rs746215

Homo sapiens
T>C
LOC285593 : Non Coding Transcript Variant
LOC105377735 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0175 (5261/29942,GnomAD)
C=0150 (4377/29118,TOPMED)
C=0137 (685/5008,1000G)
C=0221 (853/3854,ALSPAC)
C=0209 (775/3708,TWINSUK)
chr5:173584350 (GRCh38.p7) (5q35.2)
AD
GWASdb2
1   publication(s)
See rs on genome
210 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.173584350T>C
GRCh37.p13 chr 5NC_000005.9:g.173011353T>C

Gene: LOC285593, uncharacterized LOC285593(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC285593 transcript variant 1NR_027108.2:n.106...NR_027108.2:n.1068T>CT>CNon Coding Transcript Variant
LOC285593 transcript variant 2NR_027109.2:n.N/AGenic Downstream Transcript Variant

Gene: LOC105377735, uncharacterized LOC105377735(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105377735 transcriptXR_941250.2:n.114A>GA>GNon Coding Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.955C=0.045
1000GenomesAmericanSub694T=0.860C=0.140
1000GenomesEast AsianSub1008T=0.874C=0.126
1000GenomesEuropeSub1006T=0.770C=0.230
1000GenomesGlobalStudy-wide5008T=0.863C=0.137
1000GenomesSouth AsianSub978T=0.830C=0.170
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.779C=0.221
The Genome Aggregation DatabaseAfricanSub8722T=0.935C=0.065
The Genome Aggregation DatabaseAmericanSub838T=0.820C=0.180
The Genome Aggregation DatabaseEast AsianSub1618T=0.902C=0.098
The Genome Aggregation DatabaseEuropeSub18462T=0.765C=0.234
The Genome Aggregation DatabaseGlobalStudy-wide29942T=0.824C=0.175
The Genome Aggregation DatabaseOtherSub302T=0.800C=0.200
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.849C=0.150
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.791C=0.209
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs7462150.000905alcohol dependence24277619

eQTL of rs746215 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr5:173011353CTB-33O18.3ENSG00000253955.1T>C1.7005e-44707Caudate_basal_ganglia

