rs7615893

Homo sapiens
T>C
FLNB : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0389 (11676/29954,GnomAD)
C=0428 (12466/29118,TOPMED)
T==0392 (1963/5008,1000G)
C=0255 (982/3854,ALSPAC)
C=0237 (879/3708,TWINSUK)
chr3:58112717 (GRCh38.p7) (3p14.3)
AD
GWASdb2
1   publication(s)
See rs on genome
165 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.58112717T>C
GRCh37.p13 chr 3NC_000003.11:g.58098444T>C
FLNB RefSeqGeneNG_012801.1:g.109318T>C

Gene: FLNB, filamin B(plus strand)

Molecule type Change Amino acid[Codon] SO Term
FLNB transcript variant 1NM_001164317.1:c.N/AIntron Variant
FLNB transcript variant 3NM_001164318.1:c.N/AIntron Variant
FLNB transcript variant 4NM_001164319.1:c.N/AIntron Variant
FLNB transcript variant 2NM_001457.3:c.N/AIntron Variant
FLNB transcript variant X1XM_005264978.1:c.N/AIntron Variant
FLNB transcript variant X2XR_001740065.1:n.N/AIntron Variant
FLNB transcript variant X3XR_940396.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.370C=0.630
1000GenomesAmericanSub694T=0.510C=0.490
1000GenomesEast AsianSub1008T=0.027C=0.973
1000GenomesEuropeSub1006T=0.711C=0.289
1000GenomesGlobalStudy-wide5008T=0.392C=0.608
1000GenomesSouth AsianSub978T=0.390C=0.610
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.745C=0.255
The Genome Aggregation DatabaseAfricanSub8710T=0.434C=0.566
The Genome Aggregation DatabaseAmericanSub838T=0.470C=0.530
The Genome Aggregation DatabaseEast AsianSub1620T=0.028C=0.972
The Genome Aggregation DatabaseEuropeSub18484T=0.747C=0.252
The Genome Aggregation DatabaseGlobalStudy-wide29954T=0.610C=0.389
The Genome Aggregation DatabaseOtherSub302T=0.800C=0.200
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.571C=0.428
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.763C=0.237
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs76158930.000697alcohol dependence21314694

