rs763090

Homo sapiens
T>C
TPST2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0413 (12373/29894,GnomAD)
T==0422 (12293/29116,TOPMED)
T==0317 (1587/5008,1000G)
T==0429 (1655/3854,ALSPAC)
T==0431 (1598/3708,TWINSUK)
chr22:26574051 (GRCh38.p7) (22q12.1)
ND
GWASdb2
1   publication(s)
See rs on genome
133 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 22NC_000022.11:g.26574051T>C
GRCh37.p13 chr 22NC_000022.10:g.26970016T>C

Gene: TPST2, tyrosylprotein sulfotransferase 2(minus strand)

Molecule type Change Amino acid[Codon] SO Term
TPST2 transcript variant 2NM_003595.3:c.N/AIntron Variant
TPST2 transcript variant 1NM_001008566.1:c.N/AGenic Upstream Transcript Variant
TPST2 transcript variant X1XM_006724338.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.428C=0.572
1000GenomesAmericanSub694T=0.270C=0.730
1000GenomesEast AsianSub1008T=0.228C=0.772
1000GenomesEuropeSub1006T=0.417C=0.583
1000GenomesGlobalStudy-wide5008T=0.317C=0.683
1000GenomesSouth AsianSub978T=0.190C=0.810
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.429C=0.571
The Genome Aggregation DatabaseAfricanSub8700T=0.435C=0.565
The Genome Aggregation DatabaseAmericanSub838T=0.290C=0.710
The Genome Aggregation DatabaseEast AsianSub1612T=0.208C=0.792
The Genome Aggregation DatabaseEuropeSub18444T=0.428C=0.571
The Genome Aggregation DatabaseGlobalStudy-wide29894T=0.413C=0.586
The Genome Aggregation DatabaseOtherSub300T=0.360C=0.640
Trans-Omics for Precision MedicineGlobalStudy-wide29116T=0.422C=0.577
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.431C=0.569
PMID Title Author Journal
19268276Genome-wide association study of smoking initiation and current smoking.Vink JMAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs7630907.75E-05nicotine smoking19268276

eQTL of rs763090 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs763090 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr222694240826942627E067-27389
chr222694264626942706E067-27310
chr222694293626942990E067-27026
chr222694307626943169E067-26847
chr222695279126953283E067-16733
chr222695350926953626E067-16390
chr222695463426954910E067-15106
chr222695500526955081E067-14935
chr222695785426957995E067-12021
chr222695800826958648E067-11368
chr222696390626964849E067-5167
chr222696612026966404E067-3612
chr222696643126966683E067-3333
chr222696674326966900E067-3116
chr222698088226981692E06710866
chr222698249426983060E06712478
chr222698307426983146E06713058
chr222698315926983373E06713143
chr222700619327006794E06736177
chr222700682027006879E06736804
chr222694189726942024E068-27992
chr222694216826942273E068-27743
chr222694240826942627E068-27389
chr222694264626942706E068-27310
chr222694293626942990E068-27026
chr222694614326947058E068-22958
chr222694721926947588E068-22428
chr222695007826950180E068-19836
chr222695018626950428E068-19588
chr222695047126950599E068-19417
chr222695071626950766E068-19250
chr222695088826951342E068-18674
chr222695785426957995E068-12021
chr222696390626964849E068-5167
chr222696643126966683E068-3333
chr222696674326966900E068-3116
chr222700682027006879E06836804
chr222700696827007447E06836952
chr222701522227015323E06845206
chr222694240826942627E069-27389
chr222694264626942706E069-27310
chr222694614326947058E069-22958
chr222694809226948153E069-21863
chr222695088826951342E069-18674
chr222695147526951713E069-18303
chr222695177426951953E069-18063
chr222695279126953283E069-16733
chr222696643126966683E069-3333
chr222696674326966900E069-3116
chr222697002926970079E06913
chr222697036826970750E069352
chr222698088226981692E06910866
chr222700619327006794E06936177
chr222700682027006879E06936804
chr222700696827007447E06936952
chr222695088826951342E070-18674
chr222695147526951713E070-18303
chr222695177426951953E070-18063
chr222692363626924410E071-45606
chr222695422926954410E071-15606
chr222695447826954591E071-15425
chr222695463426954910E071-15106
chr222695785426957995E071-12021
chr222695800826958648E071-11368
chr222696390626964849E071-5167
chr222696521126965361E071-4655
chr222698088226981692E07110866
chr222700619327006794E07136177
chr222700682027006879E07136804
chr222700696827007447E07136952
chr222701230827012418E07142292
chr222701245927012499E07142443
chr222694216826942273E072-27743
chr222694240826942627E072-27389
chr222694264626942706E072-27310
chr222694293626942990E072-27026
chr222695147526951713E072-18303
chr222695177426951953E072-18063
chr222695279126953283E072-16733
chr222695422926954410E072-15606
chr222695447826954591E072-15425
chr222695463426954910E072-15106
chr222695800826958648E072-11368
chr222696390626964849E072-5167
chr222696612026966404E072-3612
chr222696643126966683E072-3333
chr222696674326966900E072-3116
chr222696700226967074E072-2942
chr222696714426967329E072-2687
chr222698088226981692E07210866
chr222698795326988852E07217937
chr222698885426988950E07218838
chr222700682027006879E07236804
chr222692336226923520E073-46496
chr222692363626924410E073-45606
chr222694264626942706E073-27310
chr222694614326947058E073-22958
chr222695147526951713E073-18303
chr222695177426951953E073-18063
chr222695279126953283E073-16733
chr222695422926954410E073-15606
chr222695447826954591E073-15425
chr222695463426954910E073-15106
chr222695599726956352E073-13664
chr222695785426957995E073-12021
chr222695800826958648E073-11368
chr222695891526958968E073-11048
chr222695898826959304E073-10712
chr222696348526963535E073-6481
chr222696390626964849E073-5167
chr222696612026966404E073-3612
chr222696643126966683E073-3333
chr222696674326966900E073-3116
chr222696862426968674E073-1342
chr222696867826968728E073-1288
chr222698088226981692E07310866
chr222698307426983146E07313058
chr222700619327006794E07336177
chr222700682027006879E07336804
chr222700696827007447E07336952
chr222695007826950180E074-19836
chr222695018626950428E074-19588
chr222695047126950599E074-19417
chr222695071626950766E074-19250
chr222695088826951342E074-18674
chr222695147526951713E074-18303
chr222695177426951953E074-18063
chr222700682027006879E07436804
chr222692336226923520E081-46496
chr222692363626924410E081-45606
chr222696612026966404E081-3612
chr222696643126966683E081-3333
chr222696674326966900E081-3116









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr222698455426986979E06714538
chr222698455426986979E06814538
chr222698455426986979E06914538
chr222698455426986979E07014538
chr222698455426986979E07114538
chr222698455426986979E07214538
chr222698455426986979E07314538
chr222698455426986979E07414538
chr222698455426986979E08114538
chr222698455426986979E08214538