rs7553380

Homo sapiens
A>G / A>T
None
Check p-value
SNV (Single Nucleotide Variation)
G=0087 (2609/29948,GnomAD)
G=0115 (3358/29116,TOPMED)
G=0125 (624/5008,1000G)
G=0047 (183/3854,ALSPAC)
G=0050 (187/3708,TWINSUK)
chr1:220452744 (GRCh38.p7) (1q41)
ND
GWASdb2
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.220452744A>G
GRCh38.p7 chr 1NC_000001.11:g.220452744A>T
GRCh37.p13 chr 1NC_000001.10:g.220626086A>G
GRCh37.p13 chr 1NC_000001.10:g.220626086A>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.793G=0.207
1000GenomesAmericanSub694A=0.950G=0.050
1000GenomesEast AsianSub1008A=0.887G=0.113
1000GenomesEuropeSub1006A=0.948G=0.052
1000GenomesGlobalStudy-wide5008A=0.875G=0.125
1000GenomesSouth AsianSub978A=0.840G=0.160
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.953G=0.047
The Genome Aggregation DatabaseAfricanSub8704A=0.838G=0.162
The Genome Aggregation DatabaseAmericanSub838A=0.960G=0.04,
The Genome Aggregation DatabaseEast AsianSub1614A=0.889G=0.111
The Genome Aggregation DatabaseEuropeSub18490A=0.947G=0.052
The Genome Aggregation DatabaseGlobalStudy-wide29948A=0.912G=0.087
The Genome Aggregation DatabaseOtherSub302A=0.920G=0.08,
Trans-Omics for Precision MedicineGlobalStudy-wide29116A=0.884G=0.115
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.950G=0.050
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs75533805.29E-06alcohol and nictotine co-dependence20158304

