rs758411

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0121 (3646/29952,GnomAD)
A==0111 (3232/29118,TOPMED)
A==0169 (846/5008,1000G)
A==0139 (536/3854,ALSPAC)
A==0130 (482/3708,TWINSUK)
chr17:34549927 (GRCh38.p7) (17q12)
AD
GWASdb2
1   publication(s)
See rs on genome
97 Enhancers around
35 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.34549927A>G
GRCh37.p13 chr 17NC_000017.10:g.32876946A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.083G=0.917
1000GenomesAmericanSub694A=0.100G=0.900
1000GenomesEast AsianSub1008A=0.258G=0.742
1000GenomesEuropeSub1006A=0.135G=0.865
1000GenomesGlobalStudy-wide5008A=0.169G=0.831
1000GenomesSouth AsianSub978A=0.280G=0.720
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.139G=0.861
The Genome Aggregation DatabaseAfricanSub8724A=0.075G=0.925
The Genome Aggregation DatabaseAmericanSub838A=0.100G=0.900
The Genome Aggregation DatabaseEast AsianSub1616A=0.259G=0.741
The Genome Aggregation DatabaseEuropeSub18472A=0.131G=0.868
The Genome Aggregation DatabaseGlobalStudy-wide29952A=0.121G=0.878
The Genome Aggregation DatabaseOtherSub302A=0.180G=0.820
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.111G=0.889
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.130G=0.870
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs7584110.000242alcohol dependence24277619

eQTL of rs758411 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs758411 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr173292524632925408E06748300
chr173292541932925473E06748473
chr173292548632925692E06748540
chr173292577632925914E06748830
chr173292601932926102E06749073
chr173292613832926202E06749192
chr173283055832830608E068-46338
chr173285982332859923E068-17023
chr173286011632860175E068-16771
chr173291488132914931E06837935
chr173291511932915235E06838173
chr173292524632925408E06848300
chr173292541932925473E06848473
chr173292548632925692E06848540
chr173292577632925914E06848830
chr173292601932926102E06849073
chr173292613832926202E06849192
chr173292524632925408E06948300
chr173292541932925473E06948473
chr173292548632925692E06948540
chr173287705032877304E070104
chr173288036232880423E0703416
chr173288051932880559E0703573
chr173288068932880774E0703743
chr173288080832880990E0703862
chr173288101532881203E0704069
chr173288123332881328E0704287
chr173288204232882138E0705096
chr173288288632883017E0705940
chr173288313432883184E0706188
chr173288404732884239E0707101
chr173289831532898365E07021369
chr173289853232898582E07021586
chr173289858632898636E07021640
chr173289879432899069E07021848
chr173290481632904895E07027870
chr173292391632924241E07046970
chr173292524632925408E07048300
chr173292541932925473E07048473
chr173292548632925692E07048540
chr173292577632925914E07048830
chr173292601932926102E07049073
chr173292613832926202E07049192
chr173289831532898365E07121369
chr173291241932912469E07135473
chr173291888832918960E07141942
chr173292524632925408E07148300
chr173292541932925473E07148473
chr173292548632925692E07148540
chr173292577632925914E07148830
chr173292601932926102E07149073
chr173292613832926202E07149192
chr173289449932894587E07217553
chr173289546132895528E07218515
chr173291205332912306E07235107
chr173291241932912469E07235473
chr173291549332915543E07238547
chr173291556132915641E07238615
chr173292524632925408E07248300
chr173292541932925473E07248473
chr173292548632925692E07248540
chr173292577632925914E07248830
chr173292601932926102E07249073
chr173292613832926202E07249192
chr173289449932894587E07317553
chr173289466232894712E07317716
chr173289479532895046E07317849
chr173289559732895669E07318651
chr173289568132895799E07318735
chr173290446432904670E07327518
chr173290481632904895E07327870
chr173291205332912306E07335107
chr173291241932912469E07335473
chr173291488132914931E07337935
chr173292524632925408E07348300
chr173292541932925473E07348473
chr173292548632925692E07348540
chr173292577632925914E07348830
chr173292601932926102E07349073
chr173292613832926202E07349192
chr173289831532898365E07421369
chr173289853232898582E07421586
chr173289858632898636E07421640
chr173291549332915543E07438547
chr173292524632925408E07448300
chr173292541932925473E07448473
chr173292548632925692E07448540
chr173292577632925914E07448830
chr173292601932926102E07449073
chr173292613832926202E07449192
chr173288385232883989E0816906
chr173288404732884239E0817101
chr173289546132895528E08118515
chr173288385232883989E0826906
chr173288404732884239E0827101
chr173289853232898582E08221586
chr173289858632898636E08221640










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr173290520832906994E06728262
chr173290704232908479E06730096
chr173290852432908636E06731578
chr173290865732908874E06731711
chr173290893032909140E06731984
chr173290520832906994E06828262
chr173290704232908479E06830096
chr173290852432908636E06831578
chr173290865732908874E06831711
chr173290893032909140E06831984
chr173290520832906994E06928262
chr173290852432908636E06931578
chr173290865732908874E06931711
chr173290893032909140E06931984
chr173290520832906994E07028262
chr173290520832906994E07128262
chr173290852432908636E07131578
chr173290865732908874E07131711
chr173290893032909140E07131984
chr173290520832906994E07228262
chr173290704232908479E07230096
chr173290852432908636E07231578
chr173290865732908874E07231711
chr173290893032909140E07231984
chr173290520832906994E07328262
chr173290704232908479E07330096
chr173290852432908636E07331578
chr173290865732908874E07331711
chr173290893032909140E07331984
chr173290520832906994E07428262
chr173290704232908479E07430096
chr173290852432908636E07431578
chr173290865732908874E07431711
chr173290520832906994E08228262
chr173290852432908636E08231578