eQTL of rs7615893 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs7615893 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr35805154058051796E067-46648
chr35805385558054143E067-44301
chr35805419758054344E067-44100
chr35806774858068130E067-30314
chr35814042258140740E06741978
chr35814074558141049E06742301
chr35814540958145571E06746965
chr35814559558145728E06747151
chr35805385558054143E068-44301
chr35805419758054344E068-44100
chr35805899558059039E068-39405
chr35805908058059415E068-39029
chr35808055858080630E068-17814
chr35808815658088480E068-9964
chr35808860558089245E068-9199
chr35808929658089485E068-8959
chr35810269958102760E0684255
chr35810281358102887E0684369
chr35810288858103220E0684444
chr35810327258103870E0684828
chr35810589458106100E0687450
chr35810611258106581E0687668
chr35813728858137347E06838844
chr35813747958137617E06839035
chr35814042258140740E06841978
chr35814074558141049E06842301
chr35804861858048803E069-49641
chr35804884658048930E069-49514
chr35804896358049531E069-48913
chr35805034558050455E069-47989
chr35805385558054143E069-44301
chr35805419758054344E069-44100
chr35805549358055543E069-42901
chr35810611258106581E0697668
chr35810664458106924E0698200
chr35813728858137347E06938844
chr35813747958137617E06939035
chr35814042258140740E06941978
chr35814074558141049E06942301
chr35814540958145571E06946965
chr35814559558145728E06947151
chr35805419758054344E070-44100
chr35810327258103870E0704828
chr35813728858137347E07038844
chr35813747958137617E07039035
chr35814042258140740E07041978
chr35814074558141049E07042301
chr35804861858048803E071-49641
chr35804884658048930E071-49514
chr35804896358049531E071-48913
chr35805255858052938E071-45506
chr35805301458053238E071-45206
chr35805385558054143E071-44301
chr35805419758054344E071-44100
chr35805549358055543E071-42901
chr35805565058055760E071-42684
chr35805730458057833E071-40611
chr35805789858058194E071-40250
chr35805824058058343E071-40101
chr35805845958058509E071-39935
chr35805852358058789E071-39655
chr35805899558059039E071-39405
chr35805908058059415E071-39029
chr35805954558059749E071-38695
chr35808990858090083E071-8361
chr35810281358102887E0714369
chr35810288858103220E0714444
chr35810327258103870E0714828
chr35810409158104157E0715647
chr35813667758136784E07138233
chr35813728858137347E07138844
chr35813747958137617E07139035
chr35814042258140740E07141978
chr35814074558141049E07142301
chr35804861858048803E072-49641
chr35804884658048930E072-49514
chr35804896358049531E072-48913
chr35805255858052938E072-45506
chr35805301458053238E072-45206
chr35805385558054143E072-44301
chr35805419758054344E072-44100
chr35805549358055543E072-42901
chr35805565058055760E072-42684
chr35805845958058509E072-39935
chr35805852358058789E072-39655
chr35805899558059039E072-39405
chr35805908058059415E072-39029
chr35805954558059749E072-38695
chr35810555958105701E0727115
chr35810589458106100E0727450
chr35813747958137617E07239035
chr35814042258140740E07241978
chr35814074558141049E07242301
chr35805385558054143E073-44301
chr35805419758054344E073-44100
chr35805789858058194E073-40250
chr35805824058058343E073-40101
chr35806774858068130E073-30314
chr35813728858137347E07338844
chr35813747958137617E07339035
chr35814540958145571E07346965
chr35814559558145728E07347151
chr35804861858048803E074-49641
chr35804884658048930E074-49514
chr35804896358049531E074-48913
chr35805105858051143E074-47301
chr35805118358051271E074-47173
chr35805154058051796E074-46648
chr35805255858052938E074-45506
chr35805301458053238E074-45206
chr35805385558054143E074-44301
chr35805419758054344E074-44100
chr35805549358055543E074-42901
chr35805565058055760E074-42684
chr35810281358102887E0744369
chr35810288858103220E0744444
chr35810327258103870E0744828
chr35810555958105701E0747115
chr35810589458106100E0747450
chr35813667758136784E07438233
chr35813728858137347E07438844
chr35813747958137617E07439035
chr35814042258140740E07441978
chr35814074558141049E07442301
chr35814540958145571E07446965
chr35814559558145728E07447151
chr35805789858058194E081-40250
chr35805824058058343E081-40101
chr35805845958058509E081-39935
chr35805852358058789E081-39655
chr35805899558059039E081-39405
chr35805908058059415E081-39029
chr35805954558059749E081-38695
chr35806000158060507E081-37937
chr35806083158060958E081-37486
chr35806122958061284E081-37160
chr35810174858102687E0813304
chr35810269958102760E0814255
chr35810281358102887E0814369
chr35810288858103220E0814444
chr35810327258103870E0814828
chr35810409158104157E0815647
chr35810462958105408E0816185
chr35810555958105701E0817115
chr35810589458106100E0817450
chr35810611258106581E0817668
chr35810664458106924E0818200
chr35813047158130766E08132027
chr35813082458130924E08132380
chr35813728858137347E08138844
chr35813747958137617E08139035
chr35805385558054143E082-44301
chr35805419758054344E082-44100
chr35805908058059415E082-39029
chr35805954558059749E082-38695
chr35810269958102760E0824255
chr35810281358102887E0824369
chr35810288858103220E0824444
chr35810327258103870E0824828
chr35810409158104157E0825647
chr35810462958105408E0826185
chr35810589458106100E0827450
chr35810611258106581E0827668
chr35813728858137347E08238844
chr35813747958137617E08239035