eQTL of rs7553380 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7553380 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr14510751745107568E067-47340
chr14510807145108156E067-46752
chr14510855445108685E067-46223
chr14510871045108847E067-46061
chr14510929645109349E067-45559
chr14510958545109639E067-45269
chr14510972645109894E067-45014
chr14511062545110726E067-44182
chr14511083445110899E067-44009
chr14511113045111775E067-43133
chr14511185045111956E067-42952
chr14511199845112215E067-42693
chr14511222145112374E067-42534
chr14511246845112680E067-42228
chr14511499345115043E067-39865
chr14511584745116470E067-38438
chr14511817445118962E067-35946
chr14511902445119149E067-35759
chr14512586645126295E067-28613
chr14512809045128250E067-26658
chr14512843745128689E067-26219
chr14513683845136901E067-18007
chr14513777845138440E067-16468
chr14513847845138719E067-16189
chr14518059945181190E06725691
chr14518285545183659E06727947
chr14510594045106133E068-48775
chr14510751745107568E068-47340
chr14510807145108156E068-46752
chr14510855445108685E068-46223
chr14510871045108847E068-46061
chr14510929645109349E068-45559
chr14510958545109639E068-45269
chr14510972645109894E068-45014
chr14511062545110726E068-44182
chr14511083445110899E068-44009
chr14511113045111775E068-43133
chr14511185045111956E068-42952
chr14511199845112215E068-42693
chr14511584745116470E068-38438
chr14511817445118962E068-35946
chr14512744345128025E068-26883
chr14512809045128250E068-26658
chr14512843745128689E068-26219
chr14513683845136901E068-18007
chr14513777845138440E068-16468
chr14513847845138719E068-16189
chr14514267945142759E068-12149
chr14514276945143222E068-11686
chr14518028845180446E06825380
chr14519480245195282E06839894
chr14519560045195778E06840692
chr14510751745107568E069-47340
chr14510807145108156E069-46752
chr14510855445108685E069-46223
chr14510871045108847E069-46061
chr14510929645109349E069-45559
chr14510958545109639E069-45269
chr14510972645109894E069-45014
chr14511062545110726E069-44182
chr14511083445110899E069-44009
chr14511113045111775E069-43133
chr14511185045111956E069-42952
chr14511199845112215E069-42693
chr14511222145112374E069-42534
chr14511246845112680E069-42228
chr14511348845113634E069-41274
chr14511371745113913E069-40995
chr14511424645114763E069-40145
chr14511485345114931E069-39977
chr14511499345115043E069-39865
chr14511584745116470E069-38438
chr14511817445118962E069-35946
chr14511902445119149E069-35759
chr14513623145136296E069-18612
chr14513683845136901E069-18007
chr14513777845138440E069-16468
chr14513847845138719E069-16189
chr14514122345141277E069-13631
chr14514195145142602E069-12306
chr14514267945142759E069-12149
chr14514276945143222E069-11686
chr14518028845180446E06925380
chr14519577945197284E06940871
chr14512586645126295E070-28613
chr14510594045106133E071-48775
chr14510751745107568E071-47340
chr14510807145108156E071-46752
chr14510855445108685E071-46223
chr14510871045108847E071-46061
chr14510929645109349E071-45559
chr14510958545109639E071-45269
chr14510972645109894E071-45014
chr14511062545110726E071-44182
chr14511083445110899E071-44009
chr14511113045111775E071-43133
chr14511185045111956E071-42952
chr14511199845112215E071-42693
chr14511222145112374E071-42534
chr14511246845112680E071-42228
chr14511348845113634E071-41274
chr14511424645114763E071-40145
chr14511485345114931E071-39977
chr14511499345115043E071-39865
chr14511584745116470E071-38438
chr14511817445118962E071-35946
chr14511902445119149E071-35759
chr14512132845121503E071-33405
chr14512586645126295E071-28613
chr14512744345128025E071-26883
chr14513683845136901E071-18007
chr14513777845138440E071-16468
chr14513847845138719E071-16189
chr14514122345141277E071-13631
chr14517368145173911E07118773
chr14517426445174490E07119356
chr14510751745107568E072-47340
chr14510807145108156E072-46752
chr14510855445108685E072-46223
chr14510871045108847E072-46061
chr14510929645109349E072-45559
chr14510958545109639E072-45269
chr14510972645109894E072-45014
chr14511062545110726E072-44182
chr14511083445110899E072-44009
chr14511113045111775E072-43133
chr14511185045111956E072-42952
chr14511199845112215E072-42693
chr14511222145112374E072-42534
chr14511246845112680E072-42228
chr14511348845113634E072-41274
chr14511371745113913E072-40995
chr14511424645114763E072-40145
chr14511485345114931E072-39977
chr14511499345115043E072-39865
chr14511584745116470E072-38438
chr14511817445118962E072-35946
chr14512132845121503E072-33405
chr14512744345128025E072-26883
chr14512809045128250E072-26658
chr14512843745128689E072-26219
chr14513777845138440E072-16468
chr14513847845138719E072-16189
chr14514276945143222E072-11686
chr14518059945181190E07225691
chr14510751745107568E073-47340
chr14510807145108156E073-46752
chr14510855445108685E073-46223
chr14510871045108847E073-46061
chr14510929645109349E073-45559
chr14510958545109639E073-45269
chr14510972645109894E073-45014
chr14511062545110726E073-44182
chr14511083445110899E073-44009
chr14511113045111775E073-43133
chr14511185045111956E073-42952
chr14511499345115043E073-39865
chr14511584745116470E073-38438
chr14511817445118962E073-35946
chr14512586645126295E073-28613
chr14512744345128025E073-26883
chr14512809045128250E073-26658
chr14512843745128689E073-26219
chr14513683845136901E073-18007
chr14513777845138440E073-16468
chr14513847845138719E073-16189
chr14518059945181190E07325691
chr14518285545183659E07327947
chr14510594045106133E074-48775
chr14510751745107568E074-47340
chr14510807145108156E074-46752
chr14510855445108685E074-46223
chr14510871045108847E074-46061
chr14510929645109349E074-45559
chr14510958545109639E074-45269
chr14510972645109894E074-45014
chr14511062545110726E074-44182
chr14511083445110899E074-44009
chr14511113045111775E074-43133
chr14511185045111956E074-42952
chr14511348845113634E074-41274
chr14511371745113913E074-40995
chr14511424645114763E074-40145
chr14511485345114931E074-39977
chr14511499345115043E074-39865
chr14511584745116470E074-38438
chr14511902445119149E074-35759
chr14512132845121503E074-33405
chr14513683845136901E074-18007
chr14513777845138440E074-16468
chr14513847845138719E074-16189
chr14514276945143222E074-11686
chr14517368145173911E07418773
chr14514122345141277E081-13631
chr14518205145182147E08127143
chr14518235545182453E08127447
chr14518285545183659E08127947
chr14518392145184032E08129013
chr14518458045184694E08129672
chr14518479045184859E08129882
chr14518512545185237E08130217
chr14518524645185381E08130338
chr14513777845138440E082-16468
chr14513847845138719E082-16189
chr14518285545183659E08227947
chr14518392145184032E08229013
chr14518458045184694E08229672
chr14518479045184859E08229882
chr14518512545185237E08230217
chr14518524645185381E08230338










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr14513873045140922E067-13986
chr14513873045140922E068-13986
chr14513873045140922E069-13986
chr14513873045140922E070-13986
chr14513873045140922E071-13986
chr14513873045140922E072-13986
chr14513873045140922E073-13986
chr14513873045140922E074-13986
chr14513873045140922E081-13986
chr14513873045140922E082-13986