rs745884

Homo sapiens
C>A / C>G / C>T
None
Check p-value
SNV (Single Nucleotide Variation)
A=0248 (7431/29908,GnomAD)
A=0209 (6112/29116,TOPMED)
A=0285 (1429/5008,1000G)
A=0287 (1108/3854,ALSPAC)
A=0273 (1012/3708,TWINSUK)
chr2:119151809 (GRCh38.p7) (2q14.2)
CD
GWASdb2
1   publication(s)
See rs on genome
21 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.119151809C>A
GRCh38.p7 chr 2NC_000002.12:g.119151809C>G
GRCh38.p7 chr 2NC_000002.12:g.119151809C>T
GRCh37.p13 chr 2NC_000002.11:g.119909385C>A
GRCh37.p13 chr 2NC_000002.11:g.119909385C>G
GRCh37.p13 chr 2NC_000002.11:g.119909385C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.958A=0.042
1000GenomesAmericanSub694C=0.800A=0.200
1000GenomesEast AsianSub1008C=0.394A=0.606
1000GenomesEuropeSub1006C=0.692A=0.308
1000GenomesGlobalStudy-wide5008C=0.715A=0.285
1000GenomesSouth AsianSub978C=0.680A=0.320
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.713A=0.287
The Genome Aggregation DatabaseAfricanSub8710C=0.910G=0.001
The Genome Aggregation DatabaseAmericanSub838C=0.770G=0.00,
The Genome Aggregation DatabaseEast AsianSub1616C=0.420G=0.000
The Genome Aggregation DatabaseEuropeSub18442C=0.705G=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29908C=0.751G=0.000
The Genome Aggregation DatabaseOtherSub302C=0.670G=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29116C=0.790A=0.209
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.727A=0.273
PMID Title Author Journal
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs7458843.74E-05cocaine dependence23958962

eQTL of rs745884 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs745884 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr264775676477816E070-47944
chr264857026485984E070-39776
chr264987626498967E070-26793
chr264993036499384E070-26376
chr264996086499855E070-25905
chr265001736500333E070-25427
chr265110126511120E071-14640
chr265110126511120E074-14640
chr264987626498967E081-26793
chr264993036499384E081-26376
chr264996086499855E081-25905
chr265001736500333E081-25427
chr265638266564093E08138066
chr265642166564384E08138456
chr265645436564611E08138783
chr264985106498603E082-27157
chr264987626498967E082-26793
chr264993036499384E082-26376
chr265613786561428E08235618
chr265638266564093E08238066
chr265642166564384E08238456