rs7574501

Homo sapiens
A>G
DNER : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0263 (7890/29928,GnomAD)
G=0261 (7620/29118,TOPMED)
G=0309 (1547/5008,1000G)
G=0217 (837/3854,ALSPAC)
G=0216 (802/3708,TWINSUK)
chr2:229681362 (GRCh38.p7) (2q36.3)
AD
GWASdb2
1   publication(s)
See rs on genome
142 Enhancers around
25 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.229681362A>G
GRCh37.p13 chr 2NC_000002.11:g.230546078A>G

Gene: DNER, delta/notch like EGF repeat containing(minus strand)

Molecule type Change Amino acid[Codon] SO Term
DNER transcriptNM_139072.3:c.N/AIntron Variant
DNER transcript variant X1XM_005246950.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.634G=0.366
1000GenomesAmericanSub694A=0.770G=0.230
1000GenomesEast AsianSub1008A=0.635G=0.365
1000GenomesEuropeSub1006A=0.772G=0.228
1000GenomesGlobalStudy-wide5008A=0.691G=0.309
1000GenomesSouth AsianSub978A=0.690G=0.310
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.783G=0.217
The Genome Aggregation DatabaseAfricanSub8702A=0.686G=0.314
The Genome Aggregation DatabaseAmericanSub838A=0.790G=0.210
The Genome Aggregation DatabaseEast AsianSub1610A=0.648G=0.352
The Genome Aggregation DatabaseEuropeSub18476A=0.765G=0.234
The Genome Aggregation DatabaseGlobalStudy-wide29928A=0.736G=0.263
The Genome Aggregation DatabaseOtherSub302A=0.750G=0.250
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.738G=0.261
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.784G=0.216
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs75745010.00095alcohol dependence20201924

