr19	4020494	4020539	E069	45529
chr19	4020705	4020745	E069	45740
chr19	3968140	3968249	E070	-6716
chr19	4009411	4009778	E070	34446
chr19	4009793	4009853	E070	34828
chr19	4009862	4009902	E070	34897
chr19	4009917	4010574	E070	34952
chr19	4010672	4010814	E070	35707
chr19	4010895	4011242	E070	35930
chr19	4011281	4011354	E070	36316
chr19	4011439	4011496	E070	36474
chr19	4011546	4011673	E070	36581
chr19	4013761	4013846	E070	38796
chr19	4013889	4013961	E070	38924
chr19	4013986	4014050	E070	39021
chr19	4014119	4014204	E070	39154
chr19	4009411	4009778	E071	34446
chr19	4010672	4010814	E071	35707
chr19	4010895	4011242	E071	35930
chr19	4011281	4011354	E071	36316
chr19	4011439	4011496	E071	36474
chr19	4011546	4011673	E071	36581
chr19	4012145	4012610	E071	37180
chr19	4012920	4013037	E071	37955
chr19	4013232	4013334	E071	38267
chr19	4013630	4013680	E071	38665
chr19	4013761	4013846	E071	38796
chr19	4013889	4013961	E071	38924
chr19	4013986	4014050	E071	39021
chr19	4014119	4014204	E071	39154
chr19	4014294	4014631	E071	39329
chr19	4014724	4015525	E071	39759
chr19	4015583	4016174	E071	40618
chr19	4016240	4016327	E071	41275
chr19	4017233	4017283	E071	42268
chr19	4017307	4017382	E071	42342
chr19	4017478	4017532	E071	42513
chr19	4017588	4017643	E071	42623
chr19	4017716	4017824	E071	42751
chr19	4017982	4018026	E071	43017
chr19	4018363	4018449	E071	43398
chr19	4018588	4018680	E071	43623
chr19	4018979	4019029	E071	44014
chr19	4019051	4019095	E071	44086
chr19	4019252	4019292	E071	44287
chr19	4019467	4019562	E071	44502
chr19	4019648	4019736	E071	44683
chr19	4019748	4019972	E071	44783
chr19	4020216	4020270	E071	45251
chr19	4020293	4020409	E071	45328
chr19	4020494	4020539	E071	45529
chr19	4020705	4020745	E071	45740
chr19	3965992	3967021	E072	-7944
chr19	3988182	3988253	E072	13217
chr19	3988289	3988598	E072	13324
chr19	4009411	4009778	E072	34446
chr19	4010672	4010814	E072	35707
chr19	4010895	4011242	E072	35930
chr19	4011281	4011354	E072	36316
chr19	4011439	4011496	E072	36474
chr19	4011546	4011673	E072	36581
chr19	4012145	4012610	E072	37180
chr19	4012920	4013037	E072	37955
chr19	4013232	4013334	E072	38267
chr19	4013630	4013680	E072	38665
chr19	4013761	4013846	E072	38796
chr19	4013889	4013961	E072	38924
chr19	4013986	4014050	E072	39021
chr19	4014119	4014204	E072	39154
chr19	4014294	4014631	E072	39329
chr19	4014724	4015525	E072	39759
chr19	4015583	4016174	E072	40618
chr19	4017588	4017643	E072	42623
chr19	4017716	4017824	E072	42751
chr19	4017982	4018026	E072	43017
chr19	4018979	4019029	E072	44014
chr19	4019051	4019095	E072	44086
chr19	4019252	4019292	E072	44287
chr19	4019467	4019562	E072	44502
chr19	4019648	4019736	E072	44683
chr19	4019748	4019972	E072	44783
chr19	4020216	4020270	E072	45251
chr19	4020293	4020409	E072	45328
chr19	4020494	4020539	E072	45529
chr19	4020705	4020745	E072	45740
chr19	3980875	3980971	E073	5910
chr19	3980998	3981228	E073	6033
chr19	3981235	3981546	E073	6270
chr19	3981908	3982666	E073	6943
chr19	3982676	3982763	E073	7711
chr19	4011439	4011496	E073	36474
chr19	4011546	4011673	E073	36581
chr19	4012145	4012610	E073	37180
chr19	4012920	4013037	E073	37955
chr19	4013232	4013334	E073	38267
chr19	4013630	4013680	E073	38665
chr19	4013761	4013846	E073	38796
chr19	4013889	4013961	E073	38924
chr19	4013986	4014050	E073	39021
chr19	4014119	4014204	E073	39154
chr19	4014294	4014631	E073	39329
chr19	4014724	4015525	E073	39759
chr19	4016652	4016789	E073	41687
chr19	4016963	4017017	E073	41998
chr19	4017086	4017153	E073	42121
chr19	4017233	4017283	E073	42268
chr19	4017307	4017382	E073	42342
chr19	4017478	4017532	E073	42513
chr19	4017588	4017643	E073	42623
chr19	4018363	4018449	E073	43398
chr19	4018588	4018680	E073	43623
chr19	4018979	4019029	E073	44014
