rs74745534

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0017 (535/29988,GnomAD)
T=0018 (548/29118,TOPMED)
T=0011 (56/5008,1000G)
T=0030 (117/3854,ALSPAC)
T=0032 (119/3708,TWINSUK)
chr6:49589080 (GRCh38.p7) (6p12.3)
AD
GWASCatalog
1   publication(s)
See rs on genome
0 Enhancer around
13 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.49589080C>T
GRCh37.p13 chr 6NC_000006.11:g.49556793C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.995T=0.005
1000GenomesAmericanSub694C=0.980T=0.020
1000GenomesEast AsianSub1008C=1.000T=0.000
1000GenomesEuropeSub1006C=0.968T=0.032
1000GenomesGlobalStudy-wide5008C=0.989T=0.011
1000GenomesSouth AsianSub978C=1.000T=0.000
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.970T=0.030
The Genome Aggregation DatabaseAfricanSub8728C=0.995T=0.005
The Genome Aggregation DatabaseAmericanSub838C=0.990T=0.010
The Genome Aggregation DatabaseEast AsianSub1618C=1.000T=0.000
The Genome Aggregation DatabaseEuropeSub18502C=0.974T=0.025
The Genome Aggregation DatabaseGlobalStudy-wide29988C=0.982T=0.017
The Genome Aggregation DatabaseOtherSub302C=0.960T=0.040
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.981T=0.018
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.968T=0.032
PMID Title Author Journal
26365420The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores.Mbarek HAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs747455341E-06alcohol dependence26365420

eQTL of rs74745534 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs74745534 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr64951776649518800E068-37993
chr64951880849519687E068-37106
chr64951969149519791E068-37002
chr64951776649518800E069-37993
chr64951776649518800E070-37993
chr64951880849519687E071-37106
chr64951880849519687E073-37106
chr64951969149519791E073-37002
chr64951880849519687E074-37106
chr64951969149519791E074-37002
chr64951880849519687E081-37106
chr64951776649518800E082-37993
chr64951880849519687E082-37106