eQTL of rs7574501 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7574501 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2230499439230499538E067-46540
chr2230499540230499846E067-46232
chr2230501390230501533E067-44545
chr2230517481230517792E067-28286
chr2230517823230518013E067-28065
chr2230518085230518153E067-27925
chr2230518223230518657E067-27421
chr2230522978230523388E067-22690
chr2230534695230534783E067-11295
chr2230540254230540570E067-5508
chr2230540602230540662E067-5416
chr2230560748230560924E06714670
chr2230561012230561097E06714934
chr2230566535230566696E06720457
chr2230568984230569293E06722906
chr2230570036230570086E06723958
chr2230572649230572721E06726571
chr2230573192230573513E06727114
chr2230577001230577098E06730923
chr2230499439230499538E068-46540
chr2230499540230499846E068-46232
chr2230510904230511322E068-34756
chr2230517481230517792E068-28286
chr2230517823230518013E068-28065
chr2230518085230518153E068-27925
chr2230518223230518657E068-27421
chr2230522978230523388E068-22690
chr2230534695230534783E068-11295
chr2230540254230540570E068-5508
chr2230540602230540662E068-5416
chr2230551344230551505E0685266
chr2230554150230554344E0688072
chr2230560748230560924E06814670
chr2230568984230569293E06822906
chr2230570036230570086E06823958
chr2230572649230572721E06826571
chr2230573192230573513E06827114
chr2230580595230580919E06834517
chr2230499439230499538E069-46540
chr2230499540230499846E069-46232
chr2230510904230511322E069-34756
chr2230517481230517792E069-28286
chr2230517823230518013E069-28065
chr2230518085230518153E069-27925
chr2230518223230518657E069-27421
chr2230522978230523388E069-22690
chr2230534695230534783E069-11295
chr2230540602230540662E069-5416
chr2230549815230549873E0693737
chr2230550082230550137E0694004
chr2230566535230566696E06920457
chr2230570036230570086E06923958
chr2230573192230573513E06927114
chr2230580595230580919E06934517
chr2230498403230498589E070-47489
chr2230517823230518013E070-28065
chr2230518085230518153E070-27925
chr2230518223230518657E070-27421
chr2230522978230523388E070-22690
chr2230549815230549873E0703737
chr2230550082230550137E0704004
chr2230551344230551505E0705266
chr2230498403230498589E071-47489
chr2230499439230499538E071-46540
chr2230499540230499846E071-46232
chr2230510904230511322E071-34756
chr2230517481230517792E071-28286
chr2230517823230518013E071-28065
chr2230518085230518153E071-27925
chr2230518223230518657E071-27421
chr2230522978230523388E071-22690
chr2230534695230534783E071-11295
chr2230540254230540570E071-5508
chr2230540602230540662E071-5416
chr2230550082230550137E0714004
chr2230551344230551505E0715266
chr2230554150230554344E0718072
chr2230562962230563044E07116884
chr2230566535230566696E07120457
chr2230568313230568368E07122235
chr2230570036230570086E07123958
chr2230573192230573513E07127114
chr2230498403230498589E072-47489
chr2230517481230517792E072-28286
chr2230517823230518013E072-28065
chr2230518085230518153E072-27925
chr2230518223230518657E072-27421
chr2230522978230523388E072-22690
chr2230534695230534783E072-11295
chr2230540254230540570E072-5508
chr2230540602230540662E072-5416
chr2230566535230566696E07220457
chr2230572649230572721E07226571
chr2230573192230573513E07227114
chr2230577001230577098E07230923
chr2230498403230498589E073-47489
chr2230499439230499538E073-46540
chr2230499540230499846E073-46232
chr2230517481230517792E073-28286
chr2230517823230518013E073-28065
chr2230540602230540662E073-5416
chr2230572649230572721E07326571
chr2230580595230580919E07334517
chr2230498403230498589E074-47489
chr2230499439230499538E074-46540
chr2230499540230499846E074-46232
chr2230510904230511322E074-34756
chr2230517481230517792E074-28286
chr2230517823230518013E074-28065
chr2230518085230518153E074-27925
chr2230518223230518657E074-27421
chr2230522978230523388E074-22690
chr2230534695230534783E074-11295
chr2230540254230540570E074-5508
chr2230540602230540662E074-5416
chr2230551344230551505E0745266
chr2230554150230554344E0748072
chr2230562792230562897E07416714
chr2230562962230563044E07416884
chr2230566535230566696E07420457
chr2230568984230569293E07422906
chr2230570036230570086E07423958
chr2230572649230572721E07426571
chr2230573192230573513E07427114
chr2230498403230498589E081-47489
chr2230499439230499538E081-46540
chr2230499540230499846E081-46232
chr2230517481230517792E081-28286
chr2230517823230518013E081-28065
chr2230518085230518153E081-27925
chr2230522978230523388E081-22690
chr2230551344230551505E0815266
chr2230510904230511322E082-34756
chr2230517481230517792E082-28286
chr2230517823230518013E082-28065
chr2230518085230518153E082-27925
chr2230518223230518657E082-27421
chr2230522978230523388E082-22690
chr2230549815230549873E0823737
chr2230550082230550137E0824004
chr2230562962230563044E08216884
chr2230580595230580919E08234517










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr2230577606230577676E06731528
chr2230577892230578021E06731814
chr2230578154230580284E06732076
chr2230577606230577676E06831528
chr2230577892230578021E06831814
chr2230578154230580284E06832076
chr2230577892230578021E06931814
chr2230578154230580284E06932076
chr2230577606230577676E07031528
chr2230577892230578021E07031814
chr2230578154230580284E07032076
chr2230577606230577676E07131528
chr2230577892230578021E07131814
chr2230578154230580284E07132076
chr2230577606230577676E07231528
chr2230577892230578021E07231814
chr2230578154230580284E07232076
chr2230577892230578021E07331814
chr2230578154230580284E07332076
chr2230577892230578021E07431814
chr2230578154230580284E07432076
chr2230577892230578021E08131814
chr2230577606230577676E08231528
chr2230577892230578021E08231814
chr2230578154230580284E08232076