chr19	4019051	4019095	E073	44086
chr19	4019252	4019292	E073	44287
chr19	4019467	4019562	E073	44502
chr19	4019648	4019736	E073	44683
chr19	4019748	4019972	E073	44783
chr19	4020216	4020270	E073	45251
chr19	4020293	4020409	E073	45328
chr19	4020494	4020539	E073	45529
chr19	4020705	4020745	E073	45740
chr19	3988182	3988253	E074	13217
chr19	3988289	3988598	E074	13324
chr19	4009310	4009385	E074	34345
chr19	4009411	4009778	E074	34446
chr19	4009793	4009853	E074	34828
chr19	4009862	4009902	E074	34897
chr19	4009917	4010574	E074	34952
chr19	4010672	4010814	E074	35707
chr19	4010895	4011242	E074	35930
chr19	4011281	4011354	E074	36316
chr19	4011439	4011496	E074	36474
chr19	4011546	4011673	E074	36581
chr19	4012145	4012610	E074	37180
chr19	4012920	4013037	E074	37955
chr19	4013232	4013334	E074	38267
chr19	4013630	4013680	E074	38665
chr19	4013761	4013846	E074	38796
chr19	4013889	4013961	E074	38924
chr19	4013986	4014050	E074	39021
chr19	4014119	4014204	E074	39154
chr19	4014294	4014631	E074	39329
chr19	4014724	4015525	E074	39759
chr19	4015583	4016174	E074	40618
chr19	4016240	4016327	E074	41275
chr19	4016392	4016504	E074	41427
chr19	4016652	4016789	E074	41687
chr19	4016963	4017017	E074	41998
chr19	4017233	4017283	E074	42268
chr19	4017307	4017382	E074	42342
chr19	4017588	4017643	E074	42623
chr19	4017716	4017824	E074	42751
chr19	4017982	4018026	E074	43017
chr19	4018363	4018449	E074	43398
chr19	4018588	4018680	E074	43623
chr19	4018979	4019029	E074	44014
chr19	4019051	4019095	E074	44086
chr19	4019252	4019292	E074	44287
chr19	4019467	4019562	E074	44502
chr19	4019648	4019736	E074	44683
chr19	4019748	4019972	E074	44783
chr19	4020216	4020270	E074	45251
chr19	4020293	4020409	E074	45328
chr19	4020494	4020539	E074	45529
chr19	3988182	3988253	E081	13217
chr19	3988289	3988598	E081	13324
chr19	4009310	4009385	E081	34345
chr19	4009411	4009778	E081	34446
chr19	4009793	4009853	E081	34828
chr19	4009862	4009902	E081	34897
chr19	4009917	4010574	E081	34952
chr19	4010672	4010814	E081	35707
chr19	4010895	4011242	E081	35930
chr19	4011281	4011354	E081	36316
chr19	4011439	4011496	E081	36474
chr19	4011546	4011673	E081	36581
chr19	4017588	4017643	E081	42623
chr19	4017716	4017824	E081	42751
chr19	4017982	4018026	E081	43017
chr19	4018363	4018449	E081	43398
chr19	4018588	4018680	E081	43623
chr19	4018979	4019029	E081	44014
chr19	4019051	4019095	E081	44086
chr19	4019252	4019292	E081	44287
chr19	4018363	4018449	E082	43398
chr19	4018588	4018680	E082	43623

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr19	3982815	3987262	E067	7850
chr19	3989769	3989826	E067	14804
chr19	3989861	3990588	E067	14896
chr19	4006725	4008916	E067	31760
chr19	3982815	3987262	E068	7850
chr19	3989769	3989826	E068	14804
chr19	3989861	3990588	E068	14896
chr19	4006725	4008916	E068	31760
chr19	3982815	3987262	E069	7850
chr19	3989769	3989826	E069	14804
chr19	3989861	3990588	E069	14896
chr19	4006725	4008916	E069	31760
chr19	3982815	3987262	E070	7850
chr19	3989769	3989826	E070	14804
chr19	3989861	3990588	E070	14896
chr19	4006725	4008916	E070	31760
chr19	3982815	3987262	E071	7850
chr19	3989769	3989826	E071	14804
chr19	3989861	3990588	E071	14896
chr19	4006725	4008916	E071	31760
chr19	3982815	3987262	E072	7850
chr19	3989769	3989826	E072	14804
chr19	3989861	3990588	E072	14896
chr19	4006725	4008916	E072	31760
chr19	3989769	3989826	E073	14804
chr19	3989861	3990588	E073	14896
chr19	4006725	4008916	E073	31760
chr19	3989769	3989826	E074	14804
chr19	3989861	3990588	E074	14896
chr19	4006725	4008916	E074	31760
chr19	3982815	3987262	E081	7850
chr19	3989861	3990588	E081	14896
chr19	3982815	3987262	E082	7850
chr19	3989769	3989826	E082	14804
chr19	3989861	3990588	E082	14896
chr19	4006725	4008916	E082	31760