rs74676837

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0029 (892/29976,GnomAD)
G=0038 (1114/29118,TOPMED)
G=0030 (151/5008,1000G)
G=0025 (98/3854,ALSPAC)
G=0028 (103/3708,TWINSUK)
chr8:130446408 (GRCh38.p7) (8q24.22)
CD
GWASdb2
1   publication(s)
See rs on genome
164 Enhancers around
6 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.130446408A>G
GRCh37.p13 chr 8NC_000008.10:g.131458654A>G
ASAP1 RefSeqGeneNG_030354.1:g.2253T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.936G=0.064
1000GenomesAmericanSub694A=0.970G=0.030
1000GenomesEast AsianSub1008A=0.999G=0.001
1000GenomesEuropeSub1006A=0.962G=0.038
1000GenomesGlobalStudy-wide5008A=0.970G=0.030
1000GenomesSouth AsianSub978A=0.990G=0.010
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.975G=0.025
The Genome Aggregation DatabaseAfricanSub8720A=0.944G=0.056
The Genome Aggregation DatabaseAmericanSub838A=0.980G=0.020
The Genome Aggregation DatabaseEast AsianSub1622A=0.999G=0.001
The Genome Aggregation DatabaseEuropeSub18494A=0.979G=0.020
The Genome Aggregation DatabaseGlobalStudy-wide29976A=0.970G=0.029
The Genome Aggregation DatabaseOtherSub302A=0.970G=0.030
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.961G=0.038
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.972G=0.028
PMID Title Author Journal
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs746768374.18E-05cocaine dependence23958962

