rs7591784

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0473 (14043/29686,GnomAD)
G=0486 (14171/29118,TOPMED)
A==0500 (2503/5008,1000G)
G=0451 (1738/3854,ALSPAC)
G=0447 (1658/3708,TWINSUK)
chr2:207637006 (GRCh38.p7) (2q33.3)
OD
GWASdb2
2   publication(s)
See rs on genome
21 Enhancers around
27 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.207637006A>G
GRCh37.p13 chr 2NC_000002.11:g.208501730A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.488G=0.512
1000GenomesAmericanSub694A=0.540G=0.460
1000GenomesEast AsianSub1008A=0.406G=0.594
1000GenomesEuropeSub1006A=0.529G=0.471
1000GenomesGlobalStudy-wide5008A=0.500G=0.500
1000GenomesSouth AsianSub978A=0.560G=0.440
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.549G=0.451
The Genome Aggregation DatabaseAfricanSub8634A=0.482G=0.518
The Genome Aggregation DatabaseAmericanSub830A=0.560G=0.440
The Genome Aggregation DatabaseEast AsianSub1572A=0.416G=0.584
The Genome Aggregation DatabaseEuropeSub18348A=0.556G=0.443
The Genome Aggregation DatabaseGlobalStudy-wide29686A=0.526G=0.473
The Genome Aggregation DatabaseOtherSub302A=0.490G=0.510
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.513G=0.486
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.553G=0.447
PMID Title Author Journal
23183491Genome-wide association study identifies a potent locus associated with human opioid sensitivity.Nishizawa DMol Psychiatry
26736037Single nucleotide polymorphism near CREB1, rs7591784, is associated with pretreatment methamphetamine use frequency and outcome of outpatient treatment for methamphetamine use disorder.Heinzerling KGJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs75917841.06E-06Opioid sensitivity23183491

eQTL of rs7591784 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7591784 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2208467556208467656E067-34074
chr2208467955208468204E067-33526
chr2208468345208468451E067-33279
chr2208467955208468204E068-33526
chr2208468345208468451E068-33279
chr2208467556208467656E069-34074
chr2208467955208468204E069-33526
chr2208468345208468451E069-33279
chr2208528918208529061E07027188
chr2208530054208530175E07028324
chr2208530194208530330E07028464
chr2208468345208468451E071-33279
chr2208477393208477872E071-23858
chr2208467556208467656E072-34074
chr2208467955208468204E072-33526
chr2208468345208468451E072-33279
chr2208477393208477872E072-23858
chr2208482460208482572E072-19158
chr2208486395208486519E073-15211
chr2208487298208487338E073-14392
chr2208491753208492513E073-9217







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr2208488612208488838E067-12892
chr2208488906208491332E067-10398
chr2208488612208488838E068-12892
chr2208488906208491332E068-10398
chr2208491433208491516E068-10214
chr2208491536208491597E068-10133
chr2208491630208491681E068-10049
chr2208488612208488838E069-12892
chr2208488906208491332E069-10398
chr2208488612208488838E070-12892
chr2208488906208491332E070-10398
chr2208488612208488838E071-12892
chr2208488906208491332E071-10398
chr2208491433208491516E071-10214
chr2208491536208491597E071-10133
chr2208491630208491681E071-10049
chr2208488612208488838E072-12892
chr2208488906208491332E072-10398
chr2208488612208488838E073-12892
chr2208488906208491332E073-10398
chr2208488612208488838E074-12892
chr2208488906208491332E074-10398
chr2208488906208491332E081-10398
chr2208488612208488838E082-12892
chr2208488906208491332E082-10398
chr2208491433208491516E082-10214
chr2208491536208491597E082-10133