rs745888

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0248 (7447/29958,GnomAD)
T=0210 (6115/29116,TOPMED)
T=0285 (1427/5008,1000G)
T=0287 (1107/3854,ALSPAC)
T=0273 (1012/3708,TWINSUK)
chr2:119152738 (GRCh38.p7) (2q14.2)
CD
GWASdb2
1   publication(s)
See rs on genome
23 Enhancers around
36 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.119152738C>T
GRCh37.p13 chr 2NC_000002.11:g.119910314C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.959T=0.041
1000GenomesAmericanSub694C=0.800T=0.200
1000GenomesEast AsianSub1008C=0.395T=0.605
1000GenomesEuropeSub1006C=0.692T=0.308
1000GenomesGlobalStudy-wide5008C=0.715T=0.285
1000GenomesSouth AsianSub978C=0.680T=0.320
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.713T=0.287
The Genome Aggregation DatabaseAfricanSub8720C=0.911T=0.089
The Genome Aggregation DatabaseAmericanSub838C=0.770T=0.230
The Genome Aggregation DatabaseEast AsianSub1616C=0.420T=0.580
The Genome Aggregation DatabaseEuropeSub18482C=0.705T=0.294
The Genome Aggregation DatabaseGlobalStudy-wide29958C=0.751T=0.248
The Genome Aggregation DatabaseOtherSub302C=0.670T=0.330
Trans-Omics for Precision MedicineGlobalStudy-wide29116C=0.790T=0.210
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.727T=0.273
PMID Title Author Journal
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs7458886.3E-05cocaine dependence23958962

eQTL of rs745888 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs745888 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2119900443119900910E067-9404
chr2119900443119900910E069-9404
chr2119875909119876048E070-34266
chr2119876648119876856E070-33458
chr2119876894119876962E070-33352
chr2119877091119877197E070-33117
chr2119881052119881172E070-29142
chr2119892743119892793E070-17521
chr2119900443119900910E070-9404
chr2119938620119938679E07028306
chr2119902369119902629E071-7685
chr2119900443119900910E074-9404
chr2119900443119900910E081-9404
chr2119938620119938679E08128306
chr2119939320119939383E08129006
chr2119939461119939758E08129147
chr2119941373119941439E08131059
chr2119877091119877197E082-33117
chr2119897447119897517E082-12797
chr2119897682119897732E082-12582
chr2119938620119938679E08228306
chr2119939320119939383E08229006
chr2119939461119939758E08229147







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr2119915979119916029E0675665
chr2119916179119916577E0675865
chr2119915810119915936E0685496
chr2119915979119916029E0685665
chr2119916179119916577E0685865
chr2119914353119914622E0694039
chr2119914659119914801E0694345
chr2119914954119915097E0694640
chr2119915163119915277E0694849
chr2119915979119916029E0695665
chr2119916179119916577E0695865
chr2119914954119915097E0704640
chr2119915163119915277E0704849
chr2119915810119915936E0705496
chr2119914954119915097E0714640
chr2119915810119915936E0715496
chr2119915979119916029E0715665
chr2119916179119916577E0715865
chr2119914353119914622E0724039
chr2119914659119914801E0724345
chr2119914954119915097E0724640
chr2119915163119915277E0724849
chr2119915810119915936E0725496
chr2119915979119916029E0725665
chr2119916179119916577E0725865
chr2119914954119915097E0734640
chr2119915163119915277E0734849
chr2119915810119915936E0735496
chr2119915979119916029E0735665
chr2119916179119916577E0735865
chr2119914659119914801E0824345
chr2119914954119915097E0824640
chr2119915163119915277E0824849
chr2119915810119915936E0825496
chr2119915979119916029E0825665
chr2119916179119916577E0825865