meQTL of rs746215 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5172981014172981262E067-30091
chr5172982396172982694E067-28659
chr5172983515172983686E067-27667
chr5172983799172983970E067-27383
chr5172984279172984501E067-26852
chr5172984641172984782E067-26571
chr5172998764172998845E067-12508
chr5172999165172999351E067-12002
chr5172999609172999744E067-11609
chr5172999989173000457E067-10896
chr5173031965173032015E06720612
chr5173039557173039637E06728204
chr5173044366173044492E06733013
chr5173045550173045651E06734197
chr5173045720173045833E06734367
chr5173045886173045975E06734533
chr5173046017173046349E06734664
chr5173046385173046476E06735032
chr5173046654173046747E06735301
chr5173052411173052545E06741058
chr5173052614173052959E06741261
chr5173053057173053228E06741704
chr5173053232173053329E06741879
chr5173053566173053648E06742213
chr5173053836173053903E06742483
chr5173054837173055697E06743484
chr5173055742173055811E06744389
chr5173057598173057648E06746245
chr5173057670173058054E06746317
chr5172981014172981262E068-30091
chr5172982396172982694E068-28659
chr5172983515172983686E068-27667
chr5172983799172983970E068-27383
chr5172984279172984501E068-26852
chr5172984641172984782E068-26571
chr5172999609172999744E068-11609
chr5172999989173000457E068-10896
chr5173025684173025748E06814331
chr5173025809173025921E06814456
chr5173025975173026222E06814622
chr5173031148173031280E06819795
chr5173031965173032015E06820612
chr5173039557173039637E06828204
chr5173040111173040252E06828758
chr5173040332173040690E06828979
chr5173044366173044492E06833013
chr5173051920173052027E06840567
chr5173052411173052545E06841058
chr5173052614173052959E06841261
chr5173053057173053228E06841704
chr5173053232173053329E06841879
chr5173053566173053648E06842213
chr5173053836173053903E06842483
chr5173054837173055697E06843484
chr5173055742173055811E06844389
chr5173056112173056200E06844759
chr5173056420173056460E06845067
chr5173056565173056765E06845212
chr5173056802173056962E06845449
chr5172981014172981262E069-30091
chr5172982396172982694E069-28659
chr5172983515172983686E069-27667
chr5172983799172983970E069-27383
chr5173017532173017637E0696179
chr5173017697173017747E0696344
chr5173017750173018316E0696397
chr5173018332173018549E0696979
chr5173029541173029766E06918188
chr5173031148173031280E06919795
chr5173040111173040252E06928758
chr5173040332173040690E06928979
chr5173044366173044492E06933013
chr5173045886173045975E06934533
chr5173046017173046349E06934664
chr5173052411173052545E06941058
chr5173052614173052959E06941261
chr5173053566173053648E06942213
chr5173054837173055697E06943484
chr5173055742173055811E06944389
chr5173056112173056200E06944759
chr5173056420173056460E06945067
chr5173056565173056765E06945212
chr5173056802173056962E06945449
chr5173057598173057648E06946245
chr5173057670173058054E06946317
chr5172981014172981262E070-30091
chr5172982396172982694E070-28659
chr5172983515172983686E070-27667
chr5172983799172983970E070-27383
chr5172984279172984501E070-26852
chr5172984641172984782E070-26571
chr5173044366173044492E07033013
chr5173052614173052959E07041261
chr5173053057173053228E07041704
chr5173054837173055697E07043484
chr5173057598173057648E07046245
chr5173057670173058054E07046317
chr5172981014172981262E071-30091
chr5172982396172982694E071-28659
chr5172983515172983686E071-27667
chr5172983799172983970E071-27383
chr5172984279172984501E071-26852
chr5172984641172984782E071-26571
chr5172999609172999744E071-11609
chr5173017750173018316E0716397
chr5173018332173018549E0716979
chr5173025809173025921E07114456
chr5173025975173026222E07114622
chr5173031148173031280E07119795
chr5173044617173044823E07133264
chr5173046017173046349E07134664
chr5173046385173046476E07135032
chr5173052411173052545E07141058
chr5173052614173052959E07141261
chr5173053232173053329E07141879
chr5173053566173053648E07142213
chr5173053836173053903E07142483
chr5173054837173055697E07143484
chr5173055742173055811E07144389
chr5173056112173056200E07144759
chr5173056420173056460E07145067
chr5173056565173056765E07145212
chr5173056802173056962E07145449
chr5173057598173057648E07146245
chr5173057670173058054E07146317
chr5172981014172981262E072-30091
chr5172982396172982694E072-28659
chr5172983515172983686E072-27667
chr5172983799172983970E072-27383
chr5172984279172984501E072-26852
chr5172984641172984782E072-26571
chr5172999609172999744E072-11609
chr5172999989173000457E072-10896
chr5173000549173000594E072-10759
chr5173017750173018316E0726397
chr5173018332173018549E0726979
chr5173025809173025921E07214456
chr5173031148173031280E07219795
chr5173044366173044492E07233013
chr5173044617173044823E07233264
chr5173051920173052027E07240567
chr5173052411173052545E07241058
chr5173053232173053329E07241879
chr5173053566173053648E07242213
chr5173054837173055697E07243484
chr5173055742173055811E07244389
chr5173056802173056962E07245449
chr5173057598173057648E07246245
chr5172981014172981262E073-30091
chr5172983515172983686E073-27667
chr5172983799172983970E073-27383
chr5173025684173025748E07314331
chr5173025809173025921E07314456
chr5173025975173026222E07314622
chr5173044366173044492E07333013
chr5173052411173052545E07341058
chr5173052614173052959E07341261
chr5173053057173053228E07341704
chr5173053232173053329E07341879
chr5173053566173053648E07342213
chr5173053836173053903E07342483
chr5173054837173055697E07343484
chr5173055742173055811E07344389
chr5173056112173056200E07344759
chr5173056420173056460E07345067
chr5173056565173056765E07345212
chr5173056802173056962E07345449
chr5173057598173057648E07346245
chr5173057670173058054E07346317
chr5172981014172981262E074-30091
chr5172982396172982694E074-28659
chr5172983515172983686E074-27667
chr5172983799172983970E074-27383
chr5172984279172984501E074-26852
chr5172984641172984782E074-26571
chr5172999609172999744E074-11609
chr5173029541173029766E07418188
chr5173031148173031280E07419795
chr5173044366173044492E07433013
chr5173052614173052959E07441261
chr5173053057173053228E07441704
chr5173053232173053329E07441879
chr5173053566173053648E07442213
chr5173053836173053903E07442483
chr5173054837173055697E07443484
chr5173055742173055811E07444389
chr5173056112173056200E07444759
chr5173056420173056460E07445067
chr5173056565173056765E07445212
chr5173056802173056962E07445449
chr5173057598173057648E07446245
chr5172982396172982694E081-28659
chr5173039557173039637E08128204
chr5173039831173039916E08128478
chr5173040111173040252E08128758
chr5173040332173040690E08128979
chr5173054837173055697E08143484
chr5173055742173055811E08144389
chr5173056112173056200E08144759
chr5173056420173056460E08145067
chr5173056565173056765E08145212
chr5173056802173056962E08145449
chr5173057598173057648E08146245
chr5173057670173058054E08146317
chr5173040332173040690E08228979
chr5173052614173052959E08241261
chr5173054837173055697E08243484
chr5173056802173056962E08245449
chr5173057598173057648E08246245
chr5173057670173058054E08246317










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr5173042799173044150E06731446
chr5173042799173044150E06831446
chr5173042799173044150E06931446
chr5173042799173044150E07031446
chr5173042799173044150E07131446
chr5173042799173044150E07231446
chr5173042799173044150E07331446
chr5173042799173044150E07431446
chr5173042799173044150E08231446