eQTL of rs74676837 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs74676837 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr8131451909131452477E067-6177
chr8131452815131452855E067-5799
chr8131452951131453011E067-5643
chr8131453159131453497E067-5157
chr8131453517131453576E067-5078
chr8131501666131501716E06743012
chr8131501959131502157E06743305
chr8131428073131428812E068-29842
chr8131428817131429156E068-29498
chr8131429220131429527E068-29127
chr8131429556131429744E068-28910
chr8131449600131449650E068-9004
chr8131449723131449829E068-8825
chr8131449867131451143E068-7511
chr8131452815131452855E068-5799
chr8131452951131453011E068-5643
chr8131453159131453497E068-5157
chr8131453517131453576E068-5078
chr8131475677131475848E06817023
chr8131475861131475971E06817207
chr8131476015131476106E06817361
chr8131476156131476631E06817502
chr8131476641131477148E06817987
chr8131477854131478479E06819200
chr8131501500131501599E06842846
chr8131503407131504300E06844753
chr8131504328131504508E06845674
chr8131504511131504561E06845857
chr8131504572131504622E06845918
chr8131504661131504837E06846007
chr8131505692131505742E06847038
chr8131428073131428812E069-29842
chr8131431253131432163E069-26491
chr8131442855131442948E069-15706
chr8131443074131443438E069-15216
chr8131443567131443650E069-15004
chr8131452815131452855E069-5799
chr8131452951131453011E069-5643
chr8131453159131453497E069-5157
chr8131453517131453576E069-5078
chr8131476156131476631E06917502
chr8131476641131477148E06917987
chr8131414665131414719E070-43935
chr8131415012131415066E070-43588
chr8131423899131424057E070-34597
chr8131424102131424177E070-34477
chr8131424298131424348E070-34306
chr8131427375131427460E070-31194
chr8131428817131429156E070-29498
chr8131429770131430277E070-28377
chr8131430386131430478E070-28176
chr8131431253131432163E070-26491
chr8131449867131451143E070-7511
chr8131451171131451272E070-7382
chr8131451357131451431E070-7223
chr8131451436131451505E070-7149
chr8131451661131451727E070-6927
chr8131451749131451889E070-6765
chr8131451909131452477E070-6177
chr8131458284131458324E070-330
chr8131458365131458644E070-10
chr8131465726131466175E0707072
chr8131468858131468978E07010204
chr8131469507131469570E07010853
chr8131469647131469989E07010993
chr8131470016131470160E07011362
chr8131470269131470329E07011615
chr8131475677131475848E07017023
chr8131475861131475971E07017207
chr8131476015131476106E07017361
chr8131476156131476631E07017502
chr8131480443131480527E07021789
chr8131480980131481083E07022326
chr8131481272131481322E07022618
chr8131481558131481648E07022904
chr8131482107131482186E07023453
chr8131504511131504561E07045857
chr8131504572131504622E07045918
chr8131504661131504837E07046007
chr8131504847131504920E07046193
chr8131505126131505330E07046472
chr8131505365131505430E07046711
chr8131505457131505507E07046803
chr8131505519131505569E07046865
chr8131505692131505742E07047038
chr8131428073131428812E071-29842
chr8131428817131429156E071-29498
chr8131429220131429527E071-29127
chr8131449474131449597E071-9057
chr8131449600131449650E071-9004
chr8131449723131449829E071-8825
chr8131449867131451143E071-7511
chr8131452951131453011E071-5643
chr8131453159131453497E071-5157
chr8131453517131453576E071-5078
chr8131428817131429156E072-29498
chr8131431095131431252E072-27402
chr8131431253131432163E072-26491
chr8131449867131451143E072-7511
chr8131452951131453011E072-5643
chr8131453159131453497E072-5157
chr8131453517131453576E072-5078
chr8131501666131501716E07243012
chr8131501959131502157E07243305
chr8131428817131429156E073-29498
chr8131429220131429527E073-29127
chr8131442570131442642E073-16012
chr8131442855131442948E073-15706
chr8131443074131443438E073-15216
chr8131443567131443650E073-15004
chr8131445007131445087E073-13567
chr8131445230131445373E073-13281
chr8131445380131445437E073-13217
chr8131449867131451143E073-7511
chr8131452815131452855E073-5799
chr8131452951131453011E073-5643
chr8131453159131453497E073-5157
chr8131453517131453576E073-5078
chr8131428817131429156E074-29498
chr8131429220131429527E074-29127
chr8131429556131429744E074-28910
chr8131429770131430277E074-28377
chr8131431253131432163E074-26491
chr8131445380131445437E074-13217
chr8131445658131445920E074-12734
chr8131449474131449597E074-9057
chr8131449867131451143E074-7511
chr8131451171131451272E074-7382
chr8131451357131451431E074-7223
chr8131451436131451505E074-7149
chr8131452815131452855E074-5799
chr8131452951131453011E074-5643
chr8131453159131453497E074-5157
chr8131453517131453576E074-5078
chr8131452815131452855E081-5799
chr8131452951131453011E081-5643
chr8131453159131453497E081-5157
chr8131453517131453576E081-5078
chr8131475076131475305E08116422
chr8131475347131475438E08116693
chr8131475677131475848E08117023
chr8131475861131475971E08117207
chr8131476015131476106E08117361
chr8131476156131476631E08117502
chr8131476641131477148E08117987
chr8131493393131493632E08134739
chr8131428817131429156E082-29498
chr8131429220131429527E082-29127
chr8131451357131451431E082-7223
chr8131451436131451505E082-7149
chr8131451661131451727E082-6927
chr8131451749131451889E082-6765
chr8131451909131452477E082-6177
chr8131452815131452855E082-5799
chr8131452951131453011E082-5643
chr8131475677131475848E08217023
chr8131475861131475971E08217207
chr8131476015131476106E08217361
chr8131476156131476631E08217502
chr8131476641131477148E08217987
chr8131477781131477847E08219127
chr8131477854131478479E08219200
chr8131493393131493632E08234739
chr8131493664131493741E08235010










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr8131453650131457893E067-761
chr8131453650131457893E068-761
chr8131453650131457893E069-761
chr8131453650131457893E070-761
chr8131453650131457893E072-761
chr8131453650131